Xath2, a bHLH gene expressed during a late transition stage of neurogenesis in the forebrain of Xenopus embryos

Autor: Eric Bellefroid, Kenneth Ryan, Vincent Taelman, Karin Opdecamp, Bernard Avalosse

Publikováno v: Mechanisms of Development. 101:199-202

We have identified a Xenopus bHLH gene, Xath2, which is the homologue of the murine MATH-2/NEX-1 gene, using a functional expression screening approach. Overexpression of this gene in neurula embryos induces the expression of the N-tubulin neuronal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fc6eab5291f5f39ad52f111c0d3650
https://doi.org/10.1016/s0925-4773(00)00546-3

Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently

Autor: Minh-Thanh T. Nguyen, Atsuo Nakayama, Karin Opdecamp, Catherine Chen, Colin A. Hodgkinson, Heinz Arnheiter

Publikováno v: Mechanisms of Development. 70(1-2):155-166

The mouse microphthalmia (Mitf) gene encodes a basic-helix-loop-helix-zipper transcription factor whose mutations are associated with abnormalities in neuroepithelial and neural crest-derived melanocytes. In wild type embryos, Mitf expression in neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902b778260efd8a5e44f397dae9f7496

Methylation of an α-foetoprotein gene intragenic site modulates gene activity

Autor: Montse Molné, Karin Opdecamp, Michèle Riviere, Josiane Szpirer, Claude Szpirer

Publikováno v: Nucleic Acids Research. 20:171-178

By comparing the methylation pattern of Mspl/Hpall sites in the 5' region of the mouse alpha-foetoprotein (AFP) gene of different cells (hepatoma cells, foetal and adult liver, fibroblasts), we found a correlation between gene expression and unmethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59fd0c501faade42a0fa16b514695c9
https://doi.org/10.1093/nar/20.2.171

X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina

Autor: William A. Harris, Eric Bellefroid, Karin Opdecamp, Karen Butler, Muriel Perron

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1999, 96 (26), pp.14996-5001. ⟨10.1073/pnas.96.26.14996⟩

Xath3 encodes a Xenopus neuronal-specific basic helix–loop–helix transcription factor related to the Drosophila proneural factor atonal. We show here that Xath3 acts downstream of X-ngnr-1 during neuronal differentiation in the neural plate and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5cd7d55b2ef8777adf001fc4984b22
https://hal.archives-ouvertes.fr/hal-00740522

Mutation at the anophthalmic white locus in Syrian hamsters: haploinsufficiency in the Mitf gene mimics human Waardenburg syndrome type 2

Autor: Hua Li, Heinz Arnheiter, Lori Beth Swenson, Atsuo Nakayama, Colin A. Hodgkinson, Thomas M Glaser, Karin Opdecamp, James H. Asher

Publikováno v: Human molecular genetics. 7(4)

Mutations in MITF (microphthalmia transcription factor) cause Waardenburg syndrome type 2 (WS2A) in humans, an autosomal dominant disorder consisting of deafness and hypopigmentation. Phenotypes vary significantly within WS2 pedigrees, and there is g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7577d810f0c33a34ae53cb309780ba16
https://pubmed.ncbi.nlm.nih.gov/9499424