Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Karin J Purdie"'
Autor:
Kevin Lai, Catherine A Harwood, Karin J Purdie, Charlotte M Proby, Irene M Leigh, Namita Ravi, Thaddeus W Mully, Lionel Brooks, Priscilla M Sandoval, Michael D Rosenblum, Sarah T Arron
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188272 (2017)
Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the understanding of AFX through whole-exome and RNA seque
Externí odkaz:
https://doaj.org/article/e97ef3f1d0b9437da097400ec0d34427
Autor:
Arucha L Ekeowa-Anderson, Karin J Purdie, Karen Gibbon, Carolyn R Byrne, Jeffrey M Arbeit, Catherine A Harwood, Ryan F L O'Shaughnessy
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38608 (2012)
Anogenital malignancy has a significant association with high-risk mucosal alpha-human papillomaviruses (alpha-PV), particularly HPV 16 and 18 whereas extragenital SCC has been linked to the presence of cutaneous beta and gamma-HPV types. Vulval skin
Externí odkaz:
https://doaj.org/article/10fb38da83e8489d8c9864df59090379
Autor:
Gareth J. Inman, Irene M. Leigh, Jun Wang, Findlay Bewicke-Copley, Chinedu Anthony Anene, Jason Thomson, Catherine A. Harwood, Ai Nagano, Abha Gulati, Charlotte M. Proby, Karin J. Purdie
Publikováno v:
The Journal of investigative dermatology. 141(7)
Actinic keratoses (AKs) are lesions of epidermal keratinocyte dysplasia and are precursors for invasive cutaneous squamous cell carcinoma (cSCC). Identifying the specific genomic alterations driving the progression from normal skin to skin with AK to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35de0d3e2bd94f2f287f0646bd5192bc
https://pubmed.ncbi.nlm.nih.gov/34167719
https://pubmed.ncbi.nlm.nih.gov/34167719
Autor:
Ai Nagano, Gareth J. Inman, Viviana Mannella, Dimitris Athineos, Sakinah Hassan, Irene M. Leigh, Celine Pourreyron, Karin J. Purdie, Charlotte M. Proby, Sandeep Dhayade, Nikol Mladkova, Catherine A. Harwood, M. Caley, Jun Wang, Karen Blyth
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3428 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 14
International Journal of Molecular Sciences
Volume 20
Issue 14
Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with increasing morbidity and mortality, with limited treatment options for advanced disease. Future improvements in targeted therapy will rely on advances in genomic/tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff76627ae66485bab9f7ba9b6b5b4329
https://www.mdpi.com/1422-0067/20/14/3428
https://www.mdpi.com/1422-0067/20/14/3428
Autor:
Karin J. Purdie, Koen D. Quint, Nicholas Francis, Catherine A. Harwood, Frances Gotch, Ann-Margaret Little, Finnuala Baker, Steven G.E. Marsh, D. Hawkins, R. Meys, David Asboe, Christopher B Bunker, Maurits N. C. de Koning
Publikováno v:
Journal of Infectious Diseases, 213(11), 1717-1724
A proportion of human immunodeficiency virus (HIV)-infected patients develop persistent, stigmatizing human papillomavirus (HPV)-related cutaneous and genital warts and anogenital (pre)cancer. This is the first study to investigate immunogenetic vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cc88fd2a0b31d846f322354b9d55cf
https://doi.org/10.1093/infdis/jiw038
https://doi.org/10.1093/infdis/jiw038
Autor:
Irene M. Leigh, Charlotte M. Proby, Gareth J. Inman, Mariet C.W. Feltkamp, Andrew P. South, Hasan Rizvi, Els van der Meijden, Mary Sommerlad, Heather Griffin, John Doorbar, Catherine A. Harwood, Karin J. Purdie
Publikováno v:
Frontiers in Microbiology, 9
Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology
Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology
Background: Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b28185795ac7ecd3a3dcc6a12e3079f
https://hdl.handle.net/1887/78050
https://hdl.handle.net/1887/78050
Autor:
Hasan Rizvi, Ankit Kumar Patel, Paola Ostano, Daniele Bergamaschi, Catherine A. Harwood, Baki Akgül, Martin Hufbauer, Giovanna Chiorino, Deborah J. Robinson, Jun Wang, Karin J. Purdie
Publikováno v:
The Journal of investigative dermatology. 139(8)
Keratinocyte skin cancer, comprising cutaneous squamous (cSCC) and basal cell carcinoma, is the most common malignancy in the United Kingdom. P53 is frequently mutated in cSCC. iASPP is a key inhibitor of p53 and NF-κB signaling pathways and has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662cf6867af0e84d8775c5863ab74587
https://pubmed.ncbi.nlm.nih.gov/30710576
https://pubmed.ncbi.nlm.nih.gov/30710576
Autor:
Sarah T. Arron, Jasbani H.S. Dayal, Angela McHugh, Andrew P. South, Catherine A. Harwood, Nicoline Y. den Breems, Dylan J. Xue, Irene M. Leigh, Charlotte M. Proby, Stephen Watt, Karin J. Purdie, Michelle Dimon
Publikováno v:
The American Journal of Pathology. 185:2354-2363
NF-κB signaling plays a crucial role in regulating proliferation and differentiation in the epidermis. Alterations in the NF-κB pathway can lead to skin pathologies with a significant burden to human health such as psoriasis and cutaneous squamous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d243fe4ea8f7db04a514894a01e0284
https://doi.org/10.1016/j.ajpath.2015.05.018
https://doi.org/10.1016/j.ajpath.2015.05.018
Autor:
Aidan M, Rose, Lindsay C, Spender, Christopher, Stephen, Alastair, Mitchell, William, Rickaby, Susan, Bray, Alan T, Evans, Jasbani, Dayal, Karin J, Purdie, Catherine A, Harwood, Charlotte M, Proby, Irene M, Leigh, Philip J, Coates, Gareth J, Inman
Publikováno v:
Oncotarget
The incidence of cutaneous squamous cell carcinoma (cSCC) is rising. Whilst the majority are cured surgically, aggressive metastatic cSCC carry a poor prognosis. Inactivating mutations in transforming growth factor beta (TGF-β) receptors have been i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7cf7ae6e692a9ea3307a1a10356d01cb
https://pubmed.ncbi.nlm.nih.gov/29581863
https://pubmed.ncbi.nlm.nih.gov/29581863
Autor:
Gareth J, Inman, Jun, Wang, Ai, Nagano, Ludmil B, Alexandrov, Karin J, Purdie, Richard G, Taylor, Victoria, Sherwood, Jason, Thomson, Sarah, Hogan, Lindsay C, Spender, Andrew P, South, Michael, Stratton, Claude, Chelala, Catherine A, Harwood, Charlotte M, Proby, Irene M, Leigh
Publikováno v:
Nature Communications
Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50 mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 primary cSCC tumours, comprising 20 well-differentiated and 20 moderately/poorly differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c136f275cf268380b56168b99dc959d
https://pubmed.ncbi.nlm.nih.gov/30202019
https://pubmed.ncbi.nlm.nih.gov/30202019