Výsledky vyhledávání - "Karin, Weening"

Akademický článek

Virus–Host Protein Interaction Network of the Hepatitis E Virus ORF2-4 by Mammalian Two-Hybrid Assays

Autor: Laura Corneillie, Irma Lemmens, Karin Weening, Amse De Meyer, Freya Van Houtte, Jan Tavernier, Philip Meuleman

Publikováno v: Viruses, Vol 15, Iss 12, p 2412 (2023)

Throughout their life cycle, viruses interact with cellular host factors, thereby influencing propagation, host range, cell tropism and pathogenesis. The hepatitis E virus (HEV) is an underestimated RNA virus in which knowledge of the virus–host in

Externí odkaz: https://doaj.org/article/23e11388b4bb41cb8d0c3e7a62c97abd

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Akademický článek

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Autor: Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)

T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)-

Externí odkaz: https://doaj.org/article/b8d37350b35e4c9e9ca7c2af1a96b344

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Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage

Publikováno v: JOURNAL OF EXPERIMENTAL MEDICINE

Billiet et al. identify the post-thymic progeny of the agonist-selected CD10(+) PD-1(+) precursors in humans based on shared characteristics of the T cell receptor repertoire and the transcriptome. This lineage represents a well-defined but heterogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb2709fc96a8b395ba17769f1460ee0
https://biblio.ugent.be/publication/01H32AFRDVK3SC2WQW4NA0DG5Z/file/01H32AGM1QN46XV5BFJWVGT2X3

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Akademický článek

Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a– CD95+ CD28– CCR7– Developmental Stage

Autor: Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, Tessa Kerre, Tom Taghon, Georges Leclercq, Bart Vandekerckhove

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 22, p 8785 (2020)

Human thymic CD8αα+ CD10+ PD-1+ αβ T cells selected through early agonist selection have been proposed as the putative thymic precursors of the human CD8αα+ intestinal intraepithelial lymphocytes (IELs). However, the progeny of these thymic pre

Externí odkaz: https://doaj.org/article/f15cf268ed5b4742a78571f56d5abebd

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Akademický článek

Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly

Autor: Stijn De Munter, Alexander Van Parys, Layla Bral, Joline Ingels, Glenn Goetgeluk, Sarah Bonte, Melissa Pille, Lore Billiet, Karin Weening, Annick Verhee, Jose Van der Heyden, Tom Taghon, Georges Leclercq, Tessa Kerre, Jan Tavernier, Bart Vandekerckhove

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 3, p 883 (2020)

Recent approval of chimeric antigen receptor (CAR) T cell therapy by the European Medicines Agency (EMA)/Federal and Drug Administration (FDA) and the remarkable results of CAR T clinical trials illustrate the curative potential of this therapy. Whil

Externí odkaz: https://doaj.org/article/83a54f189b9d4f34951f075863969ccb

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Akademický článek

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Autor: Yasmine Van Caeneghem, Stijn De Munter, Paola Tieppo, Glenn Goetgeluk, Karin Weening, Greet Verstichel, Sarah Bonte, Tom Taghon, Georges Leclercq, Tessa Kerre, Reno Debets, David Vermijlen, Hinrich Abken, Bart Vandekerckhove

Publikováno v: OncoImmunology, Vol 6, Iss 3 (2017)

Recent clinical studies indicate that adoptive T-cell therapy and especially chimeric antigen receptor (CAR) T-cell therapy is a very potent and potentially curative treatment for B-lineage hematologic malignancies. Currently, autologous peripheral b

Externí odkaz: https://doaj.org/article/20e75ad2cb564c7c8a949cd5e8b92798

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Single-cell profiling identifies a spectrum of human unconventional intraepithelial T lineage cells

In the human thymus, a CD10+ PD-1+ TCRαβ+ differentiation pathway diverges from the conventional single positive T cell lineages at the early double positive stage. These cells are phenotypically and functionally similar to murine unconventional in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aa90518c258da3c0d8b6420ba87e9db
https://doi.org/10.1101/2022.05.24.492634

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Akademický článek

Nanobody Based Dual Specific CARs

Autor: Stijn De Munter, Joline Ingels, Glenn Goetgeluk, Sarah Bonte, Melissa Pille, Karin Weening, Tessa Kerre, Hinrich Abken, Bart Vandekerckhove

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 2, p 403 (2018)

Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas. However, targeting a single antigen may not be sufficient

Externí odkaz: https://doaj.org/article/8d25e0a8c29147be8a3f5b337bb838e7

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