Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Karima El Bagdadi"'
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Akademický článek
β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis
Autor: Gundula Rösch, Dominique Muschter, Shahed Taheri, Karima El Bagdadi, Christoph Dorn, Andrea Meurer, Frank Zaucke, Arndt F. Schilling, Susanne Grässel, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Publikováno v: Frontiers in Immunology, Vol 12 (2022)
PurposeRecent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the imp
Externí odkaz: https://doaj.org/article/5c0a86ee5417455389e968e0473b4ae6
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3
Sympathectomy aggravates subchondral bone changes during osteoarthritis progression in mice without affecting cartilage degeneration or synovial inflammation
Autor: Susanne Grässel, Andrea Meurer, Shahed Taheri, Karima El Bagdadi, Arndt F. Schilling, Rainer H. Straub, Gundula Rösch, Frank Zaucke, Dominique Muschter, Zsuzsa Jenei-Lanzl, Christoph Dorn
Publikováno v: Osteoarthritis and Cartilage. 30:461-474
Summary Objective Osteoarthritis (OA) pathogenesis involves the interaction of articular cartilage with surrounding tissues, which are innervated by tyrosine hydroxylase-positive (TH+) sympathetic nerve fibers suggesting a role of the sympathetic ner
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545f9aefd37b4d350326e5ff58c8b492
https://doi.org/10.1016/j.joca.2021.11.016
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4
β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis
Autor: Gundula Rösch, Dominique Muschter, Shahed Taheri, Karima El Bagdadi, Christoph Dorn, Andrea Meurer, Frank Zaucke, Arndt F. Schilling, Susanne Grässel, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2022)
PurposeRecent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the imp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ee51d62f00b782dba237449a2e655a
https://pubmed.ncbi.nlm.nih.gov/35095883
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7
Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation
Autor: Rainer H. Straub, Peter Angele, Susanne Grässel, Jessica Hedderich, Frank Zaucke, Andrea Meurer, Zsuzsa Jenei-Lanzl, Karima El Bagdadi
Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 3924, p 3924 (2020)
Bone marrow-derived mesenchymal stem cells (BMSCs) represent an alternative to chondrocytes to support cartilage regeneration in osteoarthritis (OA). The sympathetic neurotransmitter norepinephrine (NE) has been shown to inhibit their chondrogenic po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386d28917f4c014f1917d59f5f7f91e4
http://europepmc.org/articles/PMC7312191
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8
Adrenoceptor Expression during Intervertebral Disc Degeneration
Autor: C. Fleege, Richard Bostelmann, Andrea Meurer, Frank Zaucke, Karima El Bagdadi, Johannes Kupka, M. Rickert, Daniel W. Chan, Marco Brenneis, Zsuzsa Jenei-Lanzl, Annika Kohler
Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2085 (2020)
Healthy and degenerating intervertebral discs (IVDs) are innervated by sympathetic nerves, however, adrenoceptor (AR) expression and functionality have never been investigated systematically. Therefore, AR gene expression was analyzed in both tissue
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eee6fec75e1a4545b2fc64328dc2bbe
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9
Platelet‐rich fibrin‐based matrices to improve angiogenesis in an in vitro co‐culture model for bone tissue engineering
Autor: Joseph Choukroun, Robert Sader, Eva Dohle, Shahram Ghanaati, C. James Kirkpatrick, Karima El Bagdadi
Publikováno v: Journal of Tissue Engineering and Regenerative Medicine
In the context of prevascularization strategies for tissue‐engineering purposes, co‐culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee5b0ca47e33c02884ed541c1e9029d
https://doi.org/10.1002/term.2475
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10
Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via α2a-Adrenoceptor-Mediated ERK1/2 Activation
Autor: Zsuzsa Jenei-Lanzl, Rainer H. Straub, Karima El Bagdadi, Frank Zaucke, Andrea Meurer
Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 13
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3127 (2019)
In recent years, first evidences emerged that sympathetic neurotransmitters influence osteoarthritis (OA) manifestation. Joint-resident stem cells might contribute to cartilage repair, however, their chondrogenic function is reduced. The neurotransmi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b42132167c025fb93ee654ec0c3d43
https://epub.uni-regensburg.de/41536/
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