Výsledky vyhledávání - "Karin, Wåhlander"

Fibrinolysis inhibitors in plaque stability: a morphological association of PAI‐1 and TAFI in advanced carotid plaque

Autor: A.-C. Jönsson Rylander, Göran Bergström, A. Lindgren, G. Böttcher, Johanna Deinum, Karin Wåhlander, Inge Kalies

Publikováno v: Journal of Thrombosis and Haemostasis. 15:758-769

Essentials Fibrinolysis inhibitors are localized in advanced atheroma by immunohistology of endarterectomies. Neovascular endothelium/neocapillaries show thrombin-activatable fibrinolysis inhibitor (TAFI). Macrophage areas show free plasminogen activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cf2086cb83b626a9554f0178ccdf34
https://doi.org/10.1111/jth.13641

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Development of Human Target Validation Classification that Predicts Future Clinical Efficacy

Autor: Peter J. Greasley, Cecilia Karlsson, Karin Wåhlander, David Gustafsson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 368(2)

Fewer new medicines have become available to patients during the last decades. Clinical efficacy failures in late-phase development have been identified as a common cause of this decline. Improved ways to ensure early selection of the right drug targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c7d2269232949078e1b9051e821188
https://pubmed.ncbi.nlm.nih.gov/30482795

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Exposure-response for biomarkers of anticoagulant effects by the oral direct thrombin inhibitor AZD0837 in patients with atrial fibrillation

Autor: S. Bertil Olsson, Ulf Eriksson, Lars Hvilsted Rasmussen, Gregory Y.H. Lip, Karin Wåhlander, Eva C. Jensen, Bengt Hamrén

Publikováno v: British Journal of Clinical Pharmacology. 80:1362-1373

AZD0837 is a novel oral anticoagulant investigated in clinical studies for stroke prevention in patients with atrial fibrillation (AF). It is bioconverted to its active form, AR-H067637, a potent, specific and reversible thrombin inhibitor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::623196d2bad709b97ce1a71cfbb46752
https://doi.org/10.1111/bcp.12719

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Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes

Autor: Carina Ämmälä, Patrik Rorsman, Sten Orrenius, Anders Hallberg, Lisa Juntti-Berggren, Krister Bokvist, Jeanette M. Dypbukt, Per Olof Berggren, Karin Wåhlander, Pierluigi Nicotera, Olof Larsson

Type I diabetes [insulin-dependent diabetes mellitus (IDDM)] is an autoimmune disease associated with the destruction of pancreatic beta cells. Serum from patients with IDDM increased L-type calcium channel activity of insulin-producing cells and of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2521cbcbaffd530ebede9a86e968965
https://ora.ox.ac.uk/objects/uuid:d2e4ffa7-58ef-4645-b324-9e286800cf6b

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Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells

Autor: Per Olof Berggren, Patrik Rorsman, Krister Bokvist, Carina Ämmälä, Karin Wåhlander

The effects of alpha 2-adrenergic stimulation on the Ca(2+)-current in mouse pancreatic beta-cells were investigated using the patch-clamp technique. When using the conventional whole-cell recording configuration (dialysis of cell interior with pipet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee3b116b46e02721f7dcea02d346942
https://doi.org/10.1007/bf01182483

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Developing New Treatments for Heart Failure

Publikováno v: Circulation: Heart Failure. 9

Compared with heart failure (HF) care 20 to 30 years ago, there has been tremendous advancement in therapy for ambulatory HF with reduced ejection fraction with the use of agents that block maladaptive neurohormonal pathways. However, during the past

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c540020e7607a7727863a20474b12e12
https://doi.org/10.1161/circheartfailure.115.002727

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Insulin resistance, endothelial function, angiogenic factors and clinical outcome in non-diabetic patients with chest pain without myocardial perfusion defects

Autor: Jan Oscarsson, Remi A. Momo, Li-Ming Gan, Peter J. Greasley, Erika Rehnström, Regina Fritsche-Danielson, Sara Svedlund, Helena U. Westergren, Juuso I. Blomster, Karin Wåhlander

Publikováno v: Cardiovascular Diabetology

Background Patients with angina-like symptoms without myocardial perfusion scintigram (MPS)-verified abnormality may still be at risk for cardiovascular events. We hypothesized that insulin resistance could play a role in this population even without

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d84406dd9e9ddec03187a08184d48c
https://doi.org/10.1186/s12933-016-0353-1

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Histone deacetylase inhibitors stimulate tissue-type plasminogen activator production in vascular endothelial cells

Autor: Lena Karlsson, Mia Magnusson, Emma Lu, Karin Wåhlander, Sverker Jern, Pia Larsson, Niklas Bergh, Erik Ulfhammer

Publikováno v: Journal of Thrombosis and Thrombolysis. 35:185-192

A reduced capacity for acute tissue-type plasminogen activator (t-PA) release is likely to be associated with an impaired endogenous defense against intravascular thrombosis. Efficient approaches to pharmacologically restore a defective t-PA release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd21761f0e1bbe653b862c75f83b529
https://doi.org/10.1007/s11239-012-0831-6

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