Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Karim, Hamesch"'
Autor:
Maike R. Pollmanns, Qendrim Pajaziti, Philipp Hohlstein, Jule K. Adams, Samira Abu Jhaisha, Elena Kabak, Karim Hamesch, Sophie H. A. Nusser, Ralf Weiskirchen, Theresa H. Wirtz, Alexander Koch
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2173 (2024)
Background: Adiponectin, an adipokine with anti-inflammatory properties, has been implicated in various liver diseases. This study aimed to elucidate the prognostic value of serum adiponectin levels in critically ill patients with liver disease. Meth
Externí odkaz:
https://doaj.org/article/048515c788434229b05c39c9ac573f6d
Autor:
Firas Khader, Jakob Nikolas Kather, Gustav Müller-Franzes, Tianci Wang, Tianyu Han, Soroosh Tayebi Arasteh, Karim Hamesch, Keno Bressem, Christoph Haarburger, Johannes Stegmaier, Christiane Kuhl, Sven Nebelung, Daniel Truhn
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract When clinicians assess the prognosis of patients in intensive care, they take imaging and non-imaging data into account. In contrast, many traditional machine learning models rely on only one of these modalities, limiting their potential in
Externí odkaz:
https://doaj.org/article/137023c7cd0440f98a47882e0dac9407
Autor:
Philipp Hohlstein, Can Salvarcioglu, Maike R. Pollmanns, Jule K. Adams, Samira Abu Jhaisha, Elena Kabak, Albrecht Eisert, Karim Hamesch, Ralf Weiskirchen, Alexander Koch, Theresa H. Wirtz
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1170 (2024)
Differentiation between acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) can be challenging in patients with de novo liver disease but is important to indicate the referral to a transplant center and urgency of organ allocation. Le
Externí odkaz:
https://doaj.org/article/d0e07589ebb64b8a8ef6834367d396bb
Autor:
Samira Abu Jhaisha, Philipp Hohlstein, Eray Yagmur, Vera Köller, Maike R. Pollmanns, Jule K. Adams, Theresa H. Wirtz, Jonathan F. Brozat, Lukas Bündgens, Karim Hamesch, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch
Publikováno v:
Diagnostics, Vol 14, Iss 4, p 370 (2024)
Semaphorin 4D (Sema4D), also known as CD100, is a multifunctional transmembrane protein with immunoregulatory functions. Upon the activation of immune cells, soluble Semaphorin 4D (sSema4D) is proteolytically cleaved from the membrane by metalloprote
Externí odkaz:
https://doaj.org/article/554721f4a4dc4cd281bbfb12761d0fc6
Autor:
Sophia M. Schmitz, Sebastian Storms, Alexander Koch, Christine Stier, Andreas Kroh, Karl P. Rheinwalt, Sandra Schipper, Karim Hamesch, Tom F. Ulmer, Ulf P. Neumann, Patrick H. Alizai
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1595 (2023)
(1) Background: Metabolically healthy obesity (MHO) is a concept that applies to obese patients without any elements of metabolic syndrome (metS). In turn, metabolically unhealthy obesity (MUO) defines the presence of elements of metS in obese patien
Externí odkaz:
https://doaj.org/article/88e95fbdcf224a3d94a62deb870a5c8e
Autor:
Nurdan Guldiken, Josepmaria Argemi, Berivan Gurbuz, Stephen R. Atkinson, Martin Oliverius, Petr Fila, Karim Hamesch, Tony Bruns, Joaquín Cabezas, Juan J. Lozano, Jelena Mann, Sheng Cao, Philippe Mathurin, Vijay H. Shah, Christian Trautwein, Mark R. Thursz, Ramon Bataller, Pavel Strnad
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Serum transferrin levels represent an independent predictor of mortality in patients with liver failure. Hepatocyte nuclear factor 4 alpha (HNF4α) is a master regulator of hepatocyte functions. The aim of this study was to explor
Externí odkaz:
https://doaj.org/article/1275100d75664e55abccc68f1de7fd24
Autor:
Karim Hamesch, Nurdan Guldiken, Mahmoud Aly, Norbert Hüser, Daniel Hartmann, Pierre Rufat, Marianne Ziol, Katharina Remih, Georg Lurje, Bernhard Scheiner, Christian Trautwein, Mattias Mandorfer, Thomas Reiberger, Sebastian Mueller, Tony Bruns, Pierre Nahon, Pavel Strnad
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background Keratins (Ks) represent tissue-specific proteins. K18 is produced in hepatocytes while K19, the most widely used ductular reaction (DR) marker, is found in cholangiocytes and hepatic progenitor cells. K18-based serum fragments are
Externí odkaz:
https://doaj.org/article/fbbf0c3b59154001abc9f9ec40dff6ce
Autor:
Philipp Hohlstein, Jonathan F. Brozat, Julia Schuler, Samira Abu Jhaisha, Maike R. Pollmanns, Lukas Bündgens, Theresa H. Wirtz, Eray Yagmur, Karim Hamesch, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 313 (2023)
Sepsis is a major health burden with insufficiently understood mechanisms of inflammation and immune paralysis, leading to a life-threatening critical illness. The secreted frizzled related protein 5 (SFRP5) acts as an anti-inflammatory adipokine by
Externí odkaz:
https://doaj.org/article/756f0be269ba487f97a8d66ec473c217
Autor:
Tobias Puengel, Beate Weber, Theresa H. Wirtz, Lukas Buendgens, Sven H. Loosen, Lukas Geisler, Burcin Özdirik, Karim Hamesch, Samira Abu Jhaisha, Jonathan F. Brozat, Philipp Hohlstein, Albrecht Eisert, Eray Yagmur, Christian Trautwein, Frank Tacke, Alexander Koch
Publikováno v:
Diagnostics, Vol 12, Iss 1, p 62 (2021)
Soluble receptor activator of nuclear factor κ B ligand (sRANKL) is a member of the tumor necrosis factor receptor superfamily, and therefore, involved in various inflammatory processes. The role of sRANKL in the course of bone remodeling via activa
Externí odkaz:
https://doaj.org/article/540bb2eab9084ad59a084d1375bdcb40
Autor:
Berkan Kurt, Lukas Buendgens, Theresa H. Wirtz, Sven H. Loosen, Maximilian Schulze-Hagen, Daniel Truhn, Jonathan F. Brozat, Samira Abu Jhaisha, Philipp Hohlstein, Ger Koek, Ralf Weiskirchen, Christian Trautwein, Frank Tacke, Karim Hamesch, Alexander Koch
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1210 (2021)
Perilipin 2 (PLIN2) is a lipid droplet protein with various metabolic functions. However, studies investigating PLIN2 in the context of inflammation, especially in systemic and acute inflammation, are lacking. Hence, we assessed the relevance of seru
Externí odkaz:
https://doaj.org/article/091fdb44a6ae4d3c9d726cf89cc64011