Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Karin Boer"'
Direct detection of circulating donor-derived extracellular vesicles in kidney transplant recipients
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Extracellular vesicles (EVs) are tissue-specific particles containing valuable diagnostic information. However, single EV analysis in blood is challenging due to their physical properties, the molecular complexity of plasma, and a lack of ro
Externí odkaz:
https://doaj.org/article/5df469dd57174599872b3fcd3e47aa19
Autor:
Aleixandra Mendoza Rojas, MSc, Jeroen G.H.P. Verhoeven, MD, Ronella de Kuiper, BSc, Marian C. Clahsen-van Groningen, MD, PhD, Karin Boer, PhD, Dennis A. Hesselink, MD, PhD, Teun van Gelder, MD, PhD, Nicole M. van Besouw, PhD, Carla C. Baan, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 5, p e1478 (2023)
Background. Memory T cells are important mediators of transplant rejection but are not routinely measured before or after kidney transplantation. The aims of this study were as follows: (1) validate whether pretransplant donor-reactive memory T cells
Externí odkaz:
https://doaj.org/article/5637f8ddc18f464e8be94581326bb8e6
Autor:
Wouter W. Woud, Edwin van der Pol, Erik Mul, Martin J. Hoogduijn, Carla C. Baan, Karin Boer, Ana Merino
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A method to quantitate and phenotype Extracellular Vesicles (EVs) in unprocessed human plasma using Imaging Flow Cytometry is presented.
Externí odkaz:
https://doaj.org/article/3f123c13a9224b2cb8e746f039b1bab0
Autor:
Suwasin Udomkarnjananun, MD, Marjolein Dieterich, BSc, Karin Boer, PhD, Dennis A. Hesselink, MD, PhD, Carla C. Baan, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 5, p e1319 (2022)
Externí odkaz:
https://doaj.org/article/7ffc892ebc674463b04f45a90e4d9191
Autor:
Daan P. Hurkmans, Jeroen G. H. P. Verhoeven, Kitty de Leur, Karin Boer, Arjen Joosse, Carla C. Baan, Jan H. von der Thüsen, Ron H. N. van Schaik, Ron H. J. Mathijssen, Astrid A. M. van der Veldt, Dennis A. Hesselink
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-7 (2019)
Abstract Background In solid organ transplant (SOT) recipients, transplant rejection during immune checkpoint inhibitor (ICI) treatment for cancer is a clinical problem. Donor-derived cell-free DNA (dd-cfDNA) can be detected in blood and is a sensiti
Externí odkaz:
https://doaj.org/article/3d6440bf678c4d57bbcc31c40868050e
Autor:
Fleur S. Peters, Annemiek M. A. Peeters, Pooja R. Mandaviya, Joyce B. J. van Meurs, Leo J. Hofland, Jacqueline van de Wetering, Michiel G. H. Betjes, Carla C. Baan, Karin Boer
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Cutaneous squamous cell carcinoma (cSCC) occurs 65–200 times more in immunosuppressed organ transplant patients than in the general population. T cells, which are targeted by the given immunosuppressive drugs, are involved in an
Externí odkaz:
https://doaj.org/article/d94efa70bb4f40a79c4873b34ffbc533
Autor:
Liang Wu, Karin Boer, Wouter W. Woud, Suwasin Udomkarnjananun, Dennis A. Hesselink, Carla C. Baan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10499 (2021)
Extracellular vesicles (EVs) are nanoparticles that transmit molecules from releasing cells to target cells. Recent studies link urinary EVs (uEV) to diverse processes such as infection and rejection after kidney transplantation. This, and the unmet
Externí odkaz:
https://doaj.org/article/6651e1869db244e6af4df0dd18f13976
Autor:
Fleur S. Peters, Annemiek M. A. Peeters, Leo J. Hofland, Michiel G. H. Betjes, Karin Boer, Carla C. Baan
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Immunosuppressive drug therapy is required to treat patients with autoimmune disease and patients who have undergone organ transplantation. The main targets of the immunosuppressive drugs tacrolimus and mycophenolic acid (MPA; the active metabolite o
Externí odkaz:
https://doaj.org/article/e96cd2719b7649c2a102d0ae0e7583bb
Autor:
Teresa Ravizza, Barbara Gagliardi, Francesco Noé, Karin Boer, Eleonora Aronica, Annamaria Vezzani
Publikováno v:
Neurobiology of Disease, Vol 29, Iss 1, Pp 142-160 (2008)
We investigated the activation of the IL-1β system and markers of adaptive immunity in rat brain during epileptogenesis using models of temporal lobe epilepsy (TLE). The same inflammatory markers were studied in rat chronic epileptic tissue and in h
Externí odkaz:
https://doaj.org/article/536eaaf1c42a4ce78d05db24028f496c
Autor:
Suwasin Udomkarnjananun, Marith I. Francke, Marjolein Dieterich, Daan van De Velde, Nicolle H.R. Litjens, Karin Boer, Brenda C.M. De Winter, Carla C. Baan, Dennis A. Hesselink
Publikováno v:
Transplantation, 107(2), 382-391. Lippincott Williams & Wilkins
Background. Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C0). The intra-immune cellular concentration is potentially a better target than C0. However, little is known regarding int