Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Karin E Bornfeldt"'
Autor:
Tina Costacou, Tomas Vaisar, Rachel G. Miller, W. Sean Davidson, Jay W. Heinecke, Trevor J. Orchard, Karin E. Bornfeldt
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background The cholesterol efflux capacity of high density lipoprotein (HDL) is negatively associated with cardiovascular risk. Small HDL particles account almost quantitatively for cholesterol efflux capacity, perhaps mediated through efflux of chol
Externí odkaz:
https://doaj.org/article/e3cae4dfe20347dd9e9e0576903478a1
Autor:
Baohai Shao, Masami Shimizu-Albergine, Farah Kramer, Jenny E. Kanter, Jay W. Heinecke, Tomas Vaisar, Bettina Mittendorfer, Bruce W. Patterson, Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 4, Pp 100531- (2024)
Altered apolipoprotein kinetics play a critical role in promoting dyslipidemia and atherogenesis. Human apolipoprotein kinetics have been extensively evaluated, but similar studies in mice are hampered by the lack of robust methods suitable for the s
Externí odkaz:
https://doaj.org/article/eb7bb67902ae41f8935f1f4dd33cf409
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100505- (2024)
Externí odkaz:
https://doaj.org/article/7678c49009144579b529f9dcff0f32fc
Autor:
Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 1, Pp 100475- (2024)
Increased circulating levels of apolipoprotein C3 (APOC3) predict cardiovascular disease (CVD) risk in humans, and APOC3 promotes atherosclerosis in mouse models. APOC3’s mechanism of action is due in large part to its ability to slow the clearance
Externí odkaz:
https://doaj.org/article/4543683428a14a1ea968c41c29c614c6
Autor:
Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100383- (2023)
Externí odkaz:
https://doaj.org/article/0a99aab8f0a043ce9aa2d01e6388b069
Autor:
Baohai Shao, Farsad Afshinnia, Anna V. Mathew, Graziella E. Ronsein, Carissa Thornock, Angela D. Irwin, Mayank Kansal, Panduranga S. Rao, Mirela Dobre, Sadeer Al-Kindi, Matthew R. Weir, Alan Go, Jiang He, Jing Chen, Harold Feldman, Karin E. Bornfeldt, Subramaniam Pennathur, Matthias Kretzler, Debbie Gipson, Markus Bitzer, Crystal Gadegbeku, Keith Bellovich, Zeenat Bhat, Susan Massengill, Kalyani Perumal, Lawrence J. Appel, Debbie L. Cohen, James P. Lash, Robert G. Nelson, Mahboob Rahman, Vallabh O. Shah, Mark L. Unruh
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100381- (2023)
Patients with chronic kidney disease (CKD) are at high risk for CVD. However, traditional CVD risk factors cannot completely explain the increased risk. Altered HDL proteome is linked with incident CVD in CKD patients, but it is unclear whether other
Externí odkaz:
https://doaj.org/article/51bb7f209b9345f2821df3f6e9b94938
Pulmonary surfactant protein B carried by HDL predicts incident CVD in patients with type 1 diabetes
Autor:
Baohai Shao, Janet K. Snell-Bergeon, Laura L. Pyle, Katie E. Thomas, Ian H. de Boer, Vishal Kothari, Jere Segrest, William S. Davidson, Karin E. Bornfeldt, Jay W. Heinecke
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100196- (2022)
Atherosclerotic CVD is the major cause of death in patients with type 1 diabetes mellitus (T1DM). Alterations in the HDL proteome have been shown to associate with prevalent CVD in T1DM. We therefore sought to determine which proteins carried by HDL
Externí odkaz:
https://doaj.org/article/02a720eab7624a9ab69fbaae8aea3b24
Autor:
Diego Gomes, Shari Wang, Leela Goodspeed, Katherine E. Turk, Tomasz Wietecha, Yongjun Liu, Karin E. Bornfeldt, Kevin D. O'Brien, Alan Chait, Laura J. den Hartigh
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100174- (2022)
Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and co
Externí odkaz:
https://doaj.org/article/8ffc4aeca8934757a42ccde986d1a313
Autor:
Shimpi Bedi, Jamie Morris, Amy Shah, Rachel C. Hart, W. Gray Jerome, Stephen G. Aller, Chongren Tang, Tomas Vaisar, Karin E. Bornfeldt, Jere P. Segrest, Jay W. Heinecke, W. Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100168- (2022)
Because of its critical role in HDL formation, significant efforts have been devoted to studying apolipoprotein A-I (APOA1) structural transitions in response to lipid binding. To assess the requirements for the conformational freedom of its termini
Externí odkaz:
https://doaj.org/article/85e2394e2ac54dddbe32143770942ea7
Autor:
Hye Seung Jung, Masami Shimizu-Albergine, Xia Shen, Farah Kramer, Dan Shao, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Rong Tian, Jenny E. Kanter, Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 33-44 (2020)
Chronic inflammation contributes to cardiovascular disease. Increased levels of the inflammatory cytokine, TNF-α, are often present in conditions associated with cardiovascular disease risk, and TNF-α induces a number of pro-atherogenic effects in
Externí odkaz:
https://doaj.org/article/7680d29b12544a35b2fbd65148406143