Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Karin S. Bentley"'
1
An in vitro approach for comparative interspecies metabolism of agrochemicals
Autor: Paul Whalley, Matthew W. Himmelstein, Fagen Zhang, Karin S. Bentley, Jyotigna Mehta, Birgit Neumann, Marco Corvaro, Michael J. Bartels, Dorothee Funk, Christian Strupp
Publikováno v: Regulatory Toxicology and Pharmacology. 88:322-327
The metabolism and elimination of a xenobiotic has a direct bearing on its potential to cause toxicity in an organism. The confidence with which data from safety studies can be extrapolated to humans depends, among other factors, upon knowing whether
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7663b51a2a9ac5ccad785258cc25d2
https://doi.org/10.1016/j.yrtph.2017.03.020
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2
Relevance of the 1-year dog study in assessing human health risks for registration of pesticides. An update to include pesticides registered in Japan
Autor: Ivana Fegert, Werner Kobel, Masako Sato, Karin S. Bentley, Carole Langrand-Lerche, Bennard van Ravenzwaay, Eric Debruyne, Christian Strupp, Phil Botham, Richard Billington, Richard Lewis
Publikováno v: Critical Reviews in Toxicology. 44:842-848
Over 400 active pesticides are registered in Japan (FAMIC 2013). The results of dog toxicity studies (usually, the 1-year study) were used by the Japanese regulatory authorities to establish the acceptable daily intake (ADI) for 45 pesticide active i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb5a2469fe62b8d413e456a1765d59d
https://doi.org/10.3109/10408444.2014.936550
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3
Relevance Weighting of Tier 1 Endocrine Screening Endpoints by Rank Order
Autor: Barbara H. Neal, Frederick G. Hess, Sandeep Mukhi, David R. Geter, Leah D. Stuchal, Christopher J. Borgert, Catherine M. Holmes, Lisa S. Ortego, John M. Brausch, Ellen Mihaich, Suzanne I. Snajdr, Abraham Tobia, Sue Marty, Karin S. Bentley, Jane P. Staveley, Katie Coady, David Saltmiras, Steve L. Levine, Patrick D. Guiney, Matthew J. LeBaron, Elliot B. Gordon, Richard A. Becker
Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:90-113
Weight of evidence (WoE) approaches are recommended for interpreting various toxicological data, but few systematic and transparent procedures exist. A hypothesis-based WoE framework was recently published focusing on the U.S. EPA's Tier 1 Endocrine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ae6a956a658ad7ac7c5b8da45190d2
https://doi.org/10.1002/bdrb.21096
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5
Hypothesis-driven weight of evidence framework for evaluating data within the US EPA’s Endocrine Disruptor Screening Program
Autor: Ellen Mihaich, Christopher J. Borgert, Karin S. Bentley, Richard A. Becker, Lisa S. Ortego, Catherine M. Holmes, Steven L. Levine
Publikováno v: Regulatory Toxicology and Pharmacology. 61(2):185-191
“Weight of Evidence” (WoE) approaches are often used to critically examine, prioritize, and integrate results from different types of studies to reach general conclusions. For assessing hormonally active agents, WoE evaluations are necessary to a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6514befd2a8ace40c29a8c383fbbdc
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6
A 1-year toxicity study in dogs is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides
Autor: Ivana Fegert, Phil Botham, Werner Bomann, Bernhard Stahl, Bennard van Ravenzwaay, Horst Spielmann, Werner Kobel, Karin S. Bentley, Richard Lewis, Richard Billington
Publikováno v: Critical Reviews in Toxicology. 40:1-15
A review of publications on pesticides assessing the need for 1-year toxicity studies in dogs was performed. Four key peer-reviewed papers with different approaches investigated the value of a 1-year dog study in addition to a 3-month study. Despite
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34fd5d291aa31b7d7fc7778bfba6d9b
https://doi.org/10.3109/10408440903300098
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7
A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment
Autor: Sue M. Barlow, Larry P. Sheets, Susan L. Makris, Ronald N. Hines, David L. Eisenbrandt, Karen E. Whitby, Ralph L. Cooper, Lorraine F. H. Irvine, Carole A. Kimmel, Nancy G. Doerrer, James C. Lamb, Abby A. Li, Karin S. Bentley, Penelope A. Fenner-Crisp, Herman B. W. M. KOëTER, Gerrit J. A. Speijers, Angela M. Brady
Publikováno v: Critical Reviews in Toxicology. 36:69-98
A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b720b98595830081129ce521fe7d5f
https://doi.org/10.1080/10408440500541367
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8
EFFECT OF 4-VINYLCYCLOHEXENE ON MICRONUCLEUS FORMATION IN THE BONE MARROW OF RATS AND MICE
Autor: Christopher Bevan, Anthony S. Panepinto, Karin S. Bentley, Douglas A. Keller
Publikováno v: Drug and Chemical Toxicology. 24:273-285
This study was conducted to evaluate the potential of 4-vinylcyclohexene (VCH) to induce micronuclei in the bone marrow of mice and rats. Male and female Crl:CD BR (Sprague-Dawley) rats and B6C3F1/CrBR mice were exposed to VCH 6 hr/day for 2 days or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193dac5a0eabf5ec5f61bb80321ef336
https://doi.org/10.1081/dct-100103724
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9
Inhalation Toxicity and Genotoxicity of Hydrofluorocarbon (HFC)-236fa and HFC-236ea
Autor: David P. Kelly, Rudolph Valentine, Susan M. Munley, Kathy M. McGown, Karin S. Bentley, William J. Brock
Publikováno v: International Journal of Toxicology. 19:69-83
The acute, subchronic, and developmental and genetic toxicity of hydrofluorocarbon (HFC)-236fa and HFC-236ea were evaluated to assist in establishing proper handling guidance. In acute inhalation studies, rats were exposed whole body for 4 hours to v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c6a6de4f5452ee30a2c64f0d2dc01eb
https://doi.org/10.1080/109158100224881
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10
Chronic Toxicity, Oncogenicity, and Mutagenicity Studies with Chlorotetrafluoroethane (HCFC-124)
Autor: Glenn S. Elliott, George M. Rusch, Steven R. Frame, Linda A. Malley, Karin S. Bentley, Henry J. Trochimowicz, William J. Brock
Publikováno v: Drug and Chemical Toxicology. 21:417-447
The chronic toxicity, oncogenicity, and mutagenicity of chlorotetrafluoroethane (HCFC-124) were evaluated. In the chronic toxicity/oncogenicity study, male and female rats were exposed to 0, 2000, 10,000, or 50,000 ppm HCFC-124 for 6 hr/day, 5 days/w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e057f2e7c455835effbc1fc0841fff
https://doi.org/10.3109/01480549809002215
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