Expanding the genetic toolbox for the obligate human pathogen Streptococcus pyogenes

Autor: Nina Lautenschläger, Katja Schmidt, Carolin Schiffer, Thomas F. Wulff, Karin Hahnke, Knut Finstermeier, Moïse Mansour, Alexander K. W. Elsholz, Emmanuelle Charpentier

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

Genetic tools form the basis for the study of molecular mechanisms. Despite many recent advances in the field of genetic engineering in bacteria, genetic toolsets remain scarce for non-model organisms, such as the obligatory human pathogen Streptococ

Externí odkaz: https://doaj.org/article/ab38edfc233547cf9549c6c011dab4ff

Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria

Autor: Gopinath Krishnamoorthy, Peggy Kaiser, Laura Lozza, Karin Hahnke, Hans-Joachim Mollenkopf, Stefan H. E. Kaufmann

Publikováno v: mBio, Vol 10, Iss 3 (2019)

ABSTRACT Mycofactocin (MFT) belongs to the class of ribosomally synthesized and posttranslationally modified peptides conserved in many Actinobacteria. Mycobacterium tuberculosis assimilates cholesterol during chronic infection, and its in vitro grow

Externí odkaz: https://doaj.org/article/d41ea91e2d8345c491431502cbe28df4

MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment

Autor: Franca Del Nonno, Ellen Heinemann, Maura Farinacci, Kellen C. Faé, Delia Goletti, Rosanna Capparelli, Jörg Schreiber, Sabine Jörg, Pedro Moura-Alves, Dagmar Oberbeck-Müller, Marco Iannaccone, Anca Dorhoi, Delia Löwe, Hans-Joachim Mollenkopf, Karin Hahnke, Geraldine Nouailles, Stefan H. E. Kaufmann

The molecular mechanisms that control innate immune cell trafficking during chronic infection and inflammation, such as in tuberculosis (TB), are incompletely understood. During active TB, myeloid cells infiltrate the lung and sustain local inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc39e66c39d4419e106cf48ce637b61a
https://doi.org/10.1172/jci67604

cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

Autor: Mingtong Ma, Anne Tuukkanen, Xiangyang Wu, Anca Dorhoi, Karin Hahnke, Siyu Liu, Marion Klemm, Dagmar Oberbeck-Mueller, Hans-Joachim Mollenkopf, Haipeng Liu, Pedro Moura-Alves, Fei Wang, Ute Guhlich-Bornhof, Anne-Britta Koehler, Gang Pei, Stefan H. E. Kaufmann, Baoxue Ge, Michael Kolbe, Yiyan Fei, Robert Hurwitz, Chenggang Zhu

Publikováno v: EMBO Reports

Cyclic dinucleotides (CDNs) are important second messenger molecules in prokaryotes and eukaryotes. Within host cells, cytosolic CDNs are detected by STING and alert the host by activating innate immunity characterized by type I interferon (IFN) resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cb6f7011bc6b7ce333631b6bd9330d
http://ora.ox.ac.uk/objects/uuid:

In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes

Autor: Emmanuelle Charpentier, Anaïs Le Rhun, Karin Hahnke, Rina Ahmed-Begrich, Anne-Laure Lécrivain, Thibaud T. Renault

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (46), pp.11814-11819. ⟨10.1073/pnas.1809663115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (46), pp.11814-11819. ⟨10.1073/pnas.1809663115⟩

mRNA decay plays an essential role in the control of gene expression in bacteria. Exoribonucleases (exoRNases), which trim transcripts starting from the 5′ or 3′ end, are particularly important to fully degrade unwanted transcripts and renew the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0862331e2e4e5c3eae0b2fc294c516f3
https://hdl.handle.net/21.11116/0000-0004-0158-821.11116/0000-0004-0156-A