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Akademický článek

Measuring Single-Cell Calcium Dynamics Using a Myofilament-Localized Optical Biosensor in hiPSC-CMs Derived from DCM Patients

Autor: Cara Hawey, Kyla Bourque, Karima Alim, Ida Derish, Elise Rody, Kashif Khan, Natalie Gendron, Renzo Cecere, Nadia Giannetti, Terence E. Hébert

Publikováno v: Cells, Vol 12, Iss 21, p 2526 (2023)

Synchronized contractions of cardiomyocytes within the heart are tightly coupled to electrical stimulation known as excitation-contraction coupling. Calcium plays a key role in this process and dysregulated calcium handling can significantly impair c

Externí odkaz: https://doaj.org/article/da7b8d0f937c4f05a45490f5cdc7c18c

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Akademický článek

Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study

Autor: Benjamin Lefranc, Karima Alim, Cindy Neveu, Olivier Le Marec, Christophe Dubessy, Jean A. Boutin, Julien Chuquet, David Vaudry, Gaëtan Prévost, Marie Picot, Hubert Vaudry, Nicolas Chartrel, Jérôme Leprince

Publikováno v: Molecules, Vol 26, Iss 14, p 4312 (2021)

26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of physiological processes including feeding behavior and glucose homeostasis. He

Externí odkaz: https://doaj.org/article/387126f726f94c0f9fcba719762d6ccd

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Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients

Autor: Kyla Bourque, Ida Derish, Cara Hawey, Jace Jones-Tabah, Kashif Khan, Karima Alim, Alyson Jiang, Hooman Sadighian, Jeremy Zwaig, Natalie Gendron, Renzo Cecere, Nadia Giannetti, Terence E. Hébert

Dilated cardiomyopathy (DCM) is a cardiovascular condition that develops when the left ventricle of the heart enlarges, compromising its function and diminishing its capacity to pump oxygenated blood throughout the body. After patients are diagnosed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95f0faa3b14e8ea6ddb5d376cf0f3039
https://doi.org/10.1101/2022.09.06.506800

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Differential Inhibition of Equilibrative Nucleoside Transporter 1 (ENT1) Activity by Tyrosine Kinase Inhibitors

Autor: Claire Denizot, Karima Alim, Amélie Moreau, Olivier Fardel, Yannick Parmentier, Elodie Jouan, Arnaud Bruyère

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics
European journal of drug metabolism and pharmacokinetics
European journal of drug metabolism and pharmacokinetics, Springer, 2021, 46 (5), pp.625-635. ⟨10.1007/s13318-021-00703-2⟩
European journal of drug metabolism and pharmacokinetics, 2021, 46 (5), pp.625-635. ⟨10.1007/s13318-021-00703-2⟩

International audience; Background and Objectives Equilibrative nucleoside transporter (ENT) 1 is a widely-expressed drug transporter, handling nucleoside analogues as well as endogenous nucleosides. ENT1 has been postulated to be inhibited by some m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535a074bd5d0488c39d3fd8644352eaf
http://europepmc.org/articles/PMC8286641

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Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors

Autor: Anne T. Nies, Karima Alim, Elodie Jouan, Arnaud Bruyère, Amélie Moreau, Olivier Fardel, Yannick Parmentier, Claire Denizot

Publikováno v: Fundamental & Clinical Pharmacology
Fundamental & Clinical Pharmacology, 2021, ⟨10.1111/fcp.12657⟩
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2021, ⟨10.1111/fcp.12657⟩

International audience; Organic cation transporter (OCT) 3 (SLC22A3) is a widely-expressed drug transporter, handling notably metformin and platinum derivatives, as well as endogenous compounds like monoamine neurotransmitters. OCT3 has been shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fd25b777376f878e4ebcd7c3dba866
https://hal.science/hal-03134613

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Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study

Autor: Olivier Le Marec, Nicolas Chartrel, Jean A. Boutin, Hubert Vaudry, Jérôme Leprince, Christophe Dubessy, Cindy Neveu, Karima Alim, Marie Christine Picot, David Vaudry, Julien Chuquet, Benjamin Lefranc, Gaëtan Prévost

Publikováno v: Molecules
Molecules, MDPI, 2021, 26 (14), pp.4312. ⟨10.3390/molecules26144312⟩
Molecules, Vol 26, Iss 4312, p 4312 (2021)
Volume 26
Issue 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de55e4482c5d8bff6d95294645479664
https://doi.org/10.3390/molecules26144312

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Akademický článek

Selection of doubled haploid black rice lines in advanced yield trial based on multivariate analysis.

Autor: KARIMA, ALIM WULANDARI, PUTRI, RATNA KARTIKA, PURWOKO, BAMBANG SAPTA, DEWI, ISWARI SARASWATI, SUWARNO, WILLY BAYUARDI, KURNIAWATI, ANI

Publikováno v: Biodiversitas: Journal of Biological Diversity; Dec2021, Vol. 22 Issue 12, p5425-5431, 7p

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Design, Synthesis, Molecular Dynamics Simulation, and Functional Evaluation of a Novel Series of 26RFa Peptide Analogues Containing a Mono- or Polyalkyl Guanidino Arginine Derivative

Autor: Jérôme Leprince, Jana Sopkova-de Oliveira Santos, Marie Christine Picot, Benjamin Lefranc, Hubert Vaudry, Christophe Dubessy, Jean A. Boutin, David Vaudry, Nicolas Chartrel, Julien Chuquet, Karima Alim

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (22), pp.10185-10197. ⟨10.1021/acs.jmedchem.8b01332⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, ⟨10.1021/acs.jmedchem.8b01332⟩

International audience; 26RFa, the endogenous QRFPR ligand, is implicated in several physiological and pathological conditions such as the regulation of glucose homeostasis and bone mineralization; hence, QRFPR ligands display therapeutic potential.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3db9abfd3d47d89fd19afcb23d93bc
https://hal-normandie-univ.archives-ouvertes.fr/hal-02330453

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Masked Selection: A Straightforward and Flexible Approach for the Selection of Binders Against Specific Epitopes and Differentially Expressed Proteins by Phage Display

Autor: Brigitte Kerfelec, Karima Alim, Stéphane Audebert, Marie Noelle Lavaut, Daniel Baty, Damien Nevoltris, Klervi Even-Desrumeaux, Patrick Chames, Jean-Paul Borg

Publikováno v: Molecular and Cellular Proteomics
Molecular and Cellular Proteomics, 2014, 13 (2), pp.653-665. ⟨10.1074/mcp.O112.025486⟩
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2014, 13 (2), pp.653-665. ⟨10.1074/mcp.O112.025486⟩
Molecular & Cellular Proteomics

Phage display is a well-established procedure to isolate binders against a wide variety of antigens that can be performed on purified antigens, but also on intact cells. As selection steps are performed in vitro, it is possible to focus the outcome o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee44a150eb419c19aacc492f545b7eb8
https://doi.org/10.1074/mcp.o112.025486

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