Výsledky vyhledávání - "Karim Debache"

Akademický článek

Vaccines against a Major Cause of Abortion in Cattle, Neospora caninum Infection

Autor: Andrew Hemphill, Karim Debache, Thierry Monney

Publikováno v: Animals, Vol 1, Iss 3, Pp 306-325 (2011)

Neosporosis, caused by the apicomplexan parasite Neospora caninum, represents one of the economically most important causes of abortion in cattle. During pregnancy, the parasite infects the placental tissue and the fetus, which can lead to stillbirth

Externí odkaz: https://doaj.org/article/81459201fe2f42d681f79ce31076adfb

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Growth performance of novel food based on mixture of boiled-dried granulated Tenebrio molitor larvae and date-fruit waste in broiler chicken farming

Autor: Karim Debache

Publikováno v: Asian Journal of Agriculture. 5

Debache K. 2021. Growth performance of novel food based on mixture of boiled-dried granulated Tenebrio molitor larvae and date-fruit waste in broiler chicken farming. Asian J Agric 5: 22-28. The present study was conducted to evaluate the growth perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02c1c6bec6ba04b2df0e022cf58103e9
https://doi.org/10.13057/asianjagric/g050104

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The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures

Autor: Christoph Rampa, Michelle Schorer, Karim Debache, Fabienne Barna, Mohamed A. Ismail, David W. Boykin, Andrew Hemphill, Christian Kropf, Chad E. Stephens

Publikováno v: Kropf, C; Debache, K; Rampa, C; Barna, F; Schorer, M; Stephens, C E; Ismail, M A; Boykin, D W; Hemphill, A (2012). The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures. Parasitology, 139(2), pp. 208-20. London: Cambridge University Press 10.1017/S0031182011001776
Parasitology

SUMMARYThe impact of di-cationic pentamidine-analogues againstToxoplama gondii(Rh- and Me49-background) was investigated. The 72 h-growth assays showed that the arylimidamide DB750 inhibited the proliferation of tachyzoites ofT. gondii RhandT. gondii

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87662428e3cb274d62e57e4ae6c47ea0
http://doc.rero.ch/record/293256/files/S0031182011001776.pdf

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Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination

Autor: Michelle Schorer, Joachim Mueller, Ferial Alaeddine, Andrew Hemphill, Thierry Monney, Norbert Mueller, Karim Debache, Christophe Guionaud

Publikováno v: Frontiers in Bioscience. :23-36

Neospora caninum is an apicomplexan parasite that is capable of infecting, a wide range of tissues. The fact that Neospora represents an important abortion-causing parasite in cattle has transformed neosporosis research from an earlier, rather esoter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dca5e817d4431d0d8f56deb3a8a4747
https://doi.org/10.2741/e593

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Molecular cloning and characterization of NcROP2Fam-1, a member of the ROP2 family of rhoptry proteins in Neospora caninum that is targeted by antibodies neutralizing host cell invasion in vitro

Autor: Karim Debache, Andrew Hemphill, Ferial Alaeddine, Christophe Guionaud

Publikováno v: Parasitology
Alaeddine, Ferial; Hemphill, Andrew; Debache, Karim; Guionaud, Christophe (2013). Molecular cloning and characterization of NcROP2Fam-1, a member of the ROP2 family of rhoptry proteins in Neospora caninum that is targeted by antibodies neutralizing host cell invasion in vitro. Parasitology, 140(8), pp. 1033-1050. Cambridge University Press 10.1017/S0031182013000383

SUMMARYRecent publications demonstrated that a fragment of aNeospora caninumROP2 family member antigen represents a promising vaccine candidate. We here report on the cloning of the cDNA encoding this protein,N. caninumROP2 family member 1 (NcROP2Fam

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Differential effects of intranasal vaccination with recombinant NcPDI in different mouse models ofNeospora caninuminfection

Autor: Karim Debache, Andrew Hemphill

Publikováno v: Parasite immunology

In this study, mice were vaccinated intranasally with recombinant N. caninum protein disulphide isomerase (NcPDI) emulsified in cholera toxin (CT) or cholera toxin subunit B (CTB) from Vibrio cholerae. The effects of vaccination were assessed in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f316e75dbf1fb8c006ec2033bd4a67
https://doi.org/10.1111/pim.12013

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Di-cationic arylimidamides act against Neospora caninum tachyzoites by interference in membrane structure and nucleolar integrity and are active against challenge infection in mice

Autor: Andrew Hemphill, Joachim Müller, Chad E. Stephens, Fabienne Barna, Michelle Schorer, David W. Boykin, Thierry Monney, Karim Debache

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance. 2:109-120

Neospora caninum is considered to be the main cause of bovine abortion in Europe and the USA, leading to considerable financial impact. Losses are caused directly by abortions or indirectly through breeding of calves with impaired viability. Due to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e072c1c7373bea47ed03e13a8d7edf0
https://doi.org/10.1016/j.ijpddr.2012.03.001

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Vaccination with the recombinant chimeric antigen recNcMIC3-1-R induces a non-protective Th2-type immune response in the pregnant mouse model for N. caninum infection

Autor: Andrew Hemphill, Stephen L. Leib, Thierry Monney, Karim Debache, Denis Grandgirard

Publikováno v: Vaccine

The major route of transmission of Neospora caninum in cattle is transplacentally from an infected cow to its progeny. Therefore, a vaccine should be able to prevent both the horizontal transmission from contaminated food or water and the vertical tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87d954b1c65c649727902317266f21a

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Intra-cisternal vaccination induces high-level protection against Neospora caninum infection in mice

Autor: Andrew Hemphill, Karim Debache

Publikováno v: Vaccine

The efficacy of intra-cisternal (IC) immunization in preventing the dissemination of Neospora caninum tachyzoites into the brain was investigated. Mice were vaccinated intracisternally with tachyzoite extract in artificial cerebrospinal fluid (ACSF).

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