Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Karin Römisch"'
Autor:
Felipe H. Santiago-Tirado, Thomas Hurtaux, Jennifer Geddes-McAlister, Duy Nguyen, Volkhard Helms, Tamara L. Doering, Karin Römisch
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The fungal pathogen Cryptococcus neoformans is distinguished by a cell-wall-anchored polysaccharide capsule that is critical for virulence. Biogenesis of both cell wall and capsule relies on the secretory pathway. Protein secretion begins wi
Externí odkaz:
https://doaj.org/article/7a705d2e57474a73a7dffbac8608fa80
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008855 (2021)
The Sec complex catalyzes the translocation of proteins of the secretory pathway into the endoplasmic reticulum and the integration of membrane proteins into the endoplasmic reticulum membrane. Some substrate peptides require the presence and involve
Externí odkaz:
https://doaj.org/article/dbc6db1cf96144b5b94adbe37f88e0ce
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215950 (2019)
Sec61p is the channel-forming subunit of the heterotrimeric Sec61 complex that mediates co-translational protein import into the endoplasmic reticulum (ER). In yeast, proteins can also be post-translationally translocated by the hetero-heptameric Sec
Externí odkaz:
https://doaj.org/article/84fe562087ee42d59222bdca3d9ac63d
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211180 (2019)
Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transport conduit. Channel opening from the ER lumen must
Externí odkaz:
https://doaj.org/article/fc83a1b1a4cc4b308a444ee9c6a470ba
Autor:
Marie-Luise Kaiser, Karin Römisch
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117260 (2015)
Import of secretory proteins into the Endoplasmic Reticulum (ER) is an established function of the Sec61 channel. The contribution of the Sec61 channel to export of misfolded proteins from the ER for degradation by proteasomes is still controversial,
Externí odkaz:
https://doaj.org/article/ed7cfcad801b492ab499a85406f3a49f
Autor:
Christina Servas, Karin Römisch
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82058 (2013)
How misfolded proteins are exported from the ER to the cytosol for degradation (ER-associated Degradation, ERAD) and which proteins are participating in this process is not understood. Several studies using a single, leaky mutant indicated that Sec63
Externí odkaz:
https://doaj.org/article/e5241ed9947846919e346a6d1ddb9377
Autor:
Karin Römisch
Publikováno v:
F1000Research, Vol 1 (2012)
Malaria is caused by parasites which live in host erythrocytes and remodel these cells to provide optimally for the parasites’ needs by exporting effector proteins into the host cells. Eight years ago the discovery of a host cell targeting sequence
Externí odkaz:
https://doaj.org/article/42f60bd394e9498c99fe45222320f026
Publikováno v:
Alvira, S, Corey, R A, Collinson, I R & Römisch, K 2020, ' Membrane protein biogenesis by the EMC ', EMBO Journal, vol. 40, no. 2, e107407 . https://doi.org/10.15252/embj.2020107407
The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22dc8e0a44098eca555ae6a323d10ec
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1864(12)
Most eukaryotic secretory and membrane proteins are funneled by the Sec61 complex into the secretory pathway. Furthermore, some substrate peptides rely on two essential accessory proteins, Sec62 and Sec63, being present to assist with their transloca
Autor:
Felipe H. Santiago-Tirado, Thomas Hurtaux, Jennifer Geddes-McAlister, Duy Nguyen, Volkhard Helms, Tamara L. Doering, Karin Römisch
The fungal pathogenCryptococcus neoformansis distinguished by a cell wall-anchored polysaccharide capsule that is critical for virulence. Biogenesis of both cell wall and capsule relies on the secretory pathway. Protein secretion begins with polypept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c72ab229aaf33324979bf4dba8eb32e
https://doi.org/10.1101/2022.06.01.494298
https://doi.org/10.1101/2022.06.01.494298