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Akademický článek

Histamine Produced by Gram-Negative Bacteria Impairs Neutrophil’s Antimicrobial Response by Engaging the Histamine 2 Receptor

Autor: Karim Dib, Amal El Banna, Clara Radulescu, Guillermo Lopez Campos, Gerard Sheehan, Kevin Kavanagh

Publikováno v: Journal of Innate Immunity, Pp 1-21 (2022)

We found that histamine (10−9 M) did not have any effect on the in vitro capture of Escherichia coli by neutrophils but accelerated its intracellular killing. In contrast, histamine (10−6 M) delayed the capture of Escherichia coli by neutrophils

Externí odkaz: https://doaj.org/article/8be7ffe52fce435a9c89ea525e9aec34

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The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif

Autor: Karim Dib, Aleksandar Ivetic, Irina G. Tikhonova, Peter Schu

Publikováno v: Dib, K, Tikhonova, I G, Ivetic, A & Schu, P 2017, ' The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif. ', Journal of Biological Chemistry, pp. 6703-6714 . https://doi.org/10.1074/jbc.M116.768598
Dib, K, Tikhonova, I G, Ivetic, A & Schu, P 2017, ' The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit mu1A via a novel basic binding motif ', The Journal of Biological Chemistry, vol. 292, no. 16, pp. 6703-6714 . https://doi.org/10.1074/jbc.M116.768598

L-selectin regulates leukocyte adhesion and rolling along the endothelium. Proteins binding to the cytoplasmic tail of L-selectin regulate L-selectin functions. We used L-selectin cytoplasmic tail peptide pulldown assays combined with high sensitivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a78c7e504d7bb59b0a257cf98ab9c7
https://pubmed.ncbi.nlm.nih.gov/28235798

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Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets

Autor: Peter M, Benz, Hebatullah, Laban, Joana, Zink, Lea, Günther, Ulrich, Walter, Stepan, Gambaryan, Karim, Dib

Publikováno v: Cell Communication and Signaling : CCS

Background Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. αIIbβ3 is the main integrin responsible for plat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41a04895c5a0270f3a03334153bac6ad
https://pubmed.ncbi.nlm.nih.gov/27620165

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Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1

Autor: Ravi K. Deevi, Cheryl McFarlane, Madhuri Dash-Koney, Karim Dib

Publikováno v: Journal of Leukocyte Biology. 90:741-749

Epac1 and Epac2 bind cAMP and mediate cAMP-dependent activation of Rap1. cAMP is produced in neutrophils in response to many chemoattractants. This second messenger plays a key role in the regulation of the functions of neutrophils. However, it is st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8940039312bf760392123f54b9bcb9db
https://doi.org/10.1189/jlb.0211108

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USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

Autor: James F. Burrows, Cheryl McFarlane, Ureshnie Govender, Michael J. McGrattan, James A. Johnston, Michelle de la Vega, Alyson A. Kelvin, Derek J. Quinn, Roberta E. Burden, Karim Dib, Christopher J. Scott, Massimo Gadina

Publikováno v: Journal of Biological Chemistry. 284:9587-9595

The proto-oncogene Ras undergoes a series of post-translational modifications at its carboxyl-terminal CAAX motif that are essential for its proper membrane localization and function. One step in this process is the cleavage of the CAAX motif by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bb4030980d8ff4b188dfd9dbabb1ee
https://doi.org/10.1074/jbc.m807216200

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Nitric Oxide Produced in Response to Engagement of β2 Integrins on Human Neutrophils Activates the Monomeric GTPases Rap1 and Rap2 and Promotes Adhesion

Autor: Tommy Andersson, Karim Dib, Lena Axelsson, Catherine Adams, Veronika Jenei, Ravi K. Deevi, David G. Hirst

Publikováno v: Journal of Biological Chemistry. 281:35008-35020

We found that engagement of beta2 integrins on human neutrophils increased the levels of GTP-bound Rap1 and Rap2. Also, the activation of Rap1 was blocked by PP1, SU6656, LY294002, GF109203X, or BAPTA-AM, which indicates that the downstream signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef344eeded8957b4172916f348eff54
https://doi.org/10.1074/jbc.m601335200

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E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor

Autor: Karim Dib, Judit Jakus, Tommy Andersson, Veronika Jenei

Publikováno v: Experimental Cell Research. 310:463-473

E3B1, a human homologue of the mouse gene product Abi-1, has been implicated in growth-factor-mediated regulation of the small GTPases p21(Ras) and Rac. E3b1 is a regulator of Rac because it can form a complex with Sos-1 and eps8, and such a Sos-1-e3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cd9371787c7d2d75b585dbdb4989dd
https://doi.org/10.1016/j.yexcr.2005.08.010

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Fgr but not Syk tyrosine kinase is a target for beta2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils

Autor: Karim Dib, Tommy Andersson, Fredrik Melander

Publikováno v: Biochemical Journal. 370:687-694

An early and critical event in beta(2) integrin signalling during neutrophil adhesion is activation of Src tyrosine kinases and Syk. In the present study, we report Src kinase-dependent beta(2) integrin-induced tyrosine phosphorylation of Cbl occurri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51fd221031b64a8bc53438040a168e4
https://doi.org/10.1042/bj20021201

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Cyclic AMP Regulation of Giα2 and Giα3 mRNAs and Proteins in Astroglial Cells

Autor: Amina El Jamali, C. Correze, Karim Dib, Nadia Rachdaoui

Publikováno v: Journal of Neurochemistry. 71:2271-2277

Culture of rat astrocytes in the presence of 10 microM forskolin, isoproterenol, a nonselective beta-adrenergic agonist, or 8-bromo-cyclic AMP increased transiently in a time-dependent manner the levels of G(i alpha2) and G(i alpha3) mRNAs as measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53d7d9f3a1eb384fcd182388f3e1adca
https://doi.org/10.1046/j.1471-4159.1998.71062271.x

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Wnt-5a and G-protein signaling are required for collagen-induced DDR1 receptor activation and normal mammary cell adhesion

Autor: Tommy Andersson, Marzieh Jönsson, Janna Dejmek, Karim Dib

Publikováno v: International Journal of Cancer. 103:344-351

The collagen-induced phosphorylation of discoidin domain receptor 1 (DDR1) in Wnt-5a-expressing HB2 mammary cells was effectively inhibited by pertussis toxin, but not by cholera toxin or antibodies blocking beta(1) integrins. Moreover, pertussis tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1af461f88299d0959101db8851e81e7
https://doi.org/10.1002/ijc.10752

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