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Akademický článek

Active immunization with a Her-2/neu-targeting Multi-peptide B cell vaccine prevents lung metastases formation from Her-2/neu breast cancer in a mouse model

Autor: Joshua Tobias, Mirjana Drinić, Sandra Högler, Katharina Ambroz, Karin Baier, Petra Kodajova, Erwin Tomasich, Anna S. Berghoff, Anna Schmid, Erika Garner-Spitzer, Lukas Kenner, Michael Kundi, Christoph C. Zielinski, Ursula Wiedermann

Publikováno v: Translational Oncology, Vol 19, Iss , Pp 101378- (2022)

In pre-clinical and clinical settings, active immunization with a Her-2/neu vaccine (HerVaxx), comprising B-cell peptide from Trastuzumab binding site, has been shown to reduce primary tumor growth via induction of polyclonal anti-tumor immune respon

Externí odkaz: https://doaj.org/article/7d599b48fb6542b08b70ca40b801fdb5

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Akademický článek

A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors

Autor: Joshua Tobias, Claire Battin, Annika De Sousa Linhares, Michael Lebens, Karin Baier, Katharina Ambroz, Mirjana Drinić, Sandra Högler, Aleksandra Inic-Kanada, Erika Garner-Spitzer, Matthias Preusser, Lukas Kenner, Michael Kundi, Christoph C. Zielinski, Peter Steinberger, Ursula Wiedermann

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Therapeutic monoclonal antibodies (mAbs), targeting tumor antigens, or immune checkpoints, have demonstrated a remarkable anti-tumor effect against various malignancies. However, high costs for mono- or combination therapies, associated with adverse

Externí odkaz: https://doaj.org/article/35ad9cad6fd548f381d461c4dd95deb2

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Abstract 3151: Active immunization with PD1-derived mimotope-Combination immunotherapy against Her-2/neu-expressing tumors

Autor: Michael Lebens, Claire Battin, Matthias Preusser, Christoph C. Zielinski, Peter Steinberger, Ursula Wiedermann, Aleksandra Inic-Kanada, Katharina Ambroz, Joshua Tobias, Erika Garner-Spitzer, Michael Kundi, Karin Baier, Sandra Högler, Annika De Sousa Linhares, Mirjana Drinić, Lukas Kenner

Publikováno v: Cancer Research. 80:3151-3151

Application of monoclonal antibodies (mAbs) as immune checkpoint inhibitors (ICIs) has demonstrated a tremendous effect in cancer immunotherapy. However, high costs for and frequent applications of mono- or combination-therapies or possible developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb19083a1aebd2967b0adacadc0ee3b4
https://doi.org/10.1158/1538-7445.am2020-3151

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Enhanced and long term immunogenicity of a Her-2/neu multi-epitope vaccine conjugated to the carrier CRM197 in conjunction with the adjuvant Montanide

Autor: Christoph C. Zielinski, Joshua Tobias, Ursula Wiedermann, Nicholas J. Ede, Michael Kundi, Karin Baier, Joanna Jasinska

Publikováno v: BMC Cancer

Background We previously identified three short single peptides (P4, P6 and P7) representing different B-cell epitopes on the extracellular domain of Her-2/neu for a vaccine that was tested in a phase-I clinical trial. Here we describe the improvemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b130be3ed683b5932b3ec8f1856b2a78
https://doi.org/10.1186/s12885-017-3098-7

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Interactions of 1α,25-dihydroxyvitamin D3 with IL-12 and IL-4 on cytokine expression of human T lymphocytes

Autor: Martin Willheim, Meinrad Peterlik, Karin Baier, Ralf Thien, Peter Pietschmann

Publikováno v: Journal of Allergy and Clinical Immunology. 116:683-689

1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25[OH](2)D(3)) exerts its effects on the immune system, particularly through suppression of T helper/cytotoxic cell 1 (T(H)/T(C)1)-mediated reactions, although direct actions of 1 alpha,25(OH)(2)D(3) on human T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957b2596a270fa596166a3be26dc7a0e
https://doi.org/10.1016/j.jaci.2005.05.013

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Expression of the B subunit of the heat-labile enterotoxin of Escherichia coli in tobacco mosaic virus-infected Nicotiana benthamiana plants and its characterization as mucosal immunogen and adjuvant

Autor: Christian Radauer, Birgit Wagner, Karin Baier, Karin Hufnagl, Ursula Wiedermann, Heimo Breiteneder, Otto Scheiner, Stefan Wagner

Publikováno v: Journal of Immunological Methods. 287:203-215

We have produced biologically active recombinant (r) LTB, the nontoxic B subunit of heat-labile toxin (LT) of Escherichia coli in tobacco mosaic virus (TMV)-infected Nicotiana benthamiana plants. We amplified the LTB encoding sequence with its leader

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a26d86a1410356b8011ce814cc9a8a
https://doi.org/10.1016/j.jim.2004.02.001

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Phage-displayed Bet mim 1, a mimotope of the major birch pollen allergen Bet v 1, induces B cell responses to the natural antigen using bystander T cell help

Autor: Erika Jensen-Jarolim, Otto Scheiner, Karin Baier, Isabella Schöll, Ursula Wiedermann, C. Ebner, Elisabeth Förster-Waldl, Erika Ganglberger, George Boltz-Nitulescu

Publikováno v: Clinical & Experimental Allergy. 32:1583-1588

Summary Background and objective In previous studies we have generated mimotopes of Bet v 1, the major birch pollen allergen, by biopannings of phage-display random peptide libraries. In the present study, we analysed the humoral and cellular immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12c67ae7c32a2595e14a8becba59c95e
https://doi.org/10.1046/j.1365-2222.2002.01527.x

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Mucosal tolerance as therapy of type I allergy: intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice

Autor: Stefan Wagner, Birgit Winkler, Andreas Repa, Otto Scheiner, H.-G. Eichler, Ursula Wiedermann, D. Kraft, Karin Baier

Publikováno v: Clinical & Experimental Allergy. 32:30-36

Background Several studies have demonstrated that mucosal administration of soluble antigens can prevent the onset or reduce the severity of certain autoimmune diseases or allergies. Few studies exist showing the efficacy of mucosal tolerance for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbd642cdf8fe01fcce84c4a24b10aa9d
https://doi.org/10.1046/j.0022-0477.2001.01214.x

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Intranasal Treatment with a Recombinant Hypoallergenic Derivative of the Major Birch Pollen Allergen Bet v 1 Prevents Allergic Sensitization and Airway Inflammation in Mice

Autor: Gerhard Dekan, Ulrich Neuhaus-Steinmetz, Dietrich Kraft, Susanne Vrtala, Christof Ebner, Ursula Wiedermann, Karin Baier, Rudolf Valenta, Udo Herz, Barbara Bohle, Harald Renz

Publikováno v: International Archives of Allergy and Immunology. 126:68-77

Background: The major birch pollen allergen Bet v 1 represents one of the most prevalent environmental allergens responsible for allergic airway inflammation. Objective: In the present study we sought to compare the complete recombinant Bet v 1 aller

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7509df9ea3f638df1ebce4ca451a5451
https://doi.org/10.1159/000049496

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