An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

Autor: Emilie Da Silva, Ulla Vogel, Karin S. Hougaard, Jesus Pérez-Gil, Yi Y. Zuo, Jorid B. Sørli

Publikováno v: Current Research in Toxicology, Vol 2, Iss , Pp 225-236 (2021)

Inhaled substances, such as consumer products, chemicals at the workplace, and nanoparticles, can affect the lung function in several ways. In this paper, we explore the adverse outcome pathway (AOP) that starts when inhaled substances that reach the

Externí odkaz: https://doaj.org/article/2adb973f5c6c40bb95c0328ddec734ff

Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice

Autor: Astrid Skovmand, Alexander C. Ø. Jensen, Clotilde Maurice, Francesco Marchetti, Anna J. Lauvås, Ismo K. Koponen, Keld A. Jensen, Sandra Goericke-Pesch, Ulla Vogel, Karin S. Hougaard

Publikováno v: Particle and Fibre Toxicology, Vol 16, Iss 1, Pp 1-13 (2019)

Abstract Background Previous findings indicate that in utero exposure to nanoparticles may affect the reproductive system in male offspring. Effects such as decreased sperm counts and testicular structural changes in F1 males have been reported follo

Externí odkaz: https://doaj.org/article/c472e5242b6742ee885e08fda245c009

Timing of puberty in relation to semen characteristics, testicular volume, and reproductive hormones:a cohort study

Autor: Nis Brix, Anne Gaml-Sorensen, Andreas Ernst, Linn Hakonsen Arendt, Lea Lykke Harrits Lunddorf, Gunnar Toft, Sandra S. Tottenborg, Katia Keglberg Haervig, Birgit Bjerre Hoyer, Karin S. Hougaard, Jens Peter E. Bonde, Cecilia Host Ramlau-Hansen

Publikováno v: Brix, N, Gaml-Sorensen, A, Ernst, A, Arendt, L H, Harrits Lunddorf, L L, Toft, G, Tottenborg, S S, Haervig, K K, Hoyer, B B, Hougaard, K S, Bonde, J P E & Ramlau-Hansen, C H 2023, ' Timing of puberty in relation to semen characteristics, testicular volume, and reproductive hormones : a cohort study ', Fertility and Sterility . https://doi.org/10.1016/j.fertnstert.2023.05.164

OBJECTIVE: To investigate if timing of puberty is associated with semen characteristics, testicular volume, and reproductive hormone levels.DESIGN: Cohort study.SUBJECTS: The Danish National Birth Cohort (DNBC) and its sub-cohort, the Fetal Programmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d430abd1e3e0cfb00829f8e77262bee9
https://pure.au.dk/portal/da/publications/timing-of-puberty-in-relation-to-semen-characteristics-testicular-volume-and-reproductive-hormones(fb166e51-f88a-42cc-8db0-eb86ef18082d).html

Night work during pregnancy and preterm birth-A large register-based cohort study.

Autor: Ina Olmer Specht, Paula E C Hammer, Esben M Flachs, Luise M Begtrup, Ann D Larsen, Karin S Hougaard, Johnni Hansen, Åse M Hansen, Henrik A Kolstad, Reiner Rugulies, Anne Helene Garde, Jens Peter Bonde

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0215748 (2019)

BackgroundMelatonin stimulates the production of progesterone, which is essential for the maintenance of pregnancy. Since melatonin in blood is reduced due to work under illuminated conditions during night work, it has been hypothesized that night wo

Externí odkaz: https://doaj.org/article/1a8c3958421b46f5a92a039a8d13b588

Genotoxicity in the absence of inflammation after tungsten inhalation in mice

Autor: Jorid B. Sørli, Alexander C.Ø. Jensen, Alicja Mortensen, Józef Szarek, Eleni Chatzigianelli, Claudia A.T. Gutierrez, Nicklas R. Jacobsen, Sarah S. Poulsen, Iosif Hafez, Charis Loizides, George Biskos, Karin S. Hougaard, Ulla Vogel, Niels Hadrup

Publikováno v: Sørli, J B, Jensen, A C Ø, Mortensen, A, Szarek, J, Chatzigianelli, E, Gutierrez, C A T, Jacobsen, N R, Poulsen, S S, Hafez, I, Loizides, C, Biskos, G, Hougaard, K S, Vogel, U & Hadrup, N 2023, ' Genotoxicity in the absence of inflammation after tungsten inhalation in mice ', Environmental Toxicology and Pharmacology, vol. 98, 104074 . https://doi.org/10.1016/j.etap.2023.104074
Environmental Toxicology and Pharmacology, 98

Tungsten is used in several applications and human exposure may occur. To assess its pulmonary toxicity, we exposed male mice to nose-only inhalation of tungsten particles at 9, 23 or 132 mg/m3 (Low, Mid and High exposure) (45 min/day, 5 days/week fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce4638791a09cbcfb0c968f3fac7c80
https://orbit.dtu.dk/en/publications/cd7577f8-5d5f-45eb-b605-2b559fd6b617