Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Karin M. J. Koolen"'
Autor:
Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M. J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito
Externí odkaz:
https://doaj.org/article/5a569da9aa694e86aa5e04aa0c21ba75
Autor:
Catherin Marin-Mogollon, Ahmed M. Salman, Karin M. J. Koolen, Judith M. Bolscher, Fiona J. A. van Pul, Shinya Miyazaki, Takashi Imai, Ahmad Syibli Othman, Jai Ramesar, Geert-Jan van Gemert, Hans Kroeze, Severine Chevalley-Maurel, Blandine Franke-Fayard, Robert W. Sauerwein, Adrian V. S. Hill, Koen J. Dechering, Chris J. Janse, Shahid M. Khan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Transgenic malaria parasites expressing fluorescent and bioluminescent proteins are valuable tools to interrogate malaria-parasite biology and to evaluate drugs and vaccines. Using CRISPR/Cas9 methodology a transgenic Plasmodium falciparum (Pf) NF54
Externí odkaz:
https://doaj.org/article/74b4180130ae4557a1333d268408eb0a
Autor:
Angelika Sturm, Martijn W Vos, Rob Henderson, Maarten Eldering, Karin M J Koolen, Avinash Sheshachalam, Guido Favia, Kirandeep Samby, Esperanza Herreros, Koen J Dechering
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001426 (2021)
This work addresses the need for new chemical matter in product development for control of pest insects and vector-borne diseases. We present a barcoding strategy that enables phenotypic screens of blood-feeding insects against small molecules in mic
Externí odkaz:
https://doaj.org/article/f19a3093d2e9447aaa331fa4f81e6a93
Autor:
Patrick A. M. Jansen, Taco W. A. Kooij, Martijn W. Vos, Manuel Llinás, Floris P. J. T. Rutjes, Sergio Wittlin, Gabrielle A. Josling, Iñigo Angulo-Barturen, Stacy A. Reeves, Julie M. J. Verhoef, Karin M. J. Koolen, Erik L. Allman, Karen Miller, Helmi Pett, Suzanne Jackowski, Judith M. Bolscher, Robert W. Sauerwein, L. E. De Vries, María Belén Jiménez-Díaz, Richard H. Blaauw, Peter N. M. Botman, Graham P. Trevitt, Christien A. Beuckens-Schortinghuis, Brice Campo, Christian Scheurer, Sibylle Sax, Koen J. Dechering, Pedro H. H. Hermkens, Roger Bonnert, Christoph Fischli, Joost Schalkwijk
Publikováno v:
Science Translational Medicine. 14
Autor:
Guido Favia, Herreros E, Martijn W. Vos, Kirandeep Samby, Angelika S, Maarten Eldering, Sheshachalam A, Karin M. J. Koolen, Henderson R, Koen J. Dechering
This work addresses the need for new chemical matter in product development for control of pest insects and vector-borne diseases. We present a barcoding strategy that enables phenotypic screens of blood-feeding insects against small molecules in mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f0b3a0fff60e27ed63481ba3dc0f64e
https://doi.org/10.1101/2021.09.29.462277
https://doi.org/10.1101/2021.09.29.462277
Autor:
Julie M. J. Verhoef, Rosemary Rochford, Philip J. Rosenthal, Graham P. Trevitt, Patrick K Tumwebaze, Barcelo C, Manuel Llinás, Jacquin C. Niles, Koen J. Dechering, Henderson R, Roger Bonnert, Dhelio Batista Pereira, Anna Caroline Campos Aguiar, Huijs T, Judith M. Bolscher, David A. Fidock, Tomas Yeo, Robert W. Sauerwein, Pasaje Cfa, Jake Baum, Patrick A. M. Jansen, Brice Campo, Roland A. Cooper, Taco W. A. Kooij, de Vries Le, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, Francisco J. Gamo, Josefine Striepen, Pedro H. H. Hermkens, Sergio Wittlin, Rafael Victorio Carvalho Guido, Kelly Rubiano, Justin Munro, Fernandez Bc, Laura M. Sanz, Karin M. J. Koolen, J. Schalkwijk, Alisje Churchyard
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (ACS) inhibitor to enter preclinical development. Our studies d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defffb247aaafa1d1e8ba557aa91a1d8
https://doi.org/10.1101/2021.05.12.443866
https://doi.org/10.1101/2021.05.12.443866
Autor:
Petr Volf, Katerina Pruzinova, Matthew S. Tremblay, Robert W. Sauerwein, Arnab Chatterjee, Angelika Sturm, Baiyuan Yang, Teun Bousema, Neil M. Ferguson, Hans-Peter Duerr, Maarten Eldering, Graham P. Trevitt, John Wisler, Constantianus J. M. Koenraadt, Magdalena Jancarova, Koen J. Dechering, Pauline Ambrose, Rosemary Susan Lees, Hannah C Slater, Peter G. Schultz, Karin M. J. Koolen, Miglianico Marie
Publikováno v:
Proceedings of the National Academy of Sciences USA, 115, 29, pp. E6920-E6926
Proceedings of the National Academy of Sciences USA, 115, E6920-E6926
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America 115 (2018) 29
Proceedings of the National Academy of Sciences of the United States of America, 115(29), E6920-E6926
E6926
E6920
Proceedings of the National Academy of Sciences USA, 115, E6920-E6926
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America 115 (2018) 29
Proceedings of the National Academy of Sciences of the United States of America, 115(29), E6920-E6926
E6926
E6920
Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed Anopheles, Ae
Autor:
Patrick A. M. Jansen, Taco W. A. Kooij, Helmi Pett, Judith M. Bolscher, Suzanne Jackowski, Laura E. de Vries, María Belén Jiménez-Díaz, Brice Campo, Martijn W. Vos, Karin M. J. Koolen, Roger Bonnert, Stacy A. Reeves, Christoph Fischli, Christien A. Beuckens-Schortinghuis, Peter N. M. Botman, Koen J. Dechering, Manuel Llinás, Gabrielle A. Josling, Robert W. Sauerwein, Joost Schalkwijk, Julie M. J. Verhoef, Sergio Wittlin, Karen Miller, Pedro H. H. Hermkens, Graham P. Trevitt, Iñigo Angulo-Barturen, Erik L. Allman, Floris P. J. T. Rutjes, Richard H. Blaauw, Christian Scheurer, Sibylle Sax
Publikováno v:
Science Translational Medicine, 11(510)
Science Translational Medicine, 11, 510, pp. 1-16
Science Translational Medicine, 11, 1-16
Science Translational Medicine 11 (2019) 510
Science Translational Medicine, 11, 510, pp. 1-16
Science Translational Medicine, 11, 1-16
Science Translational Medicine 11 (2019) 510
Malaria eradication is critically dependent on new therapeutics that target resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage Plasmodium falciparum p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef5f25c8bda84ba537ac40b18f93959
https://research.wur.nl/en/publications/antimalarial-pantothenamide-metabolites-target-acetyl-coenzyme-a-
https://research.wur.nl/en/publications/antimalarial-pantothenamide-metabolites-target-acetyl-coenzyme-a-
Autor:
Catherin, Marin-Mogollon, Ahmed M, Salman, Karin M J, Koolen, Judith M, Bolscher, Fiona J A, van Pul, Shinya, Miyazaki, Takashi, Imai, Ahmad Syibli, Othman, Jai, Ramesar, Geert-Jan, van Gemert, Hans, Kroeze, Severine, Chevalley-Maurel, Blandine, Franke-Fayard, Robert W, Sauerwein, Adrian V S, Hill, Koen J, Dechering, Chris J, Janse, Shahid M, Khan
Publikováno v:
Frontiers in cellular and infection microbiology. 9
Transgenic malaria parasites expressing fluorescent and bioluminescent proteins are valuable tools to interrogate malaria-parasite biology and to evaluate drugs and vaccines. Using CRISPR/Cas9 methodology a transgenic
Autor:
Daniel E. Neafsey, Dyann F. Wirth, Jon Clardy, Arvind Sharma, Ping S. Lui, Anne-Marie Zeeman, Sean Eckley, Yvonne Van Gessel, Mathias Wawer, Matthias Marti, Elizabeth A. Winzeler, Elamaran Meibalan, Nobutaka Kato, Benito Munoz, Emily R. Derbyshire, Stuart L. Schreiber, Marshall L. Morningstar, Jeremy R. Duvall, Clemens H. M. Kocken, Eli L. Moss, Bennett C. Meier, Joshua A. Bittker, Vicky M. Avery, Manmohan Sharma, John E. Burke, Eamon Comer, Jacob A. McPhail, Maurice A. Itoe, Jessica Bastien, Nicolas M. B. Brancucci, Branko Mitasev, David Clarke, Timothy A. Lewis, Victoria C. Corey, Sandra Duffy, Tomoyo Sakata-Kato, Fabian Gusovsky, Sandra March, Takashi Yoshinaga, Gillian L. Dornan, Flaminia Catteruccia, Morgane Sayes, Emily Lund, Christina Scherer, Sangeeta N. Bhatia, Michael Foley, Amit Sharma, Amanda K. Lukens, Paul A. Clemons, Koen J. Dechering, Karin M. J. Koolen, Micah Maetani
Publikováno v:
Nature
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection