Výsledky vyhledávání - "Karin Haehnel"

Efficient Correction of ELANE mutations in Primary HSPCs of Severe Congenital Neutropenia Patients Using CRISPR/Cas9 and rAVV6 HDR Repair Templates

Autor: Julia Skokowa, Benjamin Secker, Baubak Bajoghli, Karin Haehnel, Maksim Klimiankou, Benjamin Dannenmann, Malte U Ritter, Ingeborg Steiert, Karl Welte, Narges Aghaallaei, Masoud Nasri, Cornelia Zeidler, Regine Bernhard

Publikováno v: Blood. 134:1036-1036

Patients with the rare pre-leukemia bone marrow failure syndrome severe congenital neutropenia (CN) have reduced numbers of neutrophils in peripheral blood ( Up to now, the only curative therapy for CN patients that do not respond to G-CSF or with ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8dbf2d7c9195454ae271bf8135cb058d
https://doi.org/10.1182/blood-2019-131708

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Proportions of blood-borne Vd1þ and Vd2þ T-cells are associated with overall survival of melanoma patients treated with ipilimumab

Publikováno v: European Journal of Cancer
European Journal of Cancer, Elsevier, 2016, 64, pp.116-126. 〈10.1016/j.ejca.2016.06.001〉
European Journal of Cancer, Elsevier, 2016, 64, pp.116-126. ⟨10.1016/j.ejca.2016.06.001⟩
European Journal of Cancer, 2016, 64, pp.116-126. ⟨10.1016/j.ejca.2016.06.001⟩

International audience; Human γδ T-cells possess regulatory and cytotoxic capabilities, and could potentially influence the efficacy of immunotherapies. We analysed the frequencies of peripheral γδ T-cells, including their most prominent subsets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39007399e3018e64f47feb4f1b082bb
http://www.hal.inserm.fr/inserm-01408787

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No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

Autor: David Goldeck, Kristina Norman, Elisabeth Steinhagen-Thiessen, Graham Pawelec, Ilja Demuth, Karin Haehnel, Lilly Oettinger

Publikováno v: Biogerontology

Hand-grip strength is strongly correlated with measures of muscle mass and can be taken to predict morbidity and mortality. The aim of this study was to investigate the relationship between hand-grip strength and other markers associated with immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c074742bb5db9cfda5113beb961312e4
https://pubmed.ncbi.nlm.nih.gov/25906063

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Human T-cell clones in long-term culture as a model of immunosenescence

Autor: Andrea Merl, Graham Pawelec, Arnika Rehbein, Medi Adibzadeh, Karin Haehnel

Publikováno v: Immunological Reviews. 160:31-42

We have consistently observed that like other normal somatic tissue cells, human T lymphocytes manifest a finite proliferative capacity in culture in vitro. When measured in population doublings (PD), this averages about 35 PD for T-cell clones (TCC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4647f20bce87e6736bb72ec82bc7a6d1
https://doi.org/10.1111/j.1600-065x.1997.tb01025.x

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Optimization of CSF3R Mutation Detection in Severe Congenital Neutropenia and Cyclic Neutropenia Patients for Routine Diagnostics Using Next Generation Sequencing

Autor: Sabine Mellor-Heineke, Ingeborg Steiert, Karin Haehnel, Karl Welte, Julia Skokowa, Maksim Klimiankou, Cornelia Zeidler

Publikováno v: Blood. 128:3685-3685

Severe congenital neutropenia (CN) is a group of bone marrow failure syndromes characterized by absolute neutrophil counts below 0.5x109/L, susceptibility to bacterial infections and frequently associated with maturation arrest at promyelocyte stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1634d406ef9cd39ae483dedf6e6866b5
https://doi.org/10.1182/blood.v128.22.3685.3685

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Identification of two early differentiated populations within CD4+ and CD8+ TEMRA T‐cells

Autor: Evelyna Derhovanessian, Graham Pawelec, Karin Haehnel, Sven D. Koch

Publikováno v: The FASEB Journal. 22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1b3d945da0239ecbce9368b432243de
https://doi.org/10.1096/fasebj.22.1_supplement.846.10

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Infection with Cytomegalovirus but not Herpes Simplex Virus induces the accumulation of late differentiated 'senescent' T-cells in humans (39.13)

Autor: Graham Pawelec, Andrea Maier, Gerhard Jahn, Robert Beck, Karin Haehnel, Rudi Westendorp, Evelyna Derhovanessian

Publikováno v: The Journal of Immunology. 184:39.13-39.13

Infection with the persistent reactivating human cytomegalovirus (CMV) is associated with an age-associated increasing accumulation of late-differentiated CD8+ T-cells even in asymptomatic healthy carriers. It has been postulated that chronic exposur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::339d3bd34e3904b324923421b82e54e3
https://doi.org/10.4049/jimmunol.184.supp.39.13

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