Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Autor: Reginald V.C.T. van der Kwast, Laura Parma, M. Leontien van der Bent, Eva van Ingen, Fabiana Baganha, Hendrika A.B. Peters, Eveline A.C. Goossens, Karin H. Simons, Meindert Palmen, Margreet R. de Vries, Paul H.A. Quax, A. Yaël Nossent

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 932-953 (2020)

Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-

Externí odkaz: https://doaj.org/article/2209272f4f534aa0b0f07a3770ab3c50

CD8+ T Cells Protect During Vein Graft Disease Development

Autor: Karin H. Simons, Margreet R. de Vries, Hendrika A. B. Peters, J. Wouter Jukema, Paul H. A. Quax, Ramon Arens

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 6 (2019)

Aims: Vein grafts are frequently used conduits for arterial reconstruction in patients with cardiovascular disease. Unfortunately, vein graft disease (VGD) causes diminished patency rates. Innate immune system components are known to contribute to VG

Externí odkaz: https://doaj.org/article/2a8ada1a2d364c178466a359c5850df5

bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice

Autor: Paolo Lazzari, Karin H. Simons, H.A.B. Peters, Paul H.A. Quax, Thijs J. Sluiter, Laura Parma, Margreet R. de Vries

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, 10(1). NATURE RESEARCH
Sci Rep.

Intraplaque angiogenesis increases the chance of unstable atherosclerotic plaque rupture and thrombus formation leading to myocardial infarction. Basic Fibroblast Growth Factor (bFGF) plays a key role in angiogenesis and inflammation and is involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968e291d90cdb4930bd413d3f2f50453
https://doi.org/10.1038/s41598-020-72992-7

The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease

Autor: H.A.B. Peters, Paul H.A. Quax, M.R. de Vries, Johan Wouter Jukema, Jaap F. Hamming, Karin H. Simons

Publikováno v: Journal of Molecular and Cellular Cardiology, 121, 16-24

Background Venous grafts are commonly used as conduits to bypass occluded arteries. Unfortunately, patency rates are limited by vein graft disease (VGD). Toll like receptors (TLRs) can be activated in vein grafts by endogenous ligands. This study aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93262146c45ba3db0afc7732fe8963f7
https://hdl.handle.net/1887/94509

Vein graft failure:From pathophysiology to clinical outcomes

Autor: Margreet R. de Vries, Karin H. Simons, Paul H.A. Quax, J. Wouter Jukema, Jerry Braun

Publikováno v: De Vries, M R, Simons, K H, Jukema, J W, Braun, J & Quax, P H A 2016, ' Vein graft failure : From pathophysiology to clinical outcomes ', Nature Reviews Cardiology, vol. 13, no. 8, pp. 451-470 . https://doi.org/10.1038/nrcardio.2016.76
Nature Reviews Cardiology, 13(8), 451-470

Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside from balloon angioplasty, bypass graft surgery is the most commonly performed revascularization technique for occlusive arterial disease. Coronary artery bypass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9407889350df5050dd17310938748d40
https://research.vumc.nl/en/publications/893d9147-8dc6-4107-81ea-9fda22f07f01