Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Karim Malki"'
Publikováno v:
Neurobiology of Aging. 86:39-53
Alzheimer's disease (AD) is a currently incurable neurodegenerative disorder. Several genetic studies have identified a rare variant of triggering receptor expressed on myeloid cells 2 (TREM2) as a risk factor for AD. TREM2 is thought to trigger the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d672b4767a3045750b869ea21f02a0
https://doi.org/10.1016/j.neurobiolaging.2019.09.004
https://doi.org/10.1016/j.neurobiolaging.2019.09.004
Autor:
Michael J. O'Neill, David A. Collier, Alan Hodgkinson, Richard Dobson, Guillermo Carbajosa, Eva Wozniak, Hong Wang, Nathan Lawless, Angela Hodges, Stephen Newhouse, John W. Ryder, Kristie Wood, Karim Malki, Charles A. Mein
A microglia response to pathogenic signals in diseases such as Alzheimer’s disease (AD) has long been recognised, but recent genetic findings have cemented their direct causal contribution to AD and thus the potential to target them or their effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8f3b1fabf1d01baebb27a64970fc96
https://doi.org/10.1101/2021.07.16.452732
https://doi.org/10.1101/2021.07.16.452732
Autor:
Karim Malki, Fiona M. Boissonade, Diana Tavares-Ferreira, Emma V. Bird, Simon Atkins, Daniel W. Lambert, Emanuele Sher, Nathan Lawless, David A. Collier
Publikováno v:
Molecular Pain
Background\ud Peripheral nerve injury causes changes in expression of multiple receptors and mediators that participate in pain processing. We investigated the expression of microRNAs (miRNAs) – a class of post-transcriptional regulators involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6592e1913089134a18438803e2dbba4c
https://pubmed.ncbi.nlm.nih.gov/31218919
https://pubmed.ncbi.nlm.nih.gov/31218919
Autor:
Joe Burrage, Leonard C. Schalkwyk, Eilis Hannon, Meena Kumari, T.J. Gorrie-Stone, Karim Malki, Jonathan Mill, Ayden Saffari, Melissa C. Smart
Publikováno v:
Gorrie-Stone, T J, Smart, M C, Saffari, A, Malki, K, Hannon, E, Burrage, J, Mill, J, Kumari, M & Schalkwyk, L C 2019, ' Bigmelon : Tools for analysing large DNA methylation datasets ', BIOINFORMATICS, vol. 35, no. 6, pp. 981-986 . https://doi.org/10.1093/bioinformatics/bty713
Bioinformatics
Bioinformatics
Motivation The datasets generated by DNA methylation analyses are getting bigger. With the release of the HumanMethylationEPIC micro-array and datasets containing thousands of samples, analyses of these large datasets using R are becoming impractical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1498dde192a3d70bc4c76cb89bafb2
https://kclpure.kcl.ac.uk/ws/files/123171258/bty713.pdf
https://kclpure.kcl.ac.uk/ws/files/123171258/bty713.pdf
Autor:
Carla S. Möller-Levet, Harriet Hicks, Nathan Lawless, Andrew McCarthy, Derk-Jan Dijk, Keith A. Wafford, Raphaelle Winsky-Sommerer, Huihai Wu, Emma Laing, Karim Malki, Mathieu Nollet
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Sleep disturbances are common in stress-related disorders but the nature of these sleep disturbances and how they relate to changes in the stress hormone corticosterone and changes in gene expression remained unknown. Here we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e83d0d1895e5af2f7f7120d75cfdf21
https://pubmed.ncbi.nlm.nih.gov/30683720
https://pubmed.ncbi.nlm.nih.gov/30683720
Autor:
Oliver Pain, Philip Asherson, Ebba Du Rietz, Sietse F. de Boer, Leonard C. Schalkwyk, Karim Malki, Rezhaw L. Karadaghi, Jose L. Paya-Cano, Maria Grazia Tosto, Frans Sluyter, Kenneth Sandnabba, Wim E. Crusio
Publikováno v:
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 171(6), 827-838. Wiley
Despite moderate heritability estimates, the molecular architecture of aggressive behavior remains poorly characterized. This study compared gene expression profiles from a genetic mouse model of aggression with Zebrafish, an animal model traditional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6512bb397b71dd41b7262d290398211c
https://research.rug.nl/en/publications/040b99cc-144b-4356-b631-ce95e37e6389
https://research.rug.nl/en/publications/040b99cc-144b-4356-b631-ce95e37e6389
Publikováno v:
Annals of the New York Academy of Sciences. 1366:61-75
The spectacular advance in our understanding of the genetic basis of schizophrenia through genome-wide association studies has the potential to identify new leads for drug treatment through improved understanding of disease pathophysiology. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::224af64f0a11520dff80d376418b506f
https://doi.org/10.1111/nyas.13066
https://doi.org/10.1111/nyas.13066
Autor:
Emma Laing, Nathan Lawless, Mathieu Nollet, Andrew McCarthy, Harriet Hicks, Karim Malki, Raphaelle Winsky-Sommerer, Huihai Wu, Carla S. Möller-Levet, Keith A. Wafford, Derk-Jan Dijk
One of sleep’s putative functions is mediation of adaptation to waking experiences. Chronic stress is a common waking experience, however, which specific aspect of sleep is most responsive, and how sleep changes relate to behavioral disturbances an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47d9c44faa5832a09876d2c58e3149c
Autor:
Guillermo Carbajosa, Nathan Lawless, Eva Wozniak, Karim Malki, Angela Hodges, Richard Dobson, Kristie Wood, Stephen Newhouse, Hong Wang, John W. Ryder, Michael J. O'Neill, David A. Collier, Charles A. Mein
Publikováno v:
Carbajosa, G, Malki, K, Lawless, N, Wang, H, Ryder, J W, Wozniak, E, Wood, K, Mein, C A, Dobson, R J B, Collier, D A, O'Neill, M J, Hodges, A K & Newhouse, S J 2018, ' Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain ', Neurobiology of Aging, vol. 69, pp. 151-166 . https://doi.org/10.1016/j.neurobiolaging.2018.04.019
Rare heterozygous coding variants in the Triggering Receptor Expressed in Myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified. We examined the transcriptional consequences of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ee80debee5a3d95c02ee277c9de126
https://kclpure.kcl.ac.uk/ws/files/101828997/Loss_of_Trem2_in_Carbajosa_2018_GOLD_VoR.pdf
https://kclpure.kcl.ac.uk/ws/files/101828997/Loss_of_Trem2_in_Carbajosa_2018_GOLD_VoR.pdf
Autor:
Katherine J. Aitchison, Daniel Souery, Rudolf Uher, Mojca Z. Dernovsek, Karim Malki, Joanna Hauser, Peter McGuffin, Marcella Rietschel, Anne Farmer, Ole Mors, Raquel Iniesta, Wolfgang Maier, Richard Dobson, Neven Henigsberg, Karen Hodgson, Cathryn M. Lewis, Daniel Stahl
Publikováno v:
Scientific reports, 8 (1
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Iniesta, R, Hodgson, K, Stahl, D, Malki, K, Maier, W, Rietschel, M, Mors, O, Hauser, J, Henigsberg, N, Dernovsek, M Z, Souery, D, Dobson, R, Aitchison, K J, Farmer, A, McGuffin, P, Lewis, C M & Uher, R 2018, ' Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables ', Scientific Reports, vol. 8, no. 1, 5530 . https://doi.org/10.1038/s41598-018-23584-z
Scientific Reports
Iniesta, R, Hodgson, K, Stahl, D R, Malki, K, Maier, W, Rietschel, M, Mors, O, Hauser, J, Henigsberg, N, Dernovšek, M Z, Souery, D, Dobson, R, Aitchison, K J, Farmer, A, McGuffin, P, Lewis, C M & Uher, R 2018, ' Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables ', Scientific Reports, vol. 8, no. 1, 5530 . https://doi.org/10.1038/s41598-018-23584-z
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Iniesta, R, Hodgson, K, Stahl, D, Malki, K, Maier, W, Rietschel, M, Mors, O, Hauser, J, Henigsberg, N, Dernovsek, M Z, Souery, D, Dobson, R, Aitchison, K J, Farmer, A, McGuffin, P, Lewis, C M & Uher, R 2018, ' Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables ', Scientific Reports, vol. 8, no. 1, 5530 . https://doi.org/10.1038/s41598-018-23584-z
Scientific Reports
Iniesta, R, Hodgson, K, Stahl, D R, Malki, K, Maier, W, Rietschel, M, Mors, O, Hauser, J, Henigsberg, N, Dernovšek, M Z, Souery, D, Dobson, R, Aitchison, K J, Farmer, A, McGuffin, P, Lewis, C M & Uher, R 2018, ' Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables ', Scientific Reports, vol. 8, no. 1, 5530 . https://doi.org/10.1038/s41598-018-23584-z
Individuals with depression differ substantially in their response to treatment with antidepressants. Specific predictors explain only a small proportion of these differences. To meaningfully predict who will respond to which antidepressant, it may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387597b77adccce745590659cbc5c7c1
https://doi.org/10.1038/s41598-018-23584-z
https://doi.org/10.1038/s41598-018-23584-z