Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Karin, van Breda"'
Autor:
Geoffrey W. Birrell, Karin Van Breda, Bridget Barber, Rebecca Webster, James S. McCarthy, G. Dennis Shanks, Michael D. Edstein
Publikováno v:
Molecules, Vol 27, Iss 23, p 8186 (2022)
Analytical methods for the quantification of the new 8-aminoquinoline antimalarial tafenoquine (TQ) in human blood, plasma and urine, and the 5,6-orthoquinone tafenoquine metabolite (5,6-OQTQ) in human plasma and urine have been validated. The proced
Externí odkaz:
https://doaj.org/article/07f064c3dee24f319708a67256df9d7a
Autor:
Chu Xuan Anh, Karin van Breda, G. Dennis Shanks, Anton Lord, Thomas Travers, Kerryn Rowcliffe, Michael D. Edstein, Marina Chavchich, Geoffrey W. Birrell
Publikováno v:
Antimicrob Agents Chemother
High rates of artemisinin-based combination therapy (ACT) failures in the treatment of Plasmodium falciparum malaria in Southeast Asia have led to triple-drug strategies to extend the useful life of ACTs. In this study, we determined whether methylen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5199fdc7a46aafb6dbfb8e4d7e1a7e2b
https://doi.org/10.1128/aac.01441-19
https://doi.org/10.1128/aac.01441-19
Autor:
Marina Chavchich, David P. Jacobus, Karin van Breda, Geoffrey W. Birrell, Gavin D. Heffernan, Michael D. Edstein, Dennis Shanks, Nicanor Obaldia, Fiona J. McCallum, Ivor Harris
Publikováno v:
Antimicrob Agents Chemother
Nonimmune Aotus monkeys infected with Plasmodium falciparum and Plasmodium vivax were cured of their infections when treated with a single oral dose of 5 mg/kg and 10 mg/kg of the 2-aminomethylphenol, JPC-3210, respectively. Corresponding mean blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965ec753300c3cab978dea19e85e6565
https://europepmc.org/articles/PMC7038259/
https://europepmc.org/articles/PMC7038259/
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:5167-5174
In vitro drug treatment with artemisinin derivatives, such as dihydroartemisinin (DHA), results in a temporary growth arrest (i.e., dormancy) at an early ring stage in Plasmodium falciparum . This response has been proposed to play a role in the recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352cf0acedc92da15f458b477ee7cb30
https://doi.org/10.1128/aac.02838-15
https://doi.org/10.1128/aac.02838-15
Autor:
Michael D. Edstein, Ivor Harris, Danielle I. Stanisic, Karin van Breda, Bernadette Bellete, Fiona J. McCallum, Sai Lata De, Michael F. Good
Publikováno v:
International Journal for Parasitology. 46:581-591
Malaria is a disease caused by a protozoan of the Plasmodium genus and results in 0.5–0.7 million deaths per year. Increasing drug resistance of the parasite and insecticide resistance of mosquitoes necessitate alternative control measures. Numerou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4002347b819439ccbc527f5ccbd04a
https://doi.org/10.1016/j.ijpara.2016.05.002
https://doi.org/10.1016/j.ijpara.2016.05.002
Autor:
Kerryn Rowcliffe, Karin van Breda, Nguyen Ngoc Quang, Geoffrey W. Birrell, Chu Xuan Anh, Marina Chavchich, Thomas Travers, Michael D. Edstein
The pharmacokinetics (PK) and ex vivo activity (pharmacodynamics [PD]) of two artemisinin combination therapies (ACTs) (artemisinin–piperaquine [ARN–PPQ] [Artequick(®)] and artesunate–amodiaquine [ARS–AQ] [Coarsucam(™)]) in healthy Vietnam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c545ced2274ef6cf21833375df259bec
https://europepmc.org/articles/PMC6085815/
https://europepmc.org/articles/PMC6085815/
Autor:
David P. Jacobus, Donna Mackenzie, Arba L. Ager, Gavin D. Heffernan, Pablo Rafael Morales, Karin van Breda, Laura R. Jacobus, John W. Anderson, G. Dennis Shanks, Guy A. Schiehser, Michael D. Edstein, Geoffrey W. Birrell, Marina Chavchich
The new 2-aminomethylphenol, JPC-3210, has potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, and high in vivo efficacy against murine malaria. Here we report on the pharmacokinetics of JP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afac86c4aba387dd5d00ed154ef9572
https://europepmc.org/articles/PMC5913937/
https://europepmc.org/articles/PMC5913937/
Autor:
Ross Norris, Ross Pinkerton, Thu H.M. Nguyen, Karin van Breda, Ming Ni, John A. Duley, Andrew S. Moore, Gareth Price, Rani George, Bruce G. Charles
Publikováno v:
Journal of Paediatrics and Child Health. 47:875-882
Background: Vincristine is a key component of many childhood cancer treatment regimens. Pharmacodynamic parameters such as clinical efficacy and toxicity may be influenced by polymorphisms of CYP3A. Aim: The aim of this study was to document CYP3A5 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d78f773c4909a1c8cd18f714b57f95c
https://doi.org/10.1111/j.1440-1754.2011.02103.x
https://doi.org/10.1111/j.1440-1754.2011.02103.x
Autor:
Michael D. Edstein, Danielle I. Stanisic, Ivor Harris, Fiona J. McCallum, Karin van Breda, Sai Lata De, Michael F. Good, David P. Jacobus
Publikováno v:
Antimicrobial agents and chemotherapy. 60(3)
Previously, we reported JPC-2997 [4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol] to possess high in vitro antimalarial activity against Plasmodium falciparum lines, low cytotoxicity in mammalian cell lines, a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cabb45e14e45ecf3eefd4aa3faeb02
https://pubmed.ncbi.nlm.nih.gov/26666945
https://pubmed.ncbi.nlm.nih.gov/26666945
Autor:
Alison, Haywood, Anthony, Burrell, Karin van, Breda, Rani, George, Chris, Testa, Ross, Norris
Publikováno v:
International journal of pharmaceutical compounding. 13(2)
This study examined the stability of melatonin in a 10-mg/mL oral sublingual solution stored at 4 deg C or 25 deg C and in 3-mg capsules stored at ambient (25 deg C; 60% relative humidity) and accelerated (40 deg C; 75% relative humidity) conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d24529132b3f3c228bc81c7d5a431986
https://pubmed.ncbi.nlm.nih.gov/23970011
https://pubmed.ncbi.nlm.nih.gov/23970011