Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Karin Forsberg-Nilsson"'
Autor:
Kelin Gonçalves de Oliveira, Anna Bång-Rudenstam, Sarah Beyer, Axel Boukredine, Hugo Talbot, Valeria Governa, Maria C. Johansson, Ann-Sofie Månsson, Karin Forsberg-Nilsson, Johan Bengzon, Johan Malmström, Charlotte Welinder, Mattias Belting
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Immunotherapies with antibody–drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceo
Externí odkaz:
https://doaj.org/article/2420e036341048829943fa3b910fe88d
Autor:
Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense, Sandrine Etienne-Manneville
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.
Externí odkaz:
https://doaj.org/article/3472ef5c78cc453cbe02531fd9522670
Autor:
Sharadha Sakthikumar, Ananya Roy, Lulu Haseeb, Mats E. Pettersson, Elisabeth Sundström, Voichita D. Marinescu, Kerstin Lindblad-Toh, Karin Forsberg-Nilsson
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Glioblastoma (GBM) has one of the worst 5-year survival rates of all cancers. While genomic studies of the disease have been performed, alterations in the non-coding regulatory regions of GBM have largely remained unexplored. We a
Externí odkaz:
https://doaj.org/article/bace325326104f708a9d8e09bc2fb81c
Autor:
Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, Cameron J. Herting, Ben Gabanic, José E. Velázquez Vega, Jennifer Shelton, Jeffrey M. Switchenko, James L. Ross, Leon F. McSwain, Jason T. Huse, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom, Naga Prathyusha Maturi, Patrick. J. Cimino, Eric C. Holland, Helmut Kettenmann, Cameron W. Brennan, Daniel J. Brat, Dolores Hambardzumyan
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subgroups to improve our understanding of pathogenetic mechanisms
Externí odkaz:
https://doaj.org/article/99915def14e347129ecc08b39b7bf014
Autor:
Anqi Xiong, Ananya Roy, Argyris Spyrou, Holger Weishaupt, Voichita D. Marinescu, Tommie Olofsson, Ola Hermanson, Fredrik J. Swartling, Karin Forsberg-Nilsson
Publikováno v:
Cancers, Vol 12, Iss 6, p 1483 (2020)
Pseudokinases, comprising 10% of the human kinome, are emerging as regulators of canonical kinases and their functions are starting to be defined. We previously identified the pseudokinase Nuclear Receptor Binding Protein 2 (NRBP2) in a screen for ge
Externí odkaz:
https://doaj.org/article/05e0bc4136f5456c924006684453626b
Autor:
Yuan Xie, Tobias Bergström, Yiwen Jiang, Patrik Johansson, Voichita Dana Marinescu, Nanna Lindberg, Anna Segerman, Grzegorz Wicher, Mia Niklasson, Sathishkumar Baskaran, Smitha Sreedharan, Isabelle Everlien, Marianne Kastemar, Annika Hermansson, Lioudmila Elfineh, Sylwia Libard, Eric Charles Holland, Göran Hesselager, Irina Alafuzoff, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom
Publikováno v:
EBioMedicine, Vol 2, Iss 10, Pp 1351-1363 (2015)
Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of r
Externí odkaz:
https://doaj.org/article/75556f6c5fd94fbea5d121e6ecd740bb
Autor:
Matilda Munksgaard Thorén, Katarzyna Chmielarska Masoumi, Cecilia Krona, Xiaoli Huang, Soumi Kundu, Linnéa Schmidt, Karin Forsberg-Nilsson, Marcus Floyd Keep, Elisabet Englund, Sven Nelander, Bo Holmqvist, Evy Lundgren-Åkerlund
Publikováno v:
Cancers, Vol 11, Iss 4, p 587 (2019)
New, effective treatment strategies for glioblastomas (GBMs), the most malignant and invasive brain tumors in adults, are highly needed. In this study, we investigated the potential of integrin α10β1 as a therapeutic target in GBMs. Expression leve
Externí odkaz:
https://doaj.org/article/7b822b5b52d24ad0ab8885ed08f11bc1
Autor:
Katarina Truvé, Peter Dickinson, Anqi Xiong, Daniel York, Kartika Jayashankar, Gerli Pielberg, Michele Koltookian, Eva Murén, Hans-Henrik Fuxelius, Holger Weishaupt, Fredrik J Swartling, Göran Andersson, Åke Hedhammar, Erik Bongcam-Rudloff, Karin Forsberg-Nilsson, Danika Bannasch, Kerstin Lindblad-Toh
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006000 (2016)
Gliomas are the most common form of malignant primary brain tumors in humans and second most common in dogs, occurring with similar frequencies in both species. Dogs are valuable spontaneous models of human complex diseases including cancers and may
Externí odkaz:
https://doaj.org/article/90d849f3102445cda97335abfc6d8330
Autor:
Shimei Wee, Maria Niklasson, Voichita Dana Marinescu, Anna Segerman, Linnéa Schmidt, Annika Hermansson, Peter Dirks, Karin Forsberg-Nilsson, Bengt Westermark, Lene Uhrbom, Sten Linnarsson, Sven Nelander, Michael Andäng
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115698 (2014)
Tumor-initiating cells are a subpopulation in aggressive cancers that exhibit traits shared with stem cells, including the ability to self-renew and differentiate, commonly referred to as stemness. In addition, such cells are resistant to chemo- and
Externí odkaz:
https://doaj.org/article/d40d7ec5b66645cea8c9dd221bf34140
Autor:
Di Yu, Chuan Jin, Mohanraj Ramachandran, Jing Xu, Berith Nilsson, Olle Korsgren, Katarina Le Blanc, Lene Uhrbom, Karin Forsberg-Nilsson, Bengt Westermark, Rachel Adamson, Norman Maitland, Xiaolong Fan, Magnus Essand
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54952 (2013)
Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for effi
Externí odkaz:
https://doaj.org/article/81845b54f6f045ed86a4443cbfdc2970