Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Karin, Soller"'
Autor:
Sara Montserrat-Vazquez, Noelle J. Ali, Francesca Matteini, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Sacma, Vadim Sakk, Loris Mularoni, Jan Philipp Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, M. Carolina Florian
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-17 (2022)
Abstract One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking. He
Externí odkaz:
https://doaj.org/article/a4bb8c5a146d41029eb29433f0022be5
Autor:
Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSC). We report increased frequencies of HSC, hematopoietic progenitor cells and lineage negative cells in the elderly but a decreased frequency of multi-lymphoi
Externí odkaz:
https://doaj.org/article/f412a1c316754eae9e008f8f750efa0f
Autor:
Ani Grigoryan, Novella Guidi, Katharina Senger, Thomas Liehr, Karin Soller, Gina Marka, Angelika Vollmer, Yolanda Markaki, Heinrich Leonhardt, Christian Buske, Daniel B. Lipka, Christoph Plass, Yi Zheng, Medhanie A. Mulaw, Hartmut Geiger, Maria Carolina Florian
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-21 (2018)
Abstract Background The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and hi
Externí odkaz:
https://doaj.org/article/d09855951acf45d1acdccc0a55836829
Autor:
Sachin Kumar, Jeffrey D Vassallo, Kalpana J Nattamai, Aishlin Hassan, Rebekah Karns, Angelika Vollmer, Karin Soller, Vadim Sakk, Mehmet Sacma, Travis Nemkov, Angelo D'Alessandro, Hartmut Geiger
Publikováno v:
EMBO reports. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55ace1faf8253303aa4a1a55a1c6a4a
https://doi.org/10.15252/embr.202255373
https://doi.org/10.15252/embr.202255373
Autor:
Bettina M. Moehrle, Kalpana Nattamai, Andreas Brown, Maria C. Florian, Marnie Ryan, Mona Vogel, Corinna Bliederhaeuser, Karin Soller, Daniel R. Prows, Amir Abdollahi, David Schleimer, Dagmar Walter, Michael D. Milsom, Peter Stambrook, Matthew Porteus, Hartmut Geiger
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2412-2424 (2015)
Whether aged hematopoietic stem and progenitor cells (HSPCs) have impaired DNA damage repair is controversial. Using a combination of DNA mutation indicator assays, we observe a 2- to 3-fold increase in the number of DNA mutations in the hematopoieti
Externí odkaz:
https://doaj.org/article/13b5feae53e44badb1081c6fc750e3c0
Autor:
M Carolina Florian, Markus Klose, Mehmet Sacma, Jelena Jablanovic, Luke Knudson, Kalpana J Nattamai, Gina Marka, Angelika Vollmer, Karin Soller, Vadim Sakk, Nina Cabezas-Wallscheid, Yi Zheng, Medhanie A Mulaw, Ingmar Glauche, Hartmut Geiger
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2003389 (2018)
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control prot
Externí odkaz:
https://doaj.org/article/edd84f3477ed491c831b529cfab0e5ea
Autor:
Mehmet, Saçma, Francesca, Matteini, Medhanie A, Mulaw, Ali, Hageb, Ruzhica, Bogeska, Vadim, Sakk, Angelika, Vollmer, Gina, Marka, Karin, Soller, Michael D, Milsom, Maria Carolina, Florian, Hartmut, Geiger
Publikováno v:
STAR protocols. 3(3)
Quantitative 3D imaging of organ-wide cellular and subcellular components is central for revealing and understanding complex interactions between stem cells and their microenvironment. Here, we present a gentle but fast whole-mount immunofluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c15b7039ee54c36cb8409e0ca8a73f6f
https://pubmed.ncbi.nlm.nih.gov/35769923
https://pubmed.ncbi.nlm.nih.gov/35769923
Autor:
Karina Eiwen, Ani Grigoryan, Yi Zheng, Katharina Senger, Matthias Gaestel, Karin Soller, Tanja Schuster, Vadim Sakk, Hartmut Geiger, Manoj B. Menon, Ravinder Kandi, Maria Carolina Florian
Publikováno v:
EMBO Reports
Aging of hematopoietic stem cells (HSCs) is caused by the elevated activity of the small RhoGTPase Cdc42 and an apolar distribution of proteins. Mechanisms by which Cdc42 activity controls polarity of HSCs are not known. Binder of RhoGTPases proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eb17481e17b8d4e0801fad890bef99
http://europepmc.org/articles/PMC8647144
http://europepmc.org/articles/PMC8647144
Autor:
Schuster T, Yi Zheng, Katharina Senger, Sakk, Karin Soller, Manoj B. Menon, Hartmut Geiger, Karina Eiwen, Kandi R, Ani Grigoryan, Carolina Florian M, Matthias Gaestel
Aging of hematopoietic stem cells (HSCs) is caused by an elevated activity of the small RhoGTPase Cdc42 and an apolar distribution of proteins. Mechanisms by which Cdc42 activity controls polarity of HSCs are not known. Binder of RhoGTPases proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b35f36457d5d78b46c9b45ce371f2d
https://doi.org/10.1101/2021.03.17.435817
https://doi.org/10.1101/2021.03.17.435817
Autor:
Kalpana Nattamai, Karin Soller, Maria Carolina Florian, Nikhil Oommen George, Hartmut Geiger, Karin Scharffetter-Kochanek, Rajiv Lochan Tiwari, Nicola Martin, Kodandaramireddy Nalapareddy, Vadim Sakk, Pratibha Mishra
Publikováno v:
Aging (Albany NY)
Normal hair growth occurs in cycles, comprising growth (anagen), cessation (catagen) and rest (telogen). Upon aging, the initiation of anagen is significantly delayed, which results in impaired hair regeneration. Hair regeneration is driven by hair f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef1d02f4ae817633ee8d9d91f15f3b7
https://doi.org/10.21203/rs.3.rs-95907/v1
https://doi.org/10.21203/rs.3.rs-95907/v1