Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Karin E Bornfeldt"'
Autor:
Ida Rune, Bidda Rolin, Christian Larsen, Dennis Sandris Nielsen, Jenny E Kanter, Karin E Bornfeldt, Jens Lykkesfeldt, Karsten Buschard, Rikke Kaae Kirk, Berit Christoffersen, Johannes Josef Fels, Knud Josefsen, Pernille Kihl, Axel Kornerup Hansen
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146439 (2016)
The importance of the gut microbiota (GM) in disease development has recently received increased attention, and numerous approaches have been made to better understand this important interplay. For example, metabolites derived from the GM have been s
Externí odkaz:
https://doaj.org/article/7e260d4bc6914d3d9feefa4dad2a5b9d
Autor:
Sara N Vallerie, Farah Kramer, Shelley Barnhart, Jenny E Kanter, Richard M Breyer, Katrin I Andreasson, Karin E Bornfeldt
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158316 (2016)
Type 1 diabetes mellitus (T1DM) is associated with cardiovascular complications induced by atherosclerosis. Prostaglandin E2 (PGE2) is often raised in states of inflammation, including diabetes, and regulates inflammatory processes. In myeloid cells,
Externí odkaz:
https://doaj.org/article/8b40cda0075c41e995fa4c018d2e4c8b
Autor:
Florian Willecke, Chujun Yuan, Kazuhiro Oka, Lawrence Chan, Yunying Hu, Shelley Barnhart, Karin E Bornfeldt, Ira J Goldberg, Edward A Fisher
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128996 (2015)
We tested whether a high fat diet (HFD) containing the inflammatory dietary fatty acid palmitate or insulin deficient diabetes altered the remodeling of atherosclerotic plaques in LDL receptor knockout (Ldlr-/-) mice. Cholesterol reduction was achiev
Externí odkaz:
https://doaj.org/article/01c17747e69b490eb9c42001f68854a7
Autor:
Tina Costacou, Tomas Vaisar, Rachel G. Miller, W. Sean Davidson, Jay W. Heinecke, Trevor J. Orchard, Karin E. Bornfeldt
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background The cholesterol efflux capacity of high density lipoprotein (HDL) is negatively associated with cardiovascular risk. Small HDL particles account almost quantitatively for cholesterol efflux capacity, perhaps mediated through efflux of chol
Externí odkaz:
https://doaj.org/article/e3cae4dfe20347dd9e9e0576903478a1
Autor:
Lev Becker, Ning-Chun Liu, Michelle M Averill, Wei Yuan, Nathalie Pamir, Yufeng Peng, Angela D Irwin, Xiaoyun Fu, Karin E Bornfeldt, Jay W Heinecke
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33297 (2012)
Monocytes differentiate into heterogeneous populations of tissue macrophages and dendritic cells (DCs) that regulate inflammation and immunity. Identifying specific populations of myeloid cells in vivo is problematic, however, because only a limited
Externí odkaz:
https://doaj.org/article/04a156f1c44b4ec6bf9348913949b4b1
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002645 (2012)
Mammalian nuclear receptors broadly influence metabolic fitness and serve as popular targets for developing drugs to treat cardiovascular disease, obesity, and diabetes. However, the molecular mechanisms and regulatory pathways that govern lipid meta
Externí odkaz:
https://doaj.org/article/16cc79d89230404eabfc54417e730cbb
Autor:
Hongkui Zeng, Kyoji Horie, Linda Madisen, Maria N Pavlova, Galina Gragerova, Alex D Rohde, Brian A Schimpf, Yuqiong Liang, Ethan Ojala, Farah Kramer, Patricia Roth, Olga Slobodskaya, Io Dolka, Eileen A Southon, Lino Tessarollo, Karin E Bornfeldt, Alexander Gragerov, George N Pavlakis, George A Gaitanaris
Publikováno v:
PLoS Genetics, Vol 4, Iss 5, p e1000069 (2008)
Inducible and reversible regulation of gene expression is a powerful approach for uncovering gene function. We have established a general method to efficiently produce reversible and inducible gene knockout and rescue in mice. In this system, which w
Externí odkaz:
https://doaj.org/article/d20796b8c63140f2a6de21e85453e4cc
Autor:
Baohai Shao, Masami Shimizu-Albergine, Farah Kramer, Jenny E. Kanter, Jay W. Heinecke, Tomas Vaisar, Bettina Mittendorfer, Bruce W. Patterson, Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 4, Pp 100531- (2024)
Altered apolipoprotein kinetics play a critical role in promoting dyslipidemia and atherogenesis. Human apolipoprotein kinetics have been extensively evaluated, but similar studies in mice are hampered by the lack of robust methods suitable for the s
Externí odkaz:
https://doaj.org/article/eb7bb67902ae41f8935f1f4dd33cf409
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100505- (2024)
Externí odkaz:
https://doaj.org/article/7678c49009144579b529f9dcff0f32fc
Autor:
Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 1, Pp 100475- (2024)
Increased circulating levels of apolipoprotein C3 (APOC3) predict cardiovascular disease (CVD) risk in humans, and APOC3 promotes atherosclerosis in mouse models. APOC3’s mechanism of action is due in large part to its ability to slow the clearance
Externí odkaz:
https://doaj.org/article/4543683428a14a1ea968c41c29c614c6