Výsledky vyhledávání - "Karim S. Shalaby"

Cyclodextrin Complex Formation with Water-Soluble Drugs: Conclusions from Isothermal Titration Calorimetry and Molecular Modeling

Autor: Karim S. Shalaby, Alf Lamprecht, Muhammad I. Ismail

Publikováno v: AAPS PharmSciTech

Cyclodextrin (CD) complexes are frequently used for enhancing the solubility or absorption of poorly water-soluble drugs. On the contrary, little is known about their complex formation with water-soluble drugs. Here, we have studied the interaction b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8176f6eb3bbadb07200ae8eb05700750
https://doi.org/10.1208/s12249-021-02040-8

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Drug delivery to the inflamed intestinal mucosa – targeting technologies and human cell culture models for better therapies of IBD

Autor: Karim S. Shalaby, Maryam A. Shetab Boushehri, Brigitta Loretz, Alf Lamprecht, Claus-Michael Lehr, Olga Hartwig

Publikováno v: Advanced Drug Delivery Reviews. 175:113828

Current treatment strategies for inflammatory bowel disease (IBD) seek to alleviate the undesirable symptoms of the disorder. Despite the higher specificity of newer generation therapeutics, e.g. monoclonal antibodies, adverse effects still arise fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5306b77f25301bc7e8c1f08cd12b3655
https://doi.org/10.1016/j.addr.2021.113828

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Optimization of Melatonin Dissolution from Extended Release Matrices Using Artificial Neural Networking

Autor: D. Martarelli, Laura Fagioli, Giovanni Filippo Palmieri, Karim S. Shalaby, Marco Cespi, Diego Romano Perinelli, Mahmoud E. S. Soliman, Jenny K.W. Lam, Giulia Bonacucina, Luca Casettari

Publikováno v: Scopus-Elsevier

Background: Efficacy of melatonin in treating sleep disorders has been demonstrated in numerous studies. Being with short half-life, melatonin needs to be formulated in extended-release tablets to prevent the fast drop of its plasma concentration. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f48af035efe7e6a4a78f2274042ae0a
http://www.eurekaselect.com/132072/article

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Nanoparticles Based on Linear and Star-Shaped Poly(Ethylene Glycol)-Poly(ε-Caprolactone) Copolymers for the Delivery of Antitubulin Drug

Autor: Mahmoud E. S. Soliman, Giulia Bonacucina, Omaima A. Sammour, Lisbeth Illum, Giovanni Filippo Palmieri, Abdelhameed A. El Shamy, Karim S. Shalaby, Marco Cespi, Luca Casettari

Biodegradable polymeric nanoparticles of different architectures based on polyethylene glycol-co-poly(ε-caprolactone) block copolymers have been loaded with noscapine (NOS) to study their effect on its anticancer activity. It was intended to use sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d95d964a00bb70ea5aec495bd9ef99
https://hdl.handle.net/11576/2637832

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Determination of factors controlling the particle size and entrapment efficiency of noscapine in PEG/PLA nanoparticles using artificial neural networks

Autor: Giovanni Filippo Palmieri, Mahmoud E. S. Soliman, Karim S. Shalaby, Luca Casettari, Omaima A. Sammour, Giulia Bonacucina, Marco Cespi, Abdelhameed A. El Shamy

Publikováno v: International Journal of Nanomedicine

Karim S Shalaby,1 Mahmoud E Soliman,1 Luca Casettari,2 Giulia Bonacucina,3 Marco Cespi,3 Giovanni F Palmieri,3 Omaima A Sammour,1 Abdelhameed A El Shamy1,† 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams Univers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c42b2531b1bc8f2cb5d68535539eff3
https://doi.org/10.2147/ijn.s68737

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