Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Karin Effertz"'
Autor:
David J. Segal, Carlos F. Barbas, Maja B. Gere, Eva Guhl, Karin Effertz, Stephen Alwin, Matthew D. Weitzman, Toni Cathomen
Publikováno v:
Molecular Therapy. 12:610-617
Genome engineering through homologous recombination (HR) is a powerful instrument for studying biological pathways or creating treatment options for genetic disorders. In mammalian cells HR is rare but the creation of targeted DNA double-strand break
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e6ee1d12c1a87bb9888e19fa203e52
https://doi.org/10.1016/j.ymthe.2005.06.094
https://doi.org/10.1016/j.ymthe.2005.06.094
Publikováno v:
European Journal of Biochemistry. 267:3301-3308
N-Acetylglucosamine is produced by the endogenous degradation of glycoconjugates and by the degradation of dietary glycoconjugates by glycosidases. It enters the pathways of aminosugar metabolism by the action of N-acetylglucosamine kinase. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cedd7e9a92a1258dd26cccb959403c0e
https://doi.org/10.1046/j.1432-1327.2000.01360.x
https://doi.org/10.1046/j.1432-1327.2000.01360.x
Publikováno v:
Journal of Biological Chemistry. 274:28771-28778
N-Acetylneuraminic acid is the most common naturally occurring sialic acid, as well as being the biosynthetic precursor of this group of compounds. UDP-GlcNAc 2-epimerase/N-acetylmannosamine kinase has been shown to be the key enzyme of N-acetylneura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2c23391ca9a131a2a19fd02c3de2b1
https://doi.org/10.1074/jbc.274.40.28771
https://doi.org/10.1074/jbc.274.40.28771
Autor:
Lothar Lucka, Christoph Weise, Stephan Hinderlich, Werner Reutter, Roger Stäsche, Petra Moormann, Karin Effertz
Publikováno v:
Journal of Biological Chemistry. 272:24319-24324
N-Acetylneuraminic acid (Neu5Ac) is the precursor of sialic acids, a group of important molecules in biological recognition systems. Biosynthesis of Neu5Ac is initiated and regulated by its key enzyme, UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f0f60a9454884ce70b77f35e02faf3
https://doi.org/10.1074/jbc.272.39.24319
https://doi.org/10.1074/jbc.272.39.24319
Autor:
Luca Meoli, Christiane Otto, Markus Irgang, Valeria Zazzu, Martin Hrabé de Angelis, Thure Adler, Valerie Gailus-Durner, Dirk H. Busch, Dian Soewarto, Karin Effertz, Christoph S. Nabzdyk, Patricia Ruiz Noppinger, Jörg Isensee, Helmut Fuchs, Henning Witt
Publikováno v:
Endocrinology 150, 1722-1730 (2009)
Multiple reports implicated the function of G protein-coupled receptor (GPR)-30 with nongenomic effects of estrogen, suggesting that GPR30 might be a G-protein coupled estrogen receptor. However, the findings are controversial and the expression patt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2692af663d2a86e0e092305a7d42fe72
https://pubmed.ncbi.nlm.nih.gov/19307418
https://pubmed.ncbi.nlm.nih.gov/19307418
Autor:
Mario Menk, Jan H. Schefe, Karin Effertz, Patricia Ruiz, Pier Paolo Pandolfi, Jana Reinemund, Heiko Funke-Kaiser, Robin M. Hobbs, Thomas Unger
Publikováno v:
Circulation research. 99(12)
A human renin/prorenin receptor (RER) has recently been cloned. To gain insight into the molecular function of the RER, we studied its signal transduction mechanisms. Initially, we found a ubiquitous and intracellular expression pattern of the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431e4366d25812b27ff5fbfe97cead7b
https://pubmed.ncbi.nlm.nih.gov/17158342
https://pubmed.ncbi.nlm.nih.gov/17158342
Autor:
Beate Koksch, Karin Effertz, Roger R. Beerli, Pilar Blancafort, Adrian Huber, David J. Segal, Caren V. Lund, Carlos F. Barbas, Birgit Dreier, Laurent Magnenat, David L. Valente
Publikováno v:
Biochemistry. 42(7)
In previous studies, we have developed a technology for the rapid construction of novel DNA-binding proteins with the potential to recognize any unique site in a given genome. This technology relies on the modular assembly of modified zinc finger DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc1e696d5fa081f6bed9448d573f2fb
https://pubmed.ncbi.nlm.nih.gov/12590603
https://pubmed.ncbi.nlm.nih.gov/12590603
Autor:
Karin Effertz, Toni Cathomen, Maja B. Gere, Matthew D. Weitzman, David J. Segal, Stephen Alwin, Eva Guhl, Carlos F. Barbas
Publikováno v:
Molecular Therapy. 11:S144-S145
Genome engineering is a powerful instrument to study basic biological questions or to create treatment options for genetic diseases. A safe way to correct genetic mutations is through homologous recombination (HR), during which a mutant sequence is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b205fc7c03e1ca8c75d7c4ea0284976
https://doi.org/10.1016/j.ymthe.2005.06.374
https://doi.org/10.1016/j.ymthe.2005.06.374
Autor:
Werner Reutter, Kerstin Danker, Lothar Lucka, Karin Effertz, Rüdiger Horstkorte, Sabine Nöhring
Publikováno v:
FEBS Letters. (3):315-318
UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (UDP-GlcNAc 2-epimerase) is the key enzyme in the de novo synthesis pathway of neuraminic acid, which is widely expressed as a terminal carbohydrate residue on glycoconjugates. UDP-GlcNAc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9a46b3321286003d6e92fa2261f6b2