Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Karin Endrizzi"'
Autor:
Karin Endrizzi, Thomas E. Mürdter, Andreas K. Nussler, Renzo Wolbold, Ulrich M. Zanger, Kathrin Klein, Thomas Lang, Niels Krebsfaenger, Peter Neuhaus, Janet K. Coller, Michel Eichelbaum
Publikováno v:
British Journal of Clinical Pharmacology. 54:157-167
Aims To investigate in a large panel of 50 human liver samples the contribution of CYP2C9, CYP2D6, and CYP3A4 to the overall formation of the potent antioestrogen Z-4-hydroxy-tamoxifen, and how various genotypes affect its formation from tamoxifen. M
Publikováno v:
The Plant Journal. 10:967-979
The function of the SHOOT MERISTEMLESS (STM) gene in shoot and floral meristems throughout Arabidopsis development has been analyzed. The results show that STM plays a major role in maintaining shoot and floral meristems. In an allelic series of stm
Autor:
Joachim Fischer, Kathrin Klein, Michel Eichelbaum, Ulrich M. Zanger, Karin Endrizzi, Peter Neuhaus, Matthias Schwab, Andreas K. Nussler
Publikováno v:
Analytical biochemistry. 300(2)
The human drug oxidizing cytochrome P450, CYP2D6, is expressed at highly variable levels mainly due to a common genetic polymorphism which leads to the poor metabolizer phenotype in carriers of two nonfunctional alleles and to the extensive metaboliz