Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karim Azzag"'
Autor:
Sarah B. Crist, Karim Azzag, James Kiley, Ilsa Coleman, Alessandro Magli, Rita C. R. Perlingeiro
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Pluripotent stem cell (PSC)-based cell therapy is an attractive option for the treatment of multiple human disorders, including muscular dystrophies. While in vitro differentiating PSCs can generate large numbers of human lineage-specific ti
Externí odkaz:
https://doaj.org/article/3ac59d76d3d74db5b598651beb2c7b74
Publikováno v:
Cells, Vol 13, Iss 11, p 972 (2024)
Mutations in the DMD gene cause fatal Duchenne Muscular Dystrophy (DMD). An attractive therapeutic approach is autologous cell transplantation utilizing myogenic progenitors derived from induced pluripotent stem cells (iPSCs). Given that a significan
Externí odkaz:
https://doaj.org/article/8c4239b814e34c778036e237865d9511
Autor:
Karim Azzag, Darko Bosnakovski, Sudheer Tungtur, Peter Salama, Michael Kyba, Rita C. R. Perlingeiro
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant progressive myopathy caused by improper silencing of the DUX4 gene, leading to fibrosis, muscle atrophy, and fatty replacement. Approaches focused on muscle regeneration
Externí odkaz:
https://doaj.org/article/a522fe7c28dc4924a26ab3e5139d2a85
Autor:
Karim Azzag, Heather M. Gransee, Alessandro Magli, Aline M. S. Yamashita, Sudheer Tungtur, Aaron Ahlquist, Wen-Zhi Zhan, Chiemelie Onyebu, Sarah M. Greising, Carlos B. Mantilla, Rita C. R. Perlingeiro
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2503 (2024)
The diaphragm muscle is essential for breathing, and its dysfunctions can be fatal. Many disorders affect the diaphragm, including muscular dystrophies. Despite the clinical relevance of targeting the diaphragm, there have been few studies evaluating
Externí odkaz:
https://doaj.org/article/17c45b6794d542dca7f2ba7badd4c6c9
Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells
Autor:
June Baik, Carolina Ortiz-Cordero, Alessandro Magli, Karim Azzag, Sarah B. Crist, Aline Yamashita, James Kiley, Sridhar Selvaraj, Ricardo Mondragon-Gonzalez, Elizabeth Perrin, John P. Maufort, Jody L. Janecek, Rachael M. Lee, Laura Hocum Stone, Parthasarathy Rangarajan, Sabarinathan Ramachandran, Melanie L. Graham, Rita C. R. Perlingeiro
Publikováno v:
Cells, Vol 12, Iss 8, p 1147 (2023)
Pluripotent stem (PS) cells enable the scalable production of tissue-specific derivatives with therapeutic potential for various clinical applications, including muscular dystrophies. Given the similarity to human counterparts, the non-human primate
Externí odkaz:
https://doaj.org/article/ca90a32d1b4844d29800015a149982ef
Autor:
Karim Azzag, Carolina Ortiz-Cordero, Nelio A. J. Oliveira, Alessandro Magli, Sridhar Selvaraj, Sudheer Tungtur, Weston Upchurch, Paul A. Iaizzo, Qi Long Lu, Rita C. R. Perlingeiro
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Background Defects in α-dystroglycan (DG) glycosylation characterize a group of muscular dystrophies known as dystroglycanopathies. One of the key effectors in the α-DG glycosylation pathway is the glycosyltransferase fukutin-related prote
Externí odkaz:
https://doaj.org/article/09b038388cad461faa07cb5b54f79ca2
Autor:
Neha R. Dhoke, Hyunkee Kim, Sridhar Selvaraj, Karim Azzag, Haowen Zhou, Nelio A.J. Oliveira, Sudheer Tungtur, Carolina Ortiz-Cordero, James Kiley, Qi Long Lu, Anne G. Bang, Rita C.R. Perlingeiro
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109360- (2021)
Summary: Mutations in the fukutin-related protein (FKRP) gene result in a broad spectrum of muscular dystrophy (MD) phenotypes, including the severe Walker-Warburg syndrome (WWS). Here, we develop a gene-editing approach that replaces the entire muta
Externí odkaz:
https://doaj.org/article/6c28b824295349c796db8b9112b5789f
Autor:
Ricardo Mondragon-Gonzalez, Karim Azzag, Sridhar Selvaraj, Ami Yamamoto, Rita C.R. Perlingeiro
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 553-562 (2019)
Background: Stem cell transplantation represents a potential therapeutic option for muscular dystrophies (MD). However, to date, most reports have utilized mouse models for recessive types of MD. Here we performed studies to determine whether myotoni
Externí odkaz:
https://doaj.org/article/3d1ddf5f0da9456b9e9fc0621d7320a3
Autor:
Karim Azzag, Yoann Chelin, François Rousset, Emilie Le Goff, Camille Martinand-Mari, Anne-Marie Martinez, Bernard Maurin, Martine Daujat-Chavanieu, Nelly Godefroy, Julien Averseng, Paul Mangeat, Stephen Baghdiguian
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126341 (2015)
Previous studies have addressed why and how mono-stratified epithelia adopt a polygonal topology. One major additional, and yet unanswered question is how the frequency of different cell shapes is achieved and whether the same distribution applies be
Externí odkaz:
https://doaj.org/article/b2114752291e43f1b76fb99f4eeae7c9
Publikováno v:
UNIVERSITY NEWS. NORTH-CAUCASIAN REGION. NATURAL SCIENCES SERIES. :17-23
Despite the fact that the representation of epithelium as a tessellation of a plane into polygons has existed for several centuries, it is still not clear exactly how cellular geometry affects the transformation from plane epithelial monolayers into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea68f51b011cfc735aa7aee778fb2a70
https://doi.org/10.18522/1026-2237-2023-1-17-23
https://doi.org/10.18522/1026-2237-2023-1-17-23