Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Karin Diggle"'
Autor:
Hyun Young Kim, Wonseok Lee, Xiao Liu, Haeum Jang, Sadatsugu Sakane, Raquel Carvalho-Gontijo Weber, Karin Diggle, Samuel A. Kerk, Christian M. Metallo, Tatiana Kisseleva, David A. Brenner
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103111- (2024)
Summary: Currently, there is no effective treatment for obesity and alcohol-associated liver diseases, partially due to the lack of translational human models. Here, we present a protocol to generate 3D human liver spheroids that contain all the live
Externí odkaz:
https://doaj.org/article/4d3e50db289e472d86f78e55cfae2e45
Autor:
Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor, Raquel Carvalho Gontijo Weber, Wonseok Lee, Xiao Liu, Kevin Lam, Kei Ishizuka, Sara Brin Rosenthal, Karin Diggle, David A. Brenner, Tatiana Kisseleva
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 93-106 (2024)
Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is c
Externí odkaz:
https://doaj.org/article/0f9a90d94d5e4bd0a2e4ea88044b0319
Autor:
Natalia A. Osna, Irina Tikhanovich, Martí Ortega-Ribera, Sebastian Mueller, Chaowen Zheng, Johannes Mueller, Siyuan Li, Sadatsugu Sakane, Raquel Carvalho Gontijo Weber, Hyun Young Kim, Wonseok Lee, Souradipta Ganguly, Yusuke Kimura, Xiao Liu, Debanjan Dhar, Karin Diggle, David A. Brenner, Tatiana Kisseleva, Neha Attal, Iain H. McKillop, Shilpa Chokshi, Ram Mahato, Karuna Rasineni, Gyongyi Szabo, Kusum K. Kharbanda
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 404 (2024)
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Mult
Externí odkaz:
https://doaj.org/article/142e2cdd280940af8c937a0c17615d54
Autor:
Xiao Liu, Kevin Lam, Huayi Zhao, Sadatsugu Sakane, Hyun Young Kim, Alvaro Eguileor, Karin Diggle, Shuai Wu, Raquel Carvalho Gontijo Weber, Pejman Soroosh, Mojgan Hosseini, Kristin Mekeel, David A. Brenner, Tatiana Kisseleva
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102391- (2023)
Summary: Here, we present a protocol for isolating human hepatocytes and neural progenitor cells from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for scaled-up liver cell isolation and optimization of chemical dige
Externí odkaz:
https://doaj.org/article/06a0220e8c7f4637ab4455a2add3b85d
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3280 (2023)
Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they are implicated in several serio
Externí odkaz:
https://doaj.org/article/20b433858dca49e4989ff7d29063ace9
Autor:
Xiao Liu, Sara Brin Rosenthal, Nairika Meshgin, Jacopo Baglieri, Sami G. Musallam, Karin Diggle, Kevin Lam, Raymond Wu, Stephanie Q. Pan, Yibu Chen, Ken Dorko, Sharon Presnell, Chris Benner, Mojgan Hosseini, Hidekazu Tsukamoto, David Brenner, Tatiana Kisseleva
Publikováno v:
Hepatology Communications, Vol 4, Iss 4, Pp 606-626 (2020)
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar. Hepatic stellate cells (HSCs) are the major source of
Externí odkaz:
https://doaj.org/article/1a716209002d475599954c71be02bd75
Autor:
Ken Dorko, Hidekazu Tsukamoto, Tatiana Kisseleva, Jacopo Baglieri, Nairika Meshgin, Stephanie Q. Pan, Christopher Benner, Sharon Presnell, Karin Diggle, Yibu Chen, Kevin Lam, David A. Brenner, Xiao Liu, Raymond Wu, Sara Brin Rosenthal, Sami G. Musallam, Mojgan Hosseini
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 4, Iss 4, Pp 606-626 (2020)
Hepatology Communications, Vol 4, Iss 4, Pp 606-626 (2020)
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar. Hepatic stellate cells (HSCs) are the major source of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d0e7f21db18bb74e3e228d216e9e9a
http://europepmc.org/articles/PMC7109347
http://europepmc.org/articles/PMC7109347
Autor:
Tatiana Kisseleva, Karin Diggle, Timothy V. Pham, Pablo Tamayo, Dan S. Kaufman, Andrea Fanjul, Hamidreza Hashemi, Luisjesus S. Cruz, Manuel Fierro, Somayeh Pouyanfard, Nairika Meshgin
Publikováno v:
Stem cells (Dayton, Ohio), vol 39, iss 12
With an increasing number of patients with degenerative hepatic diseases, such as liver fibrosis, and a limited supply of donor organs, there is an unmet need for therapies that can repair or regenerate damaged liver tissue. Treatment with macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adbf0f7354e0a49da84c1ad426c654c
https://pubmed.ncbi.nlm.nih.gov/34460131
https://pubmed.ncbi.nlm.nih.gov/34460131
Autor:
Tatiana Kisseleva, Min Cong, Chunyan Jiang, Karin Diggle, David A. Brenner, Tarek Hassanein, Keiko Iwaisako
Publikováno v:
Archives of clinical and biomedical research
Aim: To investigate the therapeutic effect of FZHY on hepatic fibrosis in mice and to determine the mechanism of its action. Methods: Wild type mice were subjected to toxic (carbon tetrachloride, CCl4) or cholestatic (bile duct ligation, BDL). Upon i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e975e61027bdb202ad7de8fffae2f6
https://pubmed.ncbi.nlm.nih.gov/33210080
https://pubmed.ncbi.nlm.nih.gov/33210080
Autor:
Xiao Liu, Takahiro Nishio, Kevin Lam, Jacopo Baglieri, Rolando Arreola, Karin Diggle, Sara Brin Rosenthal, David A. Brenner, Nairika Meshgin, Tatiana Kisseleva
Publikováno v:
Gastroenterology. 158:S-1277
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a22de5c40675c0005a74416320a6c95
https://doi.org/10.1016/s0016-5085(20)33853-1
https://doi.org/10.1016/s0016-5085(20)33853-1