Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology

Autor: Diane van der Woude, M. Volkov, Karin Anna van Schie

Publikováno v: Immunological Reviews

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. In the last few decades, new insights into RA‐specific autoantibodies and B cells have greatly expanded our understanding of the disease. The best‐known autoa

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On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis

Autor: Anders Lundquist, Heidi Kokkonen, Manfred Wuhrer, René E. M. Toes, Lise Hafkenscheid, Solbritt Rantapää-Dahlqvist, Theresa Kissel, Karin Anna van Schie, Hans Scherer, Tom W J Huizinga

Publikováno v: Annals of the rheumatic diseases, 78(12), 1616-1620. BMJ Publishing Group
Annals of the Rheumatic Diseases, 78(12), 1616-1620
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 78(12), 1616-1620. BMJ PUBLISHING GROUP

ObjectiveAnti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients display a unique feature defined by the abundant presence of N-linked glycans within the variable domains (V-domains). Recently, we showed that N-glycosylatio

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