Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Karim Rafie"'
Autor:
Sabine Bartel, Justina C. Wolters, Hasnat Noor, Karim Rafie, Jiahua Fang, Benedikt Kirchner, Esther Nolte-′t Hoen, Michael W. Pfaffl, Steven Rutgers, Wim Timens, Maarten van den Berge, Machteld N. Hylkema
Publikováno v:
Cells, Vol 13, Iss 11, p 945 (2024)
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease for which there is no cure. Accumulating research results suggest a role for extracellular vesicles (EVs) in the pathogenesis of COPD. This study aimed to uncover the involvem
Externí odkaz:
https://doaj.org/article/17a0e1b40c69407f9b113d33e5cde8e4
Autor:
Karim Rafie, Olawale Raimi, Andrew T. Ferenbach, Vladimir S. Borodkin, Vaibhav Kapuria, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 7, Iss 6 (2017)
O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-translational modification found on hundreds of nucleocytoplasmic proteins in metazoa. Although a single enzyme, O-GlcNAc transferase (OGT), generates the entire cytosolic O-Glc
Externí odkaz:
https://doaj.org/article/21a9f124fabb4a7cbe3a2df051cdbdb9
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence
Autor:
Shalini Pathak, Jana Alonso, Marianne Schimpl, Karim Rafie, David E. Blair, Vladimir S. Borodkin, Alexander W. Schüttelkopf, Osama Albarbarawi, Daan M. F. van Aalten
Publikováno v:
Nature Structural & Molecular Biology. 30:564-564
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913f22de9d5642f2f5b11375c4e08651
https://doi.org/10.1038/s41594-023-00945-5
https://doi.org/10.1038/s41594-023-00945-5
Autor:
Pravin Kumar, Erin Schexnaydre, Karim Rafie, Tatsuaki Kurata, Ilya Terenin, Vasili Hauryliuk, Lars‐Anders Carlson
Nonstructural protein 1 (Nsp1) of SARS-CoV-2 inhibits host cell translation through an interaction between its C-terminal domain and the 40S ribosome. The N-terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22feadf284a199650c786dee5527cb1
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194639
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194639
Autor:
Pravin Kumar, Vasili Hauryliuk, Erin Schexnaydre, Lars-Anders Carlson, Karim Rafie, Ilya M. Terenin
SummaryNonstructural protein 1 (Nsp1) is a major pathogenicity factor of SARS-CoV-2. It inhibits host-cell translation, primarily through a direct interaction between its C-terminal domain and the mRNA entry channel of the 40S small ribosomal subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a6ac48a1612c5cb5701c6fb1feac0c
https://doi.org/10.1101/2021.11.03.467065
https://doi.org/10.1101/2021.11.03.467065
Autor:
Katja Mindler, Lijo John, Lars-Anders Carlson, B. David Persson, Michael Strebl, Menzo J. E. Havenga, Niklas Arnberg, Angelique A. C. Lemckert, Mónika Z. Ballmann, Lars Frängsmyr, Thilo Stehle, Karim Rafie
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The adenovirus capsid protein is built by three main capsomers: hexon, fiber, and penton base. Entry is mediated by fiber proteins anchoring the virus to host cell receptors and is followed by penton base proteins engaging coreceptors, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c566e2b86cd499131e5a7ab0025cb449
http://europepmc.org/articles/PMC7826407
http://europepmc.org/articles/PMC7826407
Autor:
Karim Rafie, Anandi Rajan, Niklas Arnberg, Annasara Lenman, Lars-Anders Carlson, Johannes Fuchs
Publikováno v:
Science advances
United States
Science Advances
United States
Science Advances
A cryo-EM structure reveals unique traits of a human adenovirus that has acquired gastrointestinal tropism.
Human adenovirus (HAdV) types F40 and F41 are a prominent cause of diarrhea and diarrhea-associated mortality in young children worldwide
Human adenovirus (HAdV) types F40 and F41 are a prominent cause of diarrhea and diarrhea-associated mortality in young children worldwide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f315078238b72178a8e56a652e1fe070
https://doi.org/10.1101/2020.07.01.181735
https://doi.org/10.1101/2020.07.01.181735
Autor:
Daan M. F. van Aalten, Nithya Selvan, Tonia Aristotelous, Vladimir S. Borodkin, Iva Navratilova, Andrew T. Ferenbach, Karim Rafie
Publikováno v:
ACS Chem Biol
The attachment of the sugar N-acetyl-D-glucosamine (GlcNAc) to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation. O-GlcNAc transferase (OGT) is the enzyme responsible for carrying out the modification, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ea27df4c64341f613fcd026d838950
https://doi.org/10.1021/acschembio.8b00183
https://doi.org/10.1021/acschembio.8b00183
Autor:
David Sádaba, Daan M. F. van Aalten, Elena Marchesi, Pedro Merino, Mattia Ghirardello, Marco Fogagnolo, Tomás Tejero, Karim Rafie, Daniela Perrone, J. Ignacio Delso, Nicola Chinaglia
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
A series of glycomimetics of UDP-GlcNAc, in which the β-phosphate has been replaced by either an alkyl chain or a triazolyl ring and the sugar moiety has been replaced by a pyrrolidine ring, has been synthesized by the application of different click
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7946565f6599d111a7ff18cff4a9785a
https://pubmed.ncbi.nlm.nih.gov/29513364
https://pubmed.ncbi.nlm.nih.gov/29513364
Autor:
Axel Knebel, Kuan-Chuan Pao, Kay Hofmann, Peter D. Mabbitt, Satpal Virdee, Karim Rafie, Ramasubramanian Sundaramoorthy, Daan M. F. van Aalten, Nicola T. Wood, Mathew Stanley
Publikováno v:
Nature. 556(7701)
Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1) to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2–Ub)1. Ubiquitin ligases (E3s) of the ‘really interesting new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844a6e68f3899c99a0900ec35c9cb64c
https://pubmed.ncbi.nlm.nih.gov/29643511
https://pubmed.ncbi.nlm.nih.gov/29643511