Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Karim Pirani"'
Autor:
Weiya Liu, Benjamin L Woolbright, Karim Pirani, Ryan Didde, Erika Abbott, Gaurav Kaushik, Paige Martin, Jill Hamilton-Reeves, John A Taylor, Jeffrey M Holzbeierlein, Shrikant Anant, Eugene K Lee
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218737 (2019)
PurposeBladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between an active tetramer and an inactive dimer. We aim to further characterize PKM2, in p
Externí odkaz:
https://doaj.org/article/8ff889ab6a87485e8cc417e642e9b833
Autor:
Rachel Zufferey, Karim Pirani, Melanie Cheung-See-Kit, Sungsu Lee, Tyler A Williams, Daniel G Chen, Md Faruk Hossain
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181432 (2017)
Glycerophospholipids are the most abundant constituents of biological membranes in Trypanosoma brucei, which causes sleeping sickness in humans and nagana in cattle. They are essential cellular components that fulfill various important functions beyo
Externí odkaz:
https://doaj.org/article/a3b2b8158f40414db925de93dfe97793
Autor:
Roger Gaedigk, Rachel W. Chevalier, Karim Pirani, Valentina Shakhnovich, Janelle R Noel-Macdonnell PhD
Publikováno v:
Gastroenterology. 160:S-40
Autor:
Eugene K. Lee, Gaurav Kaushik, Benjamin L. Woolbright, Jeffrey M. Holzbeierlein, Jill Hamilton-Reeves, John A. Taylor, Erika Abbott, Paige Martin, Ryan Didde, Shrikant Anant, Weiya Liu, Karim Pirani
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218737 (2019)
PLoS ONE
PLoS ONE
PurposeBladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between an active tetramer and an inactive dimer. We aim to further characterize PKM2, in p
Autor:
Jeffrey M. Holzbeierlein, Gaurav Kaushik, Eugene K. Lee, Weiya Liu, Ryan Didde, Benjamin L. Woolbright, Karim Pirani, Shrikant Anant, Erika Abbott, John A. Taylor
Publikováno v:
Journal of Clinical Oncology. 37:410-410
410 Background: Bladder cancer remains the fourth most common cancer in American males with a higher risk of recurrence and progression for patients with diabetes mellitus. Urothelial bladder cancer is characterized by aerobic glycolysis with upregul
Publikováno v:
Journal of Clinical Oncology. 35:416-416
416 Background: Hsp90 represents one of the most promising biological targets for the treatment of cancer, including bladder cancer. A number of Hsp90 inhibitors that target the N-terminal ATP-binding pocket have demonstrated potent antiproliferative
Autor:
Karim Pirani, Paige Martin, Jeffrey M. Holzbeierlein, Parthasarathy Rangarajan, Jill Hamilton-Reeves, Eugene K. Lee, Shrikant Anant
Publikováno v:
Journal of Clinical Oncology. 35:359-359
359 Background: To understand and evaluate the role of glucose metabolism in bladder cancer growth, in the identification of disease, and development of potential treatment strategies. Methods: UMUC3, T24 and 253JBV cells were grown in varying glucos