Cadmium binding by the F-box domain induces p97-mediated SCF complex disassembly to activate stress response programs

Autor: Linda Lauinger, Anna Andronicos, Karin Flick, Clinton Yu, Geetha Durairaj, Lan Huang, Peter Kaiser

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract The F-box domain is a highly conserved structural motif that defines the largest class of ubiquitin ligases, Skp1/Cullin1/F-box protein (SCF) complexes. The only known function of the F-box motif is to form the protein interaction surface wi

Externí odkaz: https://doaj.org/article/9b7fde7eb95948aa9c256e4f21d10877

Cdc48 cofactor Shp1 regulates signal-induced SCF Met30 disassembly

Autor: Peter K. Kaiser, James L. Yen, Linda Lauinger, Radhika Mathur, Karin Flick

Publikováno v: Proceedings of the National Academy of Sciences. 117:21319-21327

Organisms can adapt to a broad spectrum of sudden and dramatic changes in their environment. These abrupt changes are often perceived as stress and trigger responses that facilitate survival and eventual adaptation. The ubiquitin-proteasome system (U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91e0aefde338fb3661577d6d52ebdef6
https://doi.org/10.1073/pnas.1922891117

Cdc48 cofactor Shp1 regulates signal-induced SCFMet30 disassembly

Autor: Linda Lauinger, James L. Yen, Radhika Mathur, Karin Flick, Peter K. Kaiser

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 35

Organisms can adapt to a broad spectrum of sudden and dramatic changes in their environment. These abrupt changes are often perceived as stress and trigger responses that facilitate survival and eventual adaptation. The ubiquitin proteasome system (U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15215f4854313fa88850096e7f209b6b
https://escholarship.org/uc/item/29f845pq

Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast

Autor: Chad L. Myers, Paul S. Meltzer, Munira A. Basrai, Michael Costanzo, Jessica R. Eisenstatt, Anastasia Baryshnikova, Charles Boone, Jack Warren, Tianyi Zhang, Richard Baker, Wei Chun Au, David Clark, Robert L. Walker, Josefina Ocampo, Peter K. Kaiser, Karin Flick, Anthony R. Dawson, Prashant K. Mishra

Publikováno v: PLoS Genetics, Vol 16, Iss 2, p e1008597 (2020)
PLoS genetics, vol 16, iss 2
PLoS Genetics
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227a03b20d02fb24ea8e224fc4102e64
https://doi.org/10.1371/journal.pgen.1008597

Protein degradation and the stress response

Autor: Karin Flick, Peter K. Kaiser

Publikováno v: Seminars in Cell & Developmental Biology. 23:515-522

Environmental stresses are manifold and so are the responses they elicit. This is particularly true for higher eukaryotes where various tissues and cell types are differentially affected by the insult. Type and scope of the stress response can theref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8376742cfcdf2459a295f7047f294b71
https://doi.org/10.1016/j.semcdb.2012.01.019