Zobrazeno 1 - 10
of 1 221
pro vyhledávání: '"Karim C"'
Autor:
Sarah Bitzer, Mozhgan Dehghan Harati, Karim C. El Kasmi, Daniela Schloesser, Julia Sauer, Heiko Olbrich, Michael Schuler, Florian Gantner, Ralf Heilker
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 149-162 (2023)
Macrophages play a pivotal role in drug discovery due to their key regulatory functions in health and disease. Overcoming the limited availability and donor variability of human monocyte-derived macrophages (MDMs), human induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/682b49992ecd4d21b4b00356826270d2
Autor:
Depeng Zuo, Yiqing Bi, Yonghui Song, Zongxue Xu, Guoqiang Wang, Guangwen Ma, Karim C. Abbaspour, Hong Yang
Publikováno v:
Ecological Indicators, Vol 154, Iss , Pp 110581- (2023)
Non-point source (NPS) pollution has gradually become the main source of water environmental pollution with the rapid economic development during the recent decades, especially for the economically developed Yangtze River Basin of China. Due to rapid
Externí odkaz:
https://doaj.org/article/388c5b816fae454290b4f428229b61ce
Autor:
Depeng Zuo, Guo Chen, Guoqing Wang, Zongxue Xu, Yuna Han, Dingzhi Peng, Bo Pang, Karim C. Abbaspour, Hong Yang
Publikováno v:
Ecological Indicators, Vol 148, Iss , Pp 110145- (2023)
Large-scale implementation of the Grain for Green Project since 1999, which took the Yellow River Basin (YRB) as the core ecological restoration area, has had an important impact on the hydrological processes and ecological environment. Whether such
Externí odkaz:
https://doaj.org/article/5be86f1fbfa3408db3f280b17305a950
Publikováno v:
Hepatology Communications, Vol 7, Iss 3, Pp e0056-e0056 (2023)
Background and Aims:. Parenteral nutrition (PN) in patients with intestinal failure can lead to cholestasis (PNAC). In a PNAC mouse model, farnesoid X receptor (FXR) agonist (GW4064) treatment alleviated IL-1β-dependent cholestatic liver injury. The
Externí odkaz:
https://doaj.org/article/ab816f859480444d84c350d691e3dd1a
Autor:
David Kind, Praveen Baskaran, Fidel Ramirez, Martin Giner, Michael Hayes, Diana Santacruz, Carolin K. Koss, Karim C. el Kasmi, Bhagya Wijayawardena, Coralie Viollet
Publikováno v:
SLAS Technology, Vol 27, Iss 2, Pp 135-142 (2022)
Next-generation sequencing (NGS) has revolutionized genomics, decreasing sequencing costs and allowing researchers to draw correlations between diseases and DNA or RNA changes. Technical advances have enabled the analysis of RNA expression changes be
Externí odkaz:
https://doaj.org/article/446dbb9790314867b3b4a9a1f0e0d35c
Autor:
Colin T Shearn, Aimee L Anderson, Michael W Devereaux, Karim C El Kasmi, David J Orlicky, Ronald J Sokol
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290385 (2023)
BackgroundWe have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transcriptional suppression of bile
Externí odkaz:
https://doaj.org/article/5602d9fb629c4595ba73c8d57a6b453a
Publikováno v:
Journal of Flood Risk Management, Vol 15, Iss 4, Pp n/a-n/a (2022)
Abstract Flood disaster is considered a significant natural hazard due to their devastating effects. The 2019 flood in Northern Iran drastically affected the lives of Indigenous Turkmen pastoralists. This work assesses the vulnerability of the pastor
Externí odkaz:
https://doaj.org/article/f262f32fd6ec485cb6c0732212f9d90e
Publikováno v:
Journal of Water and Climate Change, Vol 12, Iss 5, Pp 2068-2081 (2021)
The impact of climate change on water availability has become a significant cause for concern in the Zayandeh-Roud Reservoir in Iran and similar reservoirs in arid regions. This study investigates the climate change impact on water supply and availab
Externí odkaz:
https://doaj.org/article/529ecfee764640d7a0f5e318d773866e
Autor:
Jonathan R. Baker, Peter S. Fenwick, Carolin K. Koss, Harriet B. Owles, Sarah L. Elkin, Jay Fine, Matthew Thomas, Karim C. El Kasmi, Peter J. Barnes, Louise E. Donnelly
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Current treatments fail to modify the underlying pathophysiology and disease progression of chronic obstructive pulmonary disease (COPD), necessitating alternative therapies. Here, we show that COPD subjects have increased IL-36γ and decreased IL-36
Externí odkaz:
https://doaj.org/article/bfbbfa894e21493c8e3cf8438e35c9e1
Autor:
Madhura Modak, Ann-Kathrin Mattes, Daniela Reiss, Wioletta Skronska-Wasek, Rebecca Langlois, Nicolas Sabarth, Renate Konopitzky, Fidel Ramirez, Katharina Lehr, Tobias Mayr, David Kind, Coralie Viollet, Lee Kim Swee, Jutta Petschenka, Karim C. El Kasmi, Elfriede Noessner, Kerstin Kitt, Stefan Pflanz
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
In many solid cancers, tumor-associated macrophages (TAM) represent the predominant myeloid cell population. Antigen (Ag) cross-presentation leading to tumor Ag–directed cytotoxic CD8+ T cell responses is crucial for antitumor immunity. However, th
Externí odkaz:
https://doaj.org/article/4e405ca8fdb049239e02f1107be9dd50