Výsledky vyhledávání - "Karin M. Luens"

Optimization of Retroviral Gene Transduction of Mobilized Primitive Hematopoietic Progenitors by Using Thrombopoietin, Flt3, and Kit Ligands and RetroNectin Culture

Autor: Robert J. Tushinski, Karin M. Luens, Michelle Burton, Liang Jin, L J Murray, Beth L Hill, Sean P. Forestell, Jingyi Chen

Publikováno v: Human Gene Therapy. 10:1743-1752

We have investigated the ability of several cytokine combinations to improve retrovirus-mediated transduction of human primitive hematopoietic progenitors (PHPs) from mobilized peripheral blood (MPB). Retroviral infection of CD34+ cells was performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bc1537f1b84aa259fc4ca4082ec55a
https://doi.org/10.1089/10430349950017428

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Thrombopoietin, kit Ligand, and flk2/flt3 Ligand Together Induce Increased Numbers of Primitive Hematopoietic Progenitors From Human CD34+Thy-1+Lin− Cells With Preserved Ability to Engraft SCID-hu Bone

Autor: Karin M. Luens, Marilyn Travis, Ben P. Chen, Roland Scollay, L J Murray, Beth L Hill

Publikováno v: Blood. 91:1206-1215

CD34+Thy-1+Lin− cells are enriched for primitive hematopoietic progenitor cells (PHP), as defined by the cobblestone area-forming cell (CAFC) assay, and for bone marrow (BM) repopulating hematopoietic stem cells (HSC), as defined by the in vivo SCI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecb24129bd9bf47fde5640578eb70efa
https://doi.org/10.1182/blood.v91.4.1206

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Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells

Autor: Karin M. Luens, Spencer Wu, Edward Bruno, Judy Young, Lesley J. Murray, Mark Phillip Backer

Publikováno v: Blood. 88:1619-1631

Thrombopoietin (TPO) or MpI ligand is known to stimulate megakaryocyte (MK) proliferation and differentiation. To identify the earliest human hematopoietic cells on which TPO acts, we cultured single CD34+Thy- 1+Lin- adult bone marrow cells in the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43984aa27aeb159521b3be6705b972f5
https://doi.org/10.1182/blood.v88.5.1619.1619

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Hierarchical Structure of Human Megakaryocyte Progenitor Cells

Autor: Ronald Hoffman, Karin M. Luens, Judy Young, Leslie J. Murray, Edward Bruno

Publikováno v: Stem Cells. 14:75-81

Megakaryocytopoiesis is a complex bio- logical process involving a series of cellular events that begins with the pluripotent hematopoietic stem cell and ultimately results in the biogenesis of platelets. A hierarchy of megakaryocyte (MK) pro- genito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d10910de996f6d0d45bf82e1a6d106
https://doi.org/10.1002/stem.5530140709

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Quantitation of the proliferative potential of highly enriched human primitive hematopoietic progenitor cells using a stroma-free limiting dilution assay with automated scoring

Autor: Roland Scollay, Karin M. Luens, Marilyn Travis, S. Wu, Beth L Hill, L. Osborne, Judy Carol Young

Publikováno v: Cytotherapy. 1(2)

Background Increasing use of phenotypically-enriched stem cell populations for clinical hematopoietic transplants has led to an urgent demand for a reliable, rapid and simple functional assay which would provide an estimation of the reconstituting po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445953998d4749fa6c262c7077928f8c
https://pubmed.ncbi.nlm.nih.gov/19746592

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Thrombopoietin, flt3, and kit ligands together suppress apoptosis of human mobilized CD34+ cells and recruit primitive CD34+ Thy-1+ cells into rapid division

Autor: Karin M. Luens, Linda J Osborne, Judy Carol Young, L J Murray, Beth L Hill, Roland Scollay

Publikováno v: Experimental hematology. 27(6)

Various combinations of cytokines have profoundly different effects on inhibition of apoptosis and stimulation of self-renewal division of hematopoietic stem cells (HSC) in short-term, ex vivo culture. Our goal was to quantitate expansion of cells wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abe2e0c864ab732403fd129d7c42c26
https://pubmed.ncbi.nlm.nih.gov/10378891

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