Impact of Cytomegalovirus Infection and Genetic Background on the Frequencies of Peripheral Blood Suppressor Cells in Human Twins

Autor: David Goldeck, Lisbeth Aagaard Larsen, Kaare Christensen, Klaus Hamprecht, Lilly Öttinger, Karin Hähnel, Graham Pawelec

Publikováno v: Pathogens, Vol 10, Iss 8, p 963 (2021)

Frequencies and proportions of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in peripheral blood may be informative biomarkers for certain disease states. The influence of genetics and lifetime pathogen exposures on Treg and

Externí odkaz: https://doaj.org/article/45e9e06de78249f19918ae52dc56dc87

Impact of Cytomegalovirus Infection and Genetic Background on the Frequencies of Peripheral Blood Suppressor Cells in Human Twins

Autor: Lilly Öttinger, David Goldeck, Klaus Hamprecht, Graham Pawelec, Kaare Christensen, Karin Hähnel, Lisbeth Aagaard Larsen

Publikováno v: Pathogens, Vol 10, Iss 963, p 963 (2021)
Goldeck, D, Larsen, L A, Christensen, K, Hamprecht, K, Öttinger, L, Hähnel, K & Pawelec, G 2021, ' Impact of Cytomegalovirus Infection and Genetic Background on the Frequencies of Peripheral Blood Suppressor Cells in Human Twins ', Pathogens, vol. 10, no. 8, 963 . https://doi.org/10.3390/pathogens10080963
Pathogens
Volume 10
Issue 8

Frequencies and proportions of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in peripheral blood may be informative biomarkers for certain disease states. The influence of genetics and lifetime pathogen exposures on Treg and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04de79521fcd823aad960b98a90da61
https://www.mdpi.com/2076-0817/10/8/963

Cover Image, Volume 1466, Issue 1

Autor: Perihan Mir, Maksim Klimiankou, Betuel Findik, Karin Hähnel, Sabine Mellor‐Heineke, Cornelia Zeidler, Julia Skokowa, Karl Welte

Publikováno v: Annals of the New York Academy of Sciences. 1466

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eeb82afbc308f44590ca472355c52b1e
https://doi.org/10.1111/nyas.14360

CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival

Autor: Evelyna Derhovanessian, Karin Hähnel, Andrea B. Maier, Graham Pawelec, Helene Roelofs, Anton J. M. de Craen, Rudi G. J. Westendorp, Sai-Juan Chen

Publikováno v: The journals of gerontology. Series A : Biological sciences and medical sciences, 70(8), 917-23. Oxford University Press
Journal of Gerontology: Medical Sciences, 70(8), 917-923
Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 70(8), 917-923. Oxford University Press
Derhovanessian, E, Chen, S, Maier, A B, Hähnel, K, de Craen, A J M, Roelofs, H, Westendorp, R & Pawelec, G 2015, ' CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival ', The journals of gerontology. Series A : Biological sciences and medical sciences, vol. 70, no. 8, pp. 917-23 . https://doi.org/10.1093/gerona/glu128
Derhovanessian, E, Chen, S, Maier, A B, Hahnel, K, Craen, A J M, Roelofs, H, Westendorp, R & Pawelec, G 2015, ' CCR4(+) Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival ', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol. 70, no. 8, pp. 917-923 . https://doi.org/10.1093/gerona/glu128

CD4(+) regulatory T cells (Tregs) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens. Several studies have shown increased frequency and number of Tregs in the elderly. Whether such an increase has any

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab35a55b73660e461c194fb87383a702
https://doi.org/10.1093/gerona/glu128

Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

Autor: Anton J. M. de Craen, Rudi G. J. Westendorp, Karin Hähnel, Henning Zelba, Helene Roelofs, Eline Slagboom, Graham Pawelec, Evelyna Derhovanessian, Andrea B. Maier

Publikováno v: Age
Age, 35(4), 1387-1399. Springer Netherlands
AGE, 35(4), 1387-1399
Derhovanessian, E, Maier, A B, Hahnel, K, Zelba, H, De Craen, A J M, Roelofs, H, Slagboom, E P, Westendorp, R G J & Pawelec, G 2013, ' Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people ', Age, vol. 35, no. 4, pp. 1387-1399 . https://doi.org/10.1007/s11357-012-9425-7
AGE
AGE; Vol 35

The low percentages of naive T cells commonly observed in elderly people are thought to be causally associated with mortality, primarily from infectious disease, and are taken as a hallmark of “immunosenescence”. Whether low levels of naive cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b162425805aa3d7e88370a834948cb81
https://research.vu.nl/en/publications/d519ebed-c5b0-44c8-8040-3985b4c6a70b