Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Karin Bartel"'
Autor:
Lina Ouologuem, Karin Bartel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Past research has identified that cancer cells sustain several cancer hallmarks by impairing function of the endolysosomal system (ES). Thus, maintaining the functional integrity of endolysosomes is crucial, which heavily relies on two key protein fa
Externí odkaz:
https://doaj.org/article/0f7304cec6484c6bbaebeb6463a181bc
Autor:
Franz Geisslinger, Martin Müller, Yu-Kai Chao, Christian Grimm, Angelika M. Vollmar, Karin Bartel
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-14 (2022)
Abstract Despite novel therapy regimens and extensive research, chemoresistance remains a challenge in leukemia treatment. Of note, recent studies revealed lysosomes as regulators of cell death and chemotherapy response, suggesting this organelle is
Externí odkaz:
https://doaj.org/article/a55e8a39a48d4818944a7025f699aa9d
Autor:
Florian Lengauer, Franz Geisslinger, Antje Gabriel, Karin von Schwarzenberg, Angelika M. Vollmar, Karin Bartel
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
It is widely known that most cancer cells display an increased reliance on glutaminolysis to sustain proliferation and survival. Combining glutamine deprivation with additional anti-cancer therapies is an intensively investigated approach to increase
Externí odkaz:
https://doaj.org/article/c550f5f3982447b595b492730fbb53e5
Autor:
Marco Keller, Karl Sauvageot-Witzku, Franz Geisslinger, Nicole Urban, Michael Schaefer, Karin Bartel, Franz Bracher
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2716-2725 (2021)
We present a systematic investigation on an improved variant of the N-acyl-Pictet–Spengler condensation for the synthesis of 1-benzyltetrahydroisoquinolines, based on our recently published synthesis of N-methylcoclaurine, exemplified by the total
Externí odkaz:
https://doaj.org/article/a76b04de38f9421cb40943bfd05022a1
Autor:
Ponsawan Netcharoensirisuk, Carla Abrahamian, Rachel Tang, Cheng-Chang Chen, Anna Scotto Rosato, Wyatt Beyers, Yu-Kai Chao, Antonio Filippini, Santiago Di Pietro, Karin Bartel, Martin Biel, Angelika M. Vollmar, Kaoru Umehara, Wanchai De-Eknamkul, Christian Grimm
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes. Gain-of-function polymorphisms in hTPC2 are associated with decreased melanin production and blon
Externí odkaz:
https://doaj.org/article/8f4de751c6ed48b481f4c92a2999702f
Autor:
Karin Bartel, Helmut Pein, Bastian Popper, Sabine Schmitt, Sudha Janaki-Raman, Almut Schulze, Florian Lengauer, Andreas Koeberle, Oliver Werz, Hans Zischka, Rolf Müller, Angelika M. Vollmar, Karin von Schwarzenberg
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background The understanding of lysosomes has been expanded in recent research way beyond their view as cellular trash can. Lysosomes are pivotal in regulating metabolism, endocytosis and autophagy and are implicated in cancer. Recently it w
Externí odkaz:
https://doaj.org/article/44f0d07f9d1342d094461524911b0514
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
To date, cancer remains a worldwide leading cause of death, with a still rising incidence. This is essentially caused by the fact, that despite the abundance of therapeutic targets and treatment strategies, insufficient response and multidrug resista
Externí odkaz:
https://doaj.org/article/7764b20afa5b48eb8edccddad63d336f
Autor:
Jürgen Krauß, Christoph Müller, Monika Klimt, Leandro Jorquera Valero, José Francisco Martínez, Martin Müller, Karin Bartel, Ulrike Binder, Franz Bracher
Publikováno v:
Molecules, Vol 26, Iss 23, p 7208 (2021)
The aliphatic heterocycles piperidine and morpholine are core structures of well-known antifungals such as fenpropidin and fenpropimorph, commonly used as agrofungicides, and the related morpholine amorolfine is approved for the treatment of dermal m
Externí odkaz:
https://doaj.org/article/a0f65cc090474ba8b727559d6d19935f
Autor:
Eva Plesch, Cheng-Chang Chen, Elisabeth Butz, Anna Scotto Rosato, Einar K Krogsaeter, Hua Yinan, Karin Bartel, Marco Keller, Dina Robaa, Daniel Teupser, Lesca M Holdt, Angelika M Vollmar, Wolfgang Sippl, Rosa Puertollano, Diego Medina, Martin Biel, Christian Wahl-Schott, Franz Bracher, Christian Grimm
Publikováno v:
eLife, Vol 7 (2018)
Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these inflammatory mediators are released from the various immune cells. Here, the endolysosomal cation c
Externí odkaz:
https://doaj.org/article/502913ae396f43088444672254655b75
Publikováno v:
Pharmaceuticals, Vol 13, Iss 7, p 143 (2020)
The world is currently suffering from a pandemic which has claimed the lives of over 230,000 people to date. The responsible virus is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and causes the coronavirus disease 2019 (COVID-1
Externí odkaz:
https://doaj.org/article/f249cf82dd7f4480b6f1ce1d9f2de39b