Supplementary Data from Efficient Tumor Clearance and Diversified Immunity through Neoepitope Vaccines and Combinatorial Immunotherapy

Autor: Duane H. Hamilton, Jeffrey Schlom, Kayvan Niazi, Patrick Soon-Shiong, Shahrooz Rabizadeh, John H. Lee, Lars Rohlin, Peter Ordentlich, Zhen Su, John Z. Sanborn, Claudia Palena, Sofia R. Gameiro, Andrew Nguyen, Kristin C. Hicks, Stephen C. Benz, Karin L. Lee

Supplementary figures and tables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76402d3621e33d3448c35be905e61c29
https://doi.org/10.1158/2326-6066.22542444

Data from Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy

Autor: Sofia R. Gameiro, Jeffrey Schlom, Patrick Soon-Shiong, Shahrooz Rabizadeh, Frank R. Jones, Peter Ordentlich, William D. Figg, James W. Hodge, Duane H. Hamilton, Karin L. Lee, Karin M. Knudson, Kristin C. Hicks

Purpose:Immunotherapy has demonstrated clinical efficacy in subsets of patients with solid carcinomas. Multimodal therapies using agents that can affect different arms of the immune system and/or tumor microenvironment (TME) might increase clinical r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257ac866c6a46a82c5d0490c769eeba2
https://doi.org/10.1158/1078-0432.c.6528504.v1

Combination therapies utilizing neoepitope-targeted vaccines

Autor: Duane H. Hamilton, Jeffrey Schlom, Karin L. Lee

Publikováno v: Cancer Immunology, Immunotherapy

Clinical successes have been achieved with checkpoint blockade therapy, which facilitates the function of T cells recognizing tumor-specific mutations known as neoepitopes. It is a reasonable hypothesis that therapeutic cancer vaccines targeting neoe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e591172d7aef8d9947e67651faa0ac1
http://europepmc.org/articles/PMC7979579

Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy

Autor: Charles J. Vaske, Stephen C. Benz, Andreas Mackensen, Duane H. Hamilton, Andrew Nguyen, J. Zachary Sanborn, Sascha Kretschmann, James L. Gulley, Peter A. Fasching, Edith D van der Meijden, Shahrooz Rabizadeh, Marieke Griffioen, Kayvan Niazi, Patricia Spilman, Matthias Ruebner, Matthias W. Beckmann, Karin L. Lee, H Reimann, Patrick Soon-Shiong, Anita N. Kremer, Alexander Hein, Jeffrey Schlom, Judith Bausenwein

Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for ImmunoTherapy of Cancer, 9(6). BMJ PUBLISHING GROUP

BackgroundTherapeutic regimens designed to augment the immunological response of a patient with breast cancer (BC) to tumor tissue are critically informed by tumor mutational burden and the antigenicity of expressed neoepitopes. Herein we describe a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee3cec741e0d608adb115ccb0760da6
https://hdl.handle.net/1887/3279922

Plant Virus-Based Nanotechnologies

Autor: Karin L. Lee, Amy M. Wen, Nicole F. Steinmetz

Publikováno v: Women in Nanotechnology ISBN: 9783030199500

Nanoscale engineering is revolutionizing disease detection and prevention. Viruses have made a remarkable contribution to these developments because they can function as prefabricated nanoparticles that have naturally evolved to deliver cargos to cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bca128f495b01043b8ba922ca4f9898
https://doi.org/10.1007/978-3-030-19951-7_5