Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Karin Conde Knape"'
Autor:
Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Basil Künnecke, Christoph Ullmer, Hugues Matile, Marc Bedoucha, Roger D. Norcross, Nickki Ottaway-Parker, Diego Perez-Tilve, Karin Conde Knape, Matthias H. Tschöp, Marius C. Hoener, Sabine Sewing
Publikováno v:
Molecular Metabolism, Vol 5, Iss 1, Pp 47-56 (2016)
Objective: Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to
Externí odkaz:
https://doaj.org/article/ad2d43af62f34cb681ec8b5659f0cd52
Autor:
Mariette Lengquist, Mathilde Frederikke Bjørn Bonde, G. Kees Hovingh, Heidi Engslev Lund, Bidda Rolin, Stefan Zahn, Michael Nyberg, Karin Hultman, Lars Maegdefessel, Valentina Manfè, Pernille Gry Wulff-Larsen, Karin Conde-Knape, Ulf Hedin, Djordje Djordjevic, Rikke Kaae Kirk, Ljubica Perisic Matic, Niels Blume, Günaj Rakipovski, Maj Petersen, Natasha Barascuk
Publikováno v:
Atherosclerosis, 314, 1-9. Elsevier Ireland Ltd
Background and aims Clinical interventions targeting nonlipid risk factors are needed given the high residual risk of atherothrombotic events despite effective control of dyslipidemia. Dickkopf-1 (DKK1) plays a lipid-independent role in vascular path
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2235-2244 (2004)
The adaptive value of apolipoprotein B-48 (apoB-48), thetruncated form of apoB produced by the intestine, in lipid metabolism remainsunclear. We crossed human apoC-III transgenic mice with mice expressing eitherapoB-48 only (apoB48/48) or apoB-100 on
Externí odkaz:
https://doaj.org/article/18e969c5ab2045febd5d3490248f486d
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2368-2376 (2004)
Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease. Most presenilin is rapidly degraded, and determinants of the
Externí odkaz:
https://doaj.org/article/75a4e3ab9dac4c679a41f188f4d90ae0
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 12, Pp 2136-2145 (2002)
Apolipoprotein C-I (apoC22222222246) has been proposed to act primarily via interference with apoE-mediated lipoprotein uptake. To define actions of apoC-I that are independent of apoE, we crossed a moderately overexpressing human apoC-I transgenic,
Externí odkaz:
https://doaj.org/article/c7369495f16c479d8cc444a658ae8c0d
Autor:
Catherine Godson, Finian Martin, Enda Masterson, Gleb Grebnev, Karin Conde-Knape, Debra F. Higgins, Marco Prunotto, Sylvia Pomposiello, Leah M. Ewart, Sadhbh Tennant
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:3095-3104
Bone morphogenetic protein-7 (BMP-7) counteracts pro-fibrotic effects of TGFβ1 in cultured renal cells and protects from fibrosis in acute and chronic renal injury models. Using the unilateral ureteral obstruction (UUO) model of chronic renal fibros
Autor:
Samantha Solini, Rubina Novelli, Karin Conde-Knape, Giuseppe Remuzzi, Pamela Yossenaidy Rodriguez Ordonez, Marina Noris, Marilena Mister, Monica Cortinovis, Sistiana Aiello, Ariela Benigni
Publikováno v:
Nephron. 144(1)
Background: Tissue fibrosis is the final common phase of chronic allograft injury, the leading cause of late graft loss in kidney transplantation. Preclinical evidence points to the involvement of lysophosphatidic acid (LPA), a bioactive phospholipid
Autor:
Basil Künnecke, Marius C. Hoener, Roger David Norcross, Haiyan Wang, Rubén Alvarez-Sánchez, Christoph Ullmer, Susanne Raab, Diego Perez-Tilve, Matthias H. Tschöp, Sabine Sewing, Marc Bedoucha, Hugues Matile, Nadine Cole, Karin Conde Knape, Nickki Ottaway-Parker, Sabine Uhles
Publikováno v:
Molecular Metabolism, Vol 5, Iss 1, Pp 47-56 (2016)
Molecular Metabolism
Mol. Metab. 5, 47-56 (2016)
Molecular Metabolism
Mol. Metab. 5, 47-56 (2016)
Objective Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to t
Autor:
Rebecca Taub, Robert Alan Goodnow, Lida Qi, Joseph Anthony Bilotta, Sherrie Lynn Pietranico-Cole, Yonglin Ren, Cheryl Spence, Jefferson Wright Tilley, Baolian Liu, Sung-Sau So, Kevin Richard Guertin, Karin Conde-Knape, Matthew Michael Hamilton, Nancy-Ellen Haynes, Kshitij Chhabilbhai Thakkar, Catherine Zwingelstein, Nathan Robert Scott, Paul Gillespie, Michael Paul Myers, Nader Fotouhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2707-2711
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in
Autor:
Irmgard Thorey, Kay Stubenrauch, Sebastian Dziadek, Ulrich Brinkmann, Anish Konkar, Stefan Dengl, Holger Kropp, Karin Conde-Knape, Lothar Kling, Hans-Peter Josel, Eike Hoffmann
Publikováno v:
Journal of Controlled Release. 171:48-56
We applied noncovalent complexes of digoxigenin (Dig) binding antibodies with digoxigeninylated peptide derivatives to modulate their pharmacokinetic properties. A peptide derivative which activates the Y2R receptor was selectively mono-digoxigeninyl