Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karin M. Rothgiesser"'
Autor:
Marcus Vetter, Karin M Rothgiesser, Qiyu Li, Hanne Hawle, Wolfgang Schönfeld, Karin Ribi, Salome Riniker, Roger von Moos, Andreas Trojan, Elena Kralidis, Mathias Fehr, Andreas Müller, Beat Thürlimann
Publikováno v:
Endocrine Oncology, Vol 2, Iss 1, Pp 9-18 (2023)
Objective: CR1447, a novel transdermal formulation of 4-hydroxytestosterone, has aromatase-inhibiting and androgen receptor (AR)-modulating properties (IC50 4.4 nM) with antitumor effects against AR-positive tumor cells in vitro. This trial investiga
Externí odkaz:
https://doaj.org/article/ee02a98a152e445a96fded14df8d50d3
Autor:
Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa
Publikováno v:
Endocrine Connections, Vol 6, Iss 7, Pp 549-556 (2017)
CR1447 (4-hydroxytestosterone, 4-OHT) binds to the androgen receptor and has antiproliferative activity in both ER-positive and ER-negative/AR-positive breast cancer cells in preclinical studies. The objective of this first-in man trial was to evalua
Externí odkaz:
https://doaj.org/article/c9dddec557f8412bb8c5901ee09bbf31
Autor:
Marcus Vetter, Karin M Rothgiesser, Qiyu Li, Hanne Hawle, Wolfgang Schönfeld, Karin Ribi, Salome Riniker, Roger von Moos, Andreas Trojan, Elena Kralidis, Mathias Fehr, Andreas Müller, Beat Thürlimann
Publikováno v:
Endocrine Oncology. 2:9-18
Objective CR1447, a novel transdermal formulation of 4-hydroxytestosterone, has aromatase-inhibiting and androgen receptor (AR)-modulating properties (IC504.4 nM) with antitumor effects against AR-positive tumor cells in vitro. This trial investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77387bd7815f83bdf263059e77ea1972
https://doi.org/10.1530/eo-21-0009
https://doi.org/10.1530/eo-21-0009
Publikováno v:
Journal of Cell $science
NF-κB regulates the expression of a large number of target genes involved in the immune and inflammatory response, apoptosis, cell proliferation, differentiation and survival. In this study, we identified SIRT2 as a deacetylase of the transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d42a5870e435011d209fcdd3e75b97
http://jcs.biologists.org/content/123/24/4251.long
http://jcs.biologists.org/content/123/24/4251.long
Autor:
Christine Buerki, Monika Fey, Michael O. Hottiger, Heather Owen, Hubert Rehrauer, Karin M. Rothgiesser, William S. Lane, Taras Valovka
Publikováno v:
Nucleic Acids Research
Nuclear factor kappaB (NF-kappaB) plays an important role in the transcriptional regulation of genes involved in immunity and cell survival. We show here in vitro and in vivo acetylation of RelA/p65 by p300 on lysine 314 and 315, two novel acetylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4288a36863e7cbfd05e35216d86eac
https://doi.org/10.1093/nar/gkn003
https://doi.org/10.1093/nar/gkn003
Autor:
Karin M. Rothgiesser, Jan Borén, Michael W. McBurney, Nicola Schäfer, Lucia Rohrer, Ulf Landmesser, Thomas F. Lüscher, Michael O. Hottiger, Sokrates Stein, Christine Lohmann, Burkhard Becher, Christian M. Matter, Janin Hofmann, Christian Besler
Publikováno v:
European Heart Journal
Aims Endothelial activation, macrophage infiltration, and foam cell formation are pivotal steps in atherogenesis. Our aim in this study was to analyse the role of SIRT1, a class III deacetylase with important metabolic functions, in plaque macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69701ce6384ff0d6859fffd3474da76
https://www.zora.uzh.ch/id/eprint/34892/
https://www.zora.uzh.ch/id/eprint/34892/
Publikováno v:
Journal of molecular biology
Coactivator-associated arginine methyltransferase 1 (CARM1) belongs to the protein arginine methyltransferase family. It was reported to methylate histone as well as non-histone proteins and thus to be involved in transcriptional activation and mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff7d33ea50cdfb3edafb5a37a9ed5be
https://pubmed.ncbi.nlm.nih.gov/19769987
https://pubmed.ncbi.nlm.nih.gov/19769987
Publikováno v:
BMC Genomics, Vol 11, Iss 1, p 22 (2010)
BMC Genomics
BMC Genomics
Background NF-κB regulates the expression of a large number of target genes involved in the immune and inflammatory response, apoptosis, cell proliferation, differentiation and survival. We have earlier reported that p65, a subunit of NF-κB, is ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd9f7eefb37d5bf9faa1477a3acd4f8