Výsledky vyhledávání - "Karim El-Haschimi"

Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S6 Kinase 2

Autor: Karim El-Haschimi, Michael F. Hirshman, Jeffrey S. Flier, Scott D. Dufresne, Laurie J. Goodyear, Christian Bjørbæk

Publikováno v: Diabetes. 52:1340-1346

The p90 ribosomal S6 kinase 2 (RSK2) is a serine/threonine kinase with high expression levels in adipose tissue. Numerous in vitro studies show that RSK2 is activated by a broad number of cellular stimuli and suggest that RSK2 is involved in the regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6d725bee3081db2b61ed75dffb9bfc
https://doi.org/10.2337/diabetes.52.6.1340

Zobrazit plný text záznamu

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

Autor: Stanley M. Hileman, Jeffrey S. Flier, Karim El-Haschimi, Christian Bjørbæk, Dominique D. Pierroz

Publikováno v: Journal of Clinical Investigation. 105:1827-1832

Obesity in humans and in rodents is usually associated with high circulating leptin levels and leptin resistance. To examine the molecular basis for leptin resistance, we determined the ability of leptin to induce hypothalamic STAT3 (signal transduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a54794a3fe1254b90f859598b9cf100
https://doi.org/10.1172/jci9842

Zobrazit plný text záznamu

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance

Autor: J D Frantz, Christian Bjørbæk, Jeffrey S. Flier, Karim El-Haschimi

Publikováno v: Journal of Biological Chemistry. 274:30059-30065

We earlier demonstrated that leptin induces expression of SOCS-3 mRNA in the hypothalamus. Furthermore, transfection data suggest that SOCS-3 is an inhibitor of leptin signaling. However, little is known about the regulation of SOCS-3 expression by l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d7f33d8f14f3938f5a6cc99eb74b85
https://doi.org/10.1074/jbc.274.42.30059

Zobrazit plný text záznamu

Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor1

Autor: Joseph Kelly, Joel K. Elmquist, Stanley M. Hileman, Jeffrey S. Flier, Christian Bjørbæk, Karim El-Haschimi, Rexford S. Ahima

Publikováno v: Endocrinology. 140:2035-2043

Ciliary neurotrophic factor (CNTF) is a neurocytokine expressed in glial cells that acts on brain cells to promote gene expression, survival, and differentiation. When administered systemically, CNTF reduces food intake and body weight in rodents. Ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::229c1733d359dc5a0a07ab08edbb0dbd
https://doi.org/10.1210/endo.140.5.6736

Zobrazit plný text záznamu

CV-11974, the active metabolite of TCV-116 (candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells

Autor: Karim El-Haschimi, Hans Vetter, Claudia Seul, Yon Ko, Rainer Düsing, Agapios Sachinidis

Publikováno v: Biochemical Pharmacology. 52:123-126

Many previous studies have demonstrated that angiotensin II (AII) type 1 (AT1) receptor antagonists remarkably reduced intimal lesions in rats following balloon injury. Using vascular smooth muscle cells (VSMC) in culture, we tested the hypothesis th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6896de6f6e5cf793323541fbd31c79
https://doi.org/10.1016/0006-2952(96)00171-2

Zobrazit plný text záznamu

Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice

Autor: Giuseppe Matarese, Terry B. Strom, Karim El-Haschimi, Elizabeth Papathanassoglou, Christos S. Mantzoros, Xian Chang Li

Publikováno v: The Journal of immunology (1950) 176 (2006): 7745–7752.
info:cnr-pdr/source/autori:Papathanassoglou E, El-Haschimi K, Chang Li X, Matarese G, Strom T, Mantzoros C./titolo:Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice./doi:/rivista:The Journal of immunology (1950)/anno:2006/pagina_da:7745/pagina_a:7752/intervallo_pagine:7745–7752/volume:176
Scopus-Elsevier

Leptin has direct effects not only on neuroendocrine function and metabolism, but also on T cell-mediated immunity. We report in this study that leptin receptor (ObR) is expressed on resting normal mouse CD4+, CD8+, B cells, and monocyte/macrophages.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0404fea25f9385fd12fd629ca9f6db31
https://hdl.handle.net/20.500.14279/1903

Zobrazit plný text záznamu

Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity

Autor: Jeffrey S. Flier, Hiroaki Masuzaki, William A. Banks, Dominique D. Pierroz, Karim El-Haschimi, Stanley M. Hileman, Christian Bjørbæk

Publikováno v: Endocrinology. 143(3)

Leptin deficiency causes obesity in rodents and humans, but circulating levels of leptin are paradoxically elevated in obesity. The mechanisms underlying this leptin resistance are unknown, but may involve reduced leptin transport across the blood-br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a5a70257efb3beb1a4beac5c516d4e
https://pubmed.ncbi.nlm.nih.gov/11861497

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání