Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karima El Ouadrani"'
Autor:
Christian Gespach, Gerry Melino, Olivier De Wever, Shahin Emami, Ann Hendrix, Karima El Ouadrani, Jean-Pierre Roperch
Supplementary Figure 2 from Netrin-1 Induces Apoptosis in Human Cervical Tumor Cells via the TAp73α Tumor Suppressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd2698ab977381dd0289ba8b9a0c013
https://doi.org/10.1158/0008-5472.22377305
https://doi.org/10.1158/0008-5472.22377305
Autor:
Christian Gespach, Gerry Melino, Olivier De Wever, Shahin Emami, Ann Hendrix, Karima El Ouadrani, Jean-Pierre Roperch
Supplementary Figure 1 from Netrin-1 Induces Apoptosis in Human Cervical Tumor Cells via the TAp73α Tumor Suppressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55257ed93ae41b4f1eaa256ea7c4a0ad
https://doi.org/10.1158/0008-5472.22377308
https://doi.org/10.1158/0008-5472.22377308
Autor:
Christophe Tournigand, Virginie F. Mégalophonos, Pascale Cervera, Aude Battistella, Benoist Chibaudel, Sylvie Dumont, Pascaline Boudou, Thierry André, Jean-François Fléjou, Aimery de Gramont, Nyam Kamsu-Kom, Virginie Poindessous, Annette K. Larsen, Djamila Ouaret, Alexandre E. Escargueil, Amélie Petitprez, Karima El Ouadrani
Publikováno v:
Clinical Cancer Research. 17:6522-6530
Purpose: Epidermal growth factor receptor (EGFR) and VEGF(R) signaling show extensive cross-talk, providing a rationale for joint targeting of the two pathways. However, combinations of monoclonal antibodies (mAb) targeting EGFR and VEGF showed disap
Autor:
Celine J. Rocca, Virginie Poindessous, Alain Sarasin, Alexandre E. Escargueil, Annette K. Larsen, Eric Guérin, João Antonio Pêgas Henriques, Aimery de Gramont, Daniele G. Soares, Karima El Ouadrani
Publikováno v:
Biochemical Pharmacology. 80:335-343
S23906 belongs to a novel class of alkylating anticancer agents forming bulky monofunctional DNA adducts. A unique feature of S23906 is its "helicase-like" activity leading to the destabilization of the surrounding duplex DNA. We here characterize th
Publikováno v:
Pharmacologytherapeutics. 131(1)
The last decade has witnessed the approval of monoclonal antibodies (mAbs) and small molecule tyrosine kinase inhibitors (TKIs) for targeting of oncogenic signaling pathways. Generally, the clinical activity of these agents has been less than expecte
Autor:
Gerry Melino, Ann Hendrix, Karima El Ouadrani, Jean Pierre Roperch, Christian Gespach, Olivier De Wever, Shahin Emami
Publikováno v:
Cancer research. 68(20)
Netrins and their receptors deleted in colon cancer (DCC), neogenin, UNC5, and integrins are involved in axon guidance, epithelial morphogenesis, vascular pattering, cancer cell survival, invasion, tumor angiogenesis, and metastasis. Here, we conside
Autor:
Pascale Cervera, Christophe Louvet, Djamila Ouaret, Karima El Ouadrani, Pascaline Boudou, Alexandre E. Escargueil, Jean-François Fléjou, Virginie Poindessous, Christophe Tournigand, Nyam Kamsu‐Kom, Annette K. Larsen, Amélie Petitprez, Aimery de Gramont, Sylvie Dumont
Publikováno v:
Molecular Cancer Therapeutics. 8:A240-A240
Backgound: Combining different classes of targeted agents represents a major challenge in modern cancer therapy. Agents targeting EGFR- or VEGF-signaling are approved for treatment of metastatic colorectal cancer paving the way for novel therapeutic
Autor:
Alain Sarasin, Karima El Ouadrani, Eric Guérin, João Antonio Pêgas Henriques, Alexandre E. Escargueil, Aimery de Gramont, Celine J. Rocca, Daniele G. Soares, Annette K. Larsen, Virginie Poindessous
Publikováno v:
Molecular Cancer Therapeutics. 8:A125-A125
Backgound: Nucleotide excision repair (NER) is one of our most versatile DNA repair pathways. NER plays an important role in the repair of platinum adducts, and expression levels of the ERCC1 endonuclease, the last step in the NER process, is widely