Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karin Ehrenreiter"'
Autor:
Harina Vin, Sandra S Ojeda, Grace Ching, Marco L Leung, Vida Chitsazzadeh, David W Dwyer, Charles H Adelmann, Monica Restrepo, Kristen N Richards, Larissa R Stewart, Lili Du, Scarlett B Ferguson, Deepavali Chakravarti, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L Curry, Kevin B Kim, Ana M Ciurea, Madeleine Duvic, Victor G Prieto, Stephen E Ullrich, Kevin N Dalby, Elsa R Flores, Kenneth Y Tsai
Publikováno v:
eLife, Vol 2 (2013)
Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cu
Externí odkaz:
https://doaj.org/article/b82986af3d064ca596c82909e620f375
Autor:
Kenneth Y. Tsai, Nizar M. Tannir, Naifa L. Busaidy, Madeleine Duvic, Ana M. Ciurea, Jonathan L. Curry, Rosamaria Ruggieri, Manuela Baccarini, Karin Ehrenreiter, Haiching Ma, David W. Dwyer, Vida Chitsazzadeh, Charles H. Adelmann, Sandra S. Ojeda, Grace Ching, Harina Vin
PDF - 69KB, In-vitro kinase assays were performed against sorafenib with a staurosporine positive control across a concentration range of 0.5 nM to 10 μM). Blank values are those for which no significant inhibition occurred over the entire concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88de25d705152f0908a5d78921600fc
https://doi.org/10.1158/1535-7163.22503256.v1
https://doi.org/10.1158/1535-7163.22503256.v1
Autor:
Kenneth Y. Tsai, Nizar M. Tannir, Naifa L. Busaidy, Madeleine Duvic, Ana M. Ciurea, Jonathan L. Curry, Rosamaria Ruggieri, Manuela Baccarini, Karin Ehrenreiter, Haiching Ma, David W. Dwyer, Vida Chitsazzadeh, Charles H. Adelmann, Sandra S. Ojeda, Grace Ching, Harina Vin
PDF - 1060KB, Sorafenib suppresses JNK-dependent apoptosis as assessed by cleaved caspase 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f52bce56824158bd5240f1f3eaebe33
https://doi.org/10.1158/1535-7163.22503259
https://doi.org/10.1158/1535-7163.22503259
Autor:
Rainer Ettelt, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini
Lysosomes are highly dynamic organelles that regulate metabolic signaling pathways by recruiting cytosolic molecules to protein platforms on the lysosomal membrane. We performed a proximity-dependent labeling screen to identify novel proteins recruit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fc1426bafa24ed62c05d106004752ac
https://doi.org/10.1101/2023.02.01.526449
https://doi.org/10.1101/2023.02.01.526449
Autor:
Karina Kramer, Eszter Doma, Coralie Dorard, Sabine Fürlinger, Barbara Maier, Karin Ehrenreiter, Manuela Baccarini, Andrea Varga, Botond Cseh, Reiner Wimmer, Tatjana Hirschmugl
Publikováno v:
The Febs Journal
The endothelium functions as a semipermeable barrier regulating fluid homeostasis, nutrient, and gas supply to the tissue. Endothelial permeability is increased in several pathological conditions including inflammation and tumors; despite its clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18799024995d587eb40f07f86764693e
https://pubmed.ncbi.nlm.nih.gov/31081213
https://pubmed.ncbi.nlm.nih.gov/31081213
Autor:
Bertram Aschenbrenner, Pawel Kocieniewski, Manuela Baccarini, Tomasz Lipniacki, Marek Kochańczyk, Karin Ehrenreiter, Andrea Varga
Publikováno v:
Science Signaling. 10
Downstream of growth factor receptors and of the guanine triphosphatase (GTPase) RAS, heterodimers of the serine/threonine kinases BRAF and RAF1 are critical upstream kinases and activators of the mitogen-activated protein kinase (MAPK) module contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290e6723cde38cf69633b26da05708ca
https://doi.org/10.1126/scisignal.aai8482
https://doi.org/10.1126/scisignal.aai8482
Autor:
Yoko Nakazawa, Lingchun Zeng, Elena Bevilacqua, Florian Kern, Manuela Baccarini, Karin Ehrenreiter, Marsha Rich Rosner, Akira Imamoto, Jyotsana Menon, Ray Menard
Publikováno v:
Cellular Signalling. 25:1156-1165
MAP kinase (MAPK) signaling results from activation of Raf kinases in response to external or internal stimuli. Here, we demonstrate that Raf Kinase Inhibitory Protein (RKIP) regulates the activation of MAPK when B-Raf signaling is defective. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fa4a73be3a21b179a1f04f78c43186
https://doi.org/10.1016/j.cellsig.2013.02.005
https://doi.org/10.1016/j.cellsig.2013.02.005
Autor:
Herbert Pfister, Florian Kern, Marisa Gariglio, Santo Landolfo, Manuela Baccarini, Gian Paolo Marcuzzi, Sigrun Smola, Marco De Andrea, Cinzia Borgogna, Manuela M. Landini, Michele Mondini, Karin Ehrenreiter, Massimo Rittà
Publikováno v:
Cancer Research. 70:7938-7948
Human papillomaviruses (HPV) of the genus β are thought to play a role in human skin cancers, but this has been difficult to establish using epidemiologic approaches. To gain insight into the transforming activities of β-HPV, transgenic mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e121d0f7e30c4045f1168b004bf27392
https://doi.org/10.1158/0008-5472.can-10-1128
https://doi.org/10.1158/0008-5472.can-10-1128
Autor:
Vanishree Velamoor, Gergana Galabova-Kovacs, Florian Kern, Karin Ehrenreiter, Manuela Baccarini, Maria Sibilia, Katrin Meissl
Publikováno v:
Cancer Cell. 16:149-160
Ras activation is common to many human cancers and promotes cell proliferation and survival by initiating multiple signaling cascades. Accordingly, Ras-transformed cells are generally considered too resourceful to become addicted to a single effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e14251b9b3ae2ef9ab6cc78c822bef
https://doi.org/10.1016/j.ccr.2009.06.008
https://doi.org/10.1016/j.ccr.2009.06.008