Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes.

Autor: Karin M Streifel, Albert L Gonzales, Briana De Miranda, Rola Mouneimne, Scott Earley, Ronald Tjalkens

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e110996 (2014)

Dopaminergic nuclei in the basal ganglia are highly sensitive to damage from oxidative stress, inflammation, and environmental neurotoxins. Disruption of adenosine triphosphate (ATP)-dependent calcium (Ca2+) transients in astrocytes may represent an

Externí odkaz: https://doaj.org/article/615a717028254b5d89024327020167ef

Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain

Autor: Karin M. Streifel, Casey A. Boosalis, Pamela J. Lein, Matthew Bruce, Luke Heuer, Shuyang Li, Judy Van de Water, Danielle J Harvey, Eduardo A. González

Publikováno v: Journal of neuroinflammation, vol 16, iss 1
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)

Background Neuroinflammation can modulate brain development; however, the influence of an acute peripheral immune challenge on neuroinflammatory responses in the early postnatal brain is not well characterized. To address this gap in knowledge, we ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b4f8473ab59781f41b9cf41882dc78
https://escholarship.org/uc/item/0cm1f2kz

BDE-47 and BDE-49 inhibit axonal growth in primary rat hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms

Autor: Linley Mangini, Pamela J. Lein, Hao Chen, Vikrant Singh, Karin M. Streifel, Dongren Yang, Heike Wulff

Publikováno v: Chen, H; Streifel, KM; Singh, V; Yang, D; Mangini, L; Wulff, H; et al.(2017). BDE-47 and BDE-49 inhibit axonal growth in primary rat hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicological Sciences, 156(2), 375-386. doi: 10.1093/toxsci/kfw259. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/15j6965h

© The Author 2016. Polybrominated diphenyl ethers (PBDEs) are widespread environmental contaminants associated with adverse neurodevelopmental outcomes in children and preclinical models; however, the mechanisms by which PBDEs cause developmental ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935dea9ebe0e0969aa28940b34474d6b
http://www.escholarship.org/uc/item/15j6965h

Gene Deletion of nos2 Protects Against Manganese-Induced Neurological Dysfunction in Juvenile Mice

Autor: Karin M. Streifel, Marie E. Legare, Ronald B. Tjalkens, William H. Hanneman, Julie A. Moreno

Publikováno v: Toxicological Sciences. 126:183-192

The mechanisms underlying cognitive and neurobehavioral abnormalities associated with childhood exposure to manganese (Mn) are not well understood but may be influenced by neuroinflammatory activation of microglia and astrocytes that results in nitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc689f9c3ca9b0d557fa60af50a5df41
https://doi.org/10.1093/toxsci/kfr335

Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons

Autor: Pamela J. Lein, William R. Mundy, Karin M. Streifel, Hao Chen, Dongren Yang, Joshua A. Harrill

Publikováno v: Molecular brain, vol 8, iss 1
Harrill, JA; Chen, H; Streifel, KM; Yang, D; Mundy, WR; & Lein, PJ. (2015). Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons. Molecular Brain, 8(1). doi: 10.1186/s13041-015-0099-9. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/79f886j9
Molecular Brain

© 2015 Harrill et al.; licensee BioMed Central. Background: Synaptogenesis is a critical neurodevelopmental process whereby pre- and postsynaptic neurons form apposed sites of contact specialized for chemical neurotransmission. Many neurodevelopment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fb501234a1ccc3514ae1ead94a41b2
https://escholarship.org/uc/item/79f886j9