Výsledky vyhledávání - "Karim Kaabeche"

Down-Regulation of Ubiquitin Ligase Cbl Induced by Twist Haploinsufficiency in Saethre-Chotzen Syndrome Results in Increased PI3K/Akt Signaling and Osteoblast Proliferation

Autor: Hichem Miraoui, Pierre J. Marie, Hind Guenou, Karim Kaabeche, Cécilie Dufour

Publikováno v: The American Journal of Pathology. 169:1303-1311

Genetic mutations of Twist, a basic helix-loop-helix transcription factor, induce premature fusion of cranial sutures in Saethre-Chotzen syndrome (SCS). We report here a previously undescribed mechanism involved in the altered osteoblastogenesis in S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61011ded48ab799f1b5b9c260e512d99
https://doi.org/10.2353/ajpath.2006.060102

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PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading

Autor: Karim Kaabeche, P. J. Marie

Publikováno v: PPAR Research, Vol 2006 (2006)
PPAR Research

Bone loss occuring with unloading is associated with decreased osteoblastogenesis and increased bone marrow adipogenesis, resulting in bone loss and decreased bone formation. Here, we review the present knowledge on the role of PPARγin the control o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b51aefbc8ca23b6dbb495fd9a0fdef
https://doi.org/10.1155/ppar/2006/64807

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Cbl-mediated Degradation of Lyn and Fyn Induced by Constitutive Fibroblast Growth Factor Receptor-2 Activation Supports Osteoblast Differentiation

Autor: Joseph Caverzasio, Karim Kaabeche, Sandrine Le Mée, Jérome Lemonnier, Pierre J. Marie

Publikováno v: Journal of Biological Chemistry. 279:36259-36267

Fibroblast growth factors (FGFs) play an important regulatory role in skeletal development and bone formation. However, the FGF signaling mechanisms controlling osteoblast function are poorly understood. Here, we identified a role for the Src family

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7a8f72349052ec00311eef224b16dc
https://doi.org/10.1074/jbc.m402469200

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FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival

Autor: Archana Sanjay, Pierre J. Marie, Hind Guenou, Cécilie Dufour, Daniel Bouvard, Karim Kaabeche

Publikováno v: BONE
BONE, Elsevier, 2008, 42 (6), pp.1032-9. ⟨10.1016/j.bone.2008.02.009⟩
BONE, 2008, 42 (6), pp.1032-9. ⟨10.1016/j.bone.2008.02.009⟩

International audience; Fibroblast growth factor receptor (FGFR) signaling plays an important role in skeletogenesis. The molecular mechanisms triggered by activated FGFR in bone forming cells are however not fully understood. In this study, we ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baebb583dad90f441a8ae9dfed7522fc
https://www.hal.inserm.fr/inserm-00346884

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Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts

Autor: Pierre J, Marie, Karim, Kaabeche, Hind, Guenou

Publikováno v: Frontiers of oral biology. 12

Recent advances in molecular genetics have led to a better understanding of the role of specific genes such as fibroblast growth factor receptor (FGFR) and Twist in cranial bone formation. Specifically, the analysis of osteoblast abnormalities induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1065b18925af6ae87c6a6d18577be2c6
https://pubmed.ncbi.nlm.nih.gov/18391499

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Roles of FGFR2 and Twist in Human Craniosynostosis: Insights from Genetic Mutations in Cranial Osteoblasts

Autor: Karim Kaabeche, Pierre J. Marie, Hind Guenou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be1804e240accc08c89557971d25377d
https://doi.org/10.1159/000115036

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A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome

Autor: Sandrine Le Mée, Karim Kaabeche, Pierre J. Marie, Hind Guenou

Publikováno v: Human molecular genetics. 14(11)

Genetic mutations of Twist, a bHLH transcription factor, induce premature fusion of cranial sutures (craniosynostosis) in the Saethre-Chotzen syndrome (SCS). The mechanisms by which Twist haploinsufficiency may alter osteoblast differentiation are po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4777b2f4fc18a446f2926cfaeba391a
https://pubmed.ncbi.nlm.nih.gov/15829502

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Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation

Autor: Pierre J. Marie, Hind Guenou, Nadège Didelot, Karim Kaabeche, Daniel Bouvard, Antoine Listrat

Publikováno v: Journal of cell science. 118(Pt 6)

Fibroblast growth factor receptor signaling is an important mechanism regulating osteoblast function. To gain an insight into the regulatory role of FGF receptor-2 (FGFR2) signaling in osteoblasts, we investigated integrin-mediated attachment and cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3c4ac214b6d80483df2bd7a97bdb47
https://pubmed.ncbi.nlm.nih.gov/15728256

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