Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Karin J Metzner"'
Autor:
Nadia Neuner-Jehle, Marius Zeeb, Christian W Thorball, Jacques Fellay, Karin J Metzner, Paul Frischknecht, Kathrin Neumann, Christine Leeman, Andri Rauch, Marcel Stöckle, Michael Huber, Matthieu Perreau, Enos Bernasconi, Julia Notter, Matthias Hoffmann, Karoline Leuzinger, Huldrych F Günthard, Chloé Pasin, Roger D Kouyos, Swiss HIV Cohort Study (SHCS)
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012385 (2024)
The pathogenesis of HIV-1 infection is governed by a highly dynamic, time-dependent interaction between the host and the viral genome. In this study, we developed a novel systematic approach to assess the host-virus interaction, using average pairwis
Externí odkaz:
https://doaj.org/article/4c8bd76294a344a5a8d9bd33b496838f
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001010 (2020)
An often-returning question for not only HIV-1, but also other organisms, is how predictable evolutionary paths are. The environment, mutational history, and random processes can all impact the exact evolutionary paths, but to which extent these fact
Externí odkaz:
https://doaj.org/article/d83ee067ecc64c489e7516994a3109ae
Autor:
Delphine Sculier, Gilles Wandeler, Sabine Yerly, Annalisa Marinosci, Marcel Stoeckle, Enos Bernasconi, Dominique L Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J Metzner, Laurent A Decosterd, Huldrych F Günthard, Patrick Schmid, Andreas Limacher, Matthias Egger, Alexandra Calmy, Swiss HIV Cohort Study (SHCS)
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003421 (2020)
BackgroundDolutegravir (DTG)-based dual therapy is becoming a new paradigm for both the initiation and maintenance of HIV treatment. The SIMPL'HIV study investigated the outcomes of virologically suppressed patients on standard combination antiretrov
Externí odkaz:
https://doaj.org/article/cdb0b17e861342ceb7538b7856bd5606
Autor:
David Beauparlant, Peter Rusert, Carsten Magnus, Claus Kadelka, Jacqueline Weber, Therese Uhr, Osvaldo Zagordi, Corinna Oberle, Maria J Duenas-Decamp, Paul R Clapham, Karin J Metzner, Huldrych F Günthard, Alexandra Trkola
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006255 (2017)
A hallmark of HIV-1 infection is the continuously declining number of the virus' predominant target cells, activated CD4+ T cells. With diminishing CD4+ T cell levels, the capacity to utilize alternate cell types and receptors, including cells that e
Externí odkaz:
https://doaj.org/article/070d0eed8e9f43eaa673e40f269e366c
Autor:
Elizabeth P St John, Birgitte B Simen, Gregory S Turenchalk, Michael S Braverman, Isabella Abbate, Jeroen Aerssens, Olivier Bouchez, Christian Gabriel, Jacques Izopet, Karolin Meixenberger, Francesca Di Giallonardo, Ralph Schlapbach, Roger Paredes, James Sakwa, Gudrun G Schmitz-Agheguian, Alexander Thielen, Martin Victor, Karin J Metzner, Martin P Däumer, HIV-1 Alpha Study Group
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146687 (2016)
Ultra deep sequencing is of increasing use not only in research but also in diagnostics. For implementation of ultra deep sequencing assays in clinical laboratories for routine diagnostics, intra- and inter-laboratory testing are of the utmost import
Externí odkaz:
https://doaj.org/article/a4961bf50e52452a89b38a806cc6e439
Autor:
Dominique L Braun, Andri Rauch, Manel Aouri, Nina Durisch, Nadia Eberhard, Alexia Anagnostopoulos, Bruno Ledergerber, Beat Müllhaupt, Karin J Metzner, Laurent Decosterd, Jürg Böni, Rainer Weber, Jan Fehr, Swiss HIV Cohort Study
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133028 (2015)
The efficacy of first-generation protease inhibitor based triple-therapy against hepatitis C virus (HCV) infection is limited in HIV/HCV-coinfected patients with advanced liver fibrosis and non-response to previous peginterferon-ribavirin. These pati
Externí odkaz:
https://doaj.org/article/592defcac282419085300e63d729b6d5
Autor:
Valentina Vongrad, Jochen Imig, Pejman Mohammadi, Shivendra Kishore, Lukasz Jaskiewicz, Jonathan Hall, Huldrych F Günthard, Niko Beerenwinkel, Karin J Metzner
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132127 (2015)
BACKGROUND:MiRNAs and other small noncoding RNAs (sncRNAs) are key players in post-transcriptional gene regulation. HIV-1 derived small noncoding RNAs (sncRNAs) have been described in HIV-1 infected cells, but their biological functions still remain
Externí odkaz:
https://doaj.org/article/07a157720b9d4c299ef111f384c70e2b
Autor:
Francesca Di Giallonardo, Osvaldo Zagordi, Yannick Duport, Christine Leemann, Beda Joos, Marzanna Künzli-Gontarczyk, Rémy Bruggmann, Niko Beerenwinkel, Huldrych F Günthard, Karin J Metzner
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74249 (2013)
Next-generation sequencing (NGS) is a valuable tool for the detection and quantification of HIV-1 variants in vivo. However, these technologies require detailed characterization and control of artificially induced errors to be applicable for accurate
Externí odkaz:
https://doaj.org/article/cbaeb1fe1e194334a7b02f6c778379f5
Autor:
Raquel González, Antonio Maldonado, Virginia Martín, Inácio Mandomando, Victoria Fumadó, Karin J Metzner, Charfudin Sacoor, Leónides Fernández, Eusébio Macete, Pedro L Alonso, Juan M Rodríguez, Clara Menendez
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80299 (2013)
BACKGROUND: Human milk and infant gut microbiota are essential for the immune system maturation and protection against infections. There is scarce information on the microbiological composition of breast milk in general, and none from developing coun
Externí odkaz:
https://doaj.org/article/dfa427c11eaf4eb0bbc608facb075e20
Autor:
Karin J Metzner, Christine Leemann, Francesca Di Giallonardo, Christina Grube, Alexandra U Scherrer, Dominique Braun, Herbert Kuster, Rainer Weber, Huldrych F Guenthard
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21734 (2011)
In the Zurich Primary HIV infection study (ZPHI), minority drug-resistant HIV-1 variants were detected in some acutely HIV-1-infected patients prior to initiation of early antiretroviral therapy (ART). Here, we investigated the reappearance of minori
Externí odkaz:
https://doaj.org/article/f6fab6212d234b988ecc8e22b23a5590