HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial

Autor: Nienke E van Trommel, Gemma G Kenter, John Haanen, Tanja D de Gruijl, Sanne Samuels, Ekaterina S Jordanova, Ton Schumacher, Joost H van den Berg, Bastiaan Nuijen, Jos Beijnen, Marc van Beurden, Noor Alida Maria Bakker, Jossie Rotman, Henry J MAA Zijlmans, Maartje van Ruiten, Karin De Visser

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)

Background Usual vulvar intraepithelial neoplasia (uVIN) is a premalignancy caused by persistent infection with high-risk types of human papillomavirus (HPV), mainly type 16. Even though different treatment modalities are available (eg, surgical exci

Externí odkaz: https://doaj.org/article/c29336b4129f4a6a8b7b92a61e5b1b59

Data from CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis

Autor: Jukka Westermarck, Goutham Narla, Karin de Visser, Emilia Peuhu, Heikki Joensuu, Rene H. Medema, Krister Wennerberg, Jochen Maurer, Laura L. Elo, Pauliina Kronqvist, Denise C. Connolly, Karolina Pavic, Xi Qiao, Harri Sihto, Sofia Khan, Prson Gautam, Tove J. Grönroos, Femke M. Feringa, Julia P. Vainonen, Anna N. Cvrljevic, Umar Butt, Caroline Farrington, Srikar G. Nagelli, Anni Laine

Basal-like breast cancers (BLBC) are characterized by defects in homologous recombination (HR), deficient mitotic checkpoint, and high-proliferation activity. Here, we discover CIP2A as a candidate driver of BLBC. CIP2A was essential for DNA damage�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58953009a86d62cede066667426b4c40
https://doi.org/10.1158/0008-5472.c.6513027

Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk

Autor: Mathilde Matthea Machteld Almekinders, Edwin Roger Parra, Tapsi Kumar, Karin De Visser, Tycho Bismeijer, Baohua Sun

Publikováno v: British Journal of Cancer, 127(7), 1201-1213. Nature Publishing Group
Grand Challenge PRECISION consortium 2022, ' Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk ', British Journal of Cancer, vol. 127, no. 7, pp. 1201-1213 . https://doi.org/10.1038/s41416-022-01888-2

Background Ductal carcinoma in situ (DCIS) is treated to prevent subsequent ipsilateral invasive breast cancer (iIBC). However, many DCIS lesions will never become invasive. To prevent overtreatment, we need to distinguish harmless from potentially h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaf3af1076b54e78662cd1902b1bde6
https://research.vumc.nl/en/publications/9cd9c8eb-4ba5-491a-8815-1aa6b8db618c

Impact of cancer cell-intrinsic features on neutrophil behavior

Autor: Karin De Visser, Danique Duits

Publikováno v: Seminars in Immunology. 57:101546

Neutrophils are multifaceted innate immune cells that play a significant role in the progression of cancer by exerting both pro- and anti-tumorigenic functions. The crosstalk between cancer cells and neutrophils is complex and emerging evidence is po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e1f48152e48dd4a537f0ac12a67770
https://doi.org/10.1016/j.smim.2021.101546

Retraction: The Chemokine Receptor CXCR6 and Its Ligand CXCL16 Are Expressed in Carcinomas and Inhibit Proliferation

Autor: Karin De Visser, Bas Kreike

Publikováno v: Cancer Research. 71:1196-1196

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ec66df0aa74a96e28ea45ef9c26d425
https://doi.org/10.1158/0008-5472.can-10-4378