Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response

Autor: Tom W J Huizinga, Diane van der Woude, René E M Toes, Mikhail Volkov, Peter A van Veelen, Joanneke C Kwekkeboom, Karin A J van Schie, Arieke S B Kampstra, Anouk G van Mourik, Arnoud de Ru

Publikováno v: RMD Open, Vol 10, Iss 3 (2024)

Objective Gut-residing bacteria, such as Escherichia coli, can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut) microbiome is involved in the breach of immune tolerance to modified self-proteins leading t

Externí odkaz: https://doaj.org/article/9c5b5041e28d4dc9a561bd66be48dfdc

Multifunctional, Multivalent PIC Polymer Scaffolds for Targeting Antigen-Specific, Autoreactive B Cells

Autor: Hendy Kristyanto, Miles D. Holborough-Kerkvliet, Lianne Lelieveldt, Yvonne Bartels, Roel Hammink, Karin A. J. van Schie, Rene E. M. Toes, Kimberly M. Bonger, Hans Ulrich Scherer

Publikováno v: Acs Biomaterials Science & Engineering, 8, 1486-1493
Acs Biomaterials Science & Engineering, 8, 4, pp. 1486-1493
ACS biomaterials science & engineering

Multivalent scaffolds that carry multiple molecules with immunophenotyping or immunomodulatory properties are invaluable tools for studying and modulating specific functions of human immune responses. So far, streptavidin-biotin-based tetramers have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b78bb268ca5c20deedd75a8b1cd94d
https://doi.org/10.1021/acsbiomaterials.1c01395