Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

Autor: Wei-Chun Au, Tianyi Zhang, Prashant K Mishra, Jessica R Eisenstatt, Robert L Walker, Josefina Ocampo, Anthony Dawson, Jack Warren, Michael Costanzo, Anastasia Baryshnikova, Karin Flick, David J Clark, Paul S Meltzer, Richard E Baker, Chad Myers, Charles Boone, Peter Kaiser, Munira A Basrai

Publikováno v: PLoS Genetics, Vol 16, Iss 2, p e1008597 (2020)

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cell

Externí odkaz: https://doaj.org/article/4a4e4d4931964e2b9c6fa1e904c0dd0e

Cdc48/Shp1 participates in dissociation of protein complexes to regulate their activity

Autor: Peter K. Kaiser, Linda Lauinger, Karin Flick

Publikováno v: Current Genetics. 67:263-265

The AAA-ATPase p97/Cdc48 is one of the most abundant proteins in eukaryotes, and owing to its multiple functions, is considered the swiss army knife of cells. Recent findings demonstrate that p97/Cdc48 and its cofactor p47/Shp1 control the heavy meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885143b1f32fc81cb618a86bc5003c16
https://doi.org/10.1007/s00294-020-01136-1

Cdc48 cofactor Shp1 regulates signal-induced SCF

Autor: Linda, Lauinger, Karin, Flick, James L, Yen, Radhika, Mathur, Peter, Kaiser

Publikováno v: Proc Natl Acad Sci U S A

Organisms can adapt to a broad spectrum of sudden and dramatic changes in their environment. These abrupt changes are often perceived as stress and trigger responses that facilitate survival and eventual adaptation. The ubiquitin–proteasome system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c138b937d1a5dbc3175f8aedd8c343c9
https://pubmed.ncbi.nlm.nih.gov/32817489

Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast

Autor: Chad L. Myers, Paul S. Meltzer, Munira A. Basrai, Michael Costanzo, Jessica R. Eisenstatt, Anastasia Baryshnikova, Charles Boone, Jack Warren, Tianyi Zhang, Richard Baker, Wei Chun Au, David Clark, Robert L. Walker, Josefina Ocampo, Peter K. Kaiser, Karin Flick, Anthony R. Dawson, Prashant K. Mishra

Publikováno v: PLoS Genetics, Vol 16, Iss 2, p e1008597 (2020)
PLoS genetics, vol 16, iss 2
PLoS Genetics
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227a03b20d02fb24ea8e224fc4102e64
https://doi.org/10.1371/journal.pgen.1008597

Protein degradation and the stress response

Autor: Karin Flick, Peter K. Kaiser

Publikováno v: Seminars in Cell & Developmental Biology. 23:515-522

Environmental stresses are manifold and so are the responses they elicit. This is particularly true for higher eukaryotes where various tissues and cell types are differentially affected by the insult. Type and scope of the stress response can theref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8376742cfcdf2459a295f7047f294b71
https://doi.org/10.1016/j.semcdb.2012.01.019