Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Karin Johanna Ferrari"'
Autor:
Simone Tamburri, Eleonora Ponzo, Federico Rossi, Marika Zanotti, Simona Rodighiero, Diego Pasini, Daria Manganaro, Karin Johanna Ferrari, Daniel Fernández-Pérez, Eric Conway
Publikováno v:
Molecular Cell
Summary BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed4cfe3006157ef0b911f7e9c253c92
https://hdl.handle.net/2434/946749
https://hdl.handle.net/2434/946749
Autor:
Pasquale Conforti, Karin Johanna Ferrari, Tiziana Bonaldi, Marika Zanotti, Daniel Fernández-Pérez, Cecilia Toscani, Diego Pasini, Roberta Noberini, Alessandra Rossi, Simona Amato, Simone Tamburri
Publikováno v:
Nucleic Acids Research
The proteolytic cleavage of histone tails, also termed histone clipping, has been described as a mechanism for permanent removal of post-translational modifications (PTMs) from histone proteins. Such activity has been ascribed to ensure regulatory fu
Autor:
Eric Conway, Federico Rossi, Daria Manganaro, Diego Pasini, Karin Johanna Ferrari, Simona Rodighiero, Simone Tamburri, Ponzo E, Marika Zanotti, Daniel Fernández-Pérez
BAP1 is recurrently mutated or deleted in a large number of diverse cancer types, including mesothelioma, uveal melanoma and hepatocellular cholangiocarcinoma. BAP1 is the catalytic subunit of the Polycomb Repressive De-Ubiquitination complex (PR-DUB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bee35bc4a48cc93dc4363c7e0d1299
https://doi.org/10.1101/2020.12.10.419309
https://doi.org/10.1101/2020.12.10.419309
Autor:
Karin Johanna Ferrari, Nadia Panera, Luca Miele, Rossella Rota, Ezio Giorda, Marco Chierici, Elena Carcarino, Annalisa Crudele, Clara Balsano, Cristiano De Stefanis, Valentina D'Oria, Valerio Nobili, Manuela Porru, Ilaria Romito, Simona Artuso, Cesare Furlanello, Carlo Leonetti, Diego Pasini, Erica Villa, Daniela Gnani, Sara Ceccarelli, Anna Alisi, Franco Locatelli
Publikováno v:
Cell Death and Differentiation
Hepatocellular carcinoma (HCC) is the most common type of liver cancer in humans. The focal adhesion tyrosine kinase (FAK) is often over-expressed in human HCC and FAK inhibition may reduce HCC cell invasiveness. However, the anti-oncogenic effect of
Autor:
Tiziana Bonaldi, Diego Pasini, Marika Zanotti, Karin Johanna Ferrari, Simone Tamburri, Daniel Fernández-Pérez, Elisa Lavarone, Andrea Scelfo, Monica Soldi
Publikováno v:
Molecular Cell
Summary Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) control cell identity by establishing facultative heterochromatin repressive domains at common sets of target genes. PRC1, which deposits H2Aub1 through the E3 ligases RING1A/B, forms six
Autor:
Stephany Fiore, Antonino Sottile, Silvia Giordano, Marco Volante, Filippo Minutolo, Daniel Fernández-Pérez, Maria Apicella, Elisa Giannoni, Claudio Isella, Paolo M. Comoglio, Karin Johanna Ferrari, Simona Corso, Enzo Medico, Diego Pasini, Paola Chiarugi, Carlotta Granchi, Filippo Pietrantonio
Summary The microenvironment influences cancer drug response and sustains resistance to therapies targeting receptor-tyrosine kinases. However, if and how the tumor microenvironment can be altered during treatment, contributing to resistance onset, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af070831cbce3ff59277902ce4b3a702
http://hdl.handle.net/2318/1691738
http://hdl.handle.net/2318/1691738
Autor:
Karin Johanna Ferrari, Wolfgang Fischle, Tiziana Bonaldi, Alessandro Cuomo, Diego Pasini, Alexandra Stützer, Iros Barozzi, Sriganesh Jammula, Andrea Scelfo
Publikováno v:
Molecular Cell
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene transcription. H3K27 is also present in mono- and dimethylated states; how
Autor:
Diego Pasini, Pier Giuseppe Pelicci, Alessandra Rossi, Karin Johanna Ferrari, Sriganesh Jammula, Andrea Piunti, Luca Mazzarella, Andrea Scelfo, Fulvio Chiacchiera
Publikováno v:
Science Advances
The Polycomb complex PRC1 is a gatekeeper of leukemic cell identity in the presence of distinct oncogenic signals.
Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular a
Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1809a75ae0b09e8649285124e1221e2e
http://hdl.handle.net/11572/224843
http://hdl.handle.net/11572/224843
Publikováno v:
Molecular Cell. 64:637-638
Two studies published in this issue of Molecular Cell (Beringer et al., 2016; Liefke et al., 2016) characterize the novel interaction of EPOP with Elongin BC in regulating gene transcription at both H3K4me3-broad active and H3K27me3 Polycomb-represse
Autor:
Karin Johanna Ferrari, Diego Pasini
Publikováno v:
Current pharmaceutical design. 19(4)
Cell type specification, transcription factor binding site selection and transcriptional regulation are specific processes that require a fine regulation that cannot be simply explained by the mere DNA sequence. Similarly, genome stability, damage re